RAD51 nucleoprotein filament on abasic single-stranded DNA
Hanthi YW, Ramirez-Otero MA, Appleby R, De Antoni A, Joudeh L, Sannino V, Waked S, Ardizzoia A, Barra V, Fachinetti D, Pellegrini L, Costanzo V
Mol Cell (2024) 84 pp. 3026-3043.e11 [ Pubmed: 39178838 DOI: doi:10.1016/j.molcel.2024.07.004 ]
- Calcium ion (40 Da, Ligand)
- Rad51 nucleoprotein filament (Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Dna (5'-d(p*gp*gp*(3dr)p*ap*tp*(3dr)p*cp*ap*(3dr)p*tp*gp*(3dr)p*tp*ap*(3dr)p*ap*cp*(3dr)p*tp*gp*(3dr)p*gp*c)-3') (6 kDa, DNA from Homo sapiens)
- Dna repair protein rad51 homolog 1 (37 kDa, Protein from Homo sapiens)
RAD51 nucleoprotein filament on double-stranded abasic DNA
Hanthi YW, Ramirez-Otero MA, Appleby R, De Antoni A, Joudeh L, Sannino V, Waked S, Ardizzoia A, Barra V, Fachinetti D, Pellegrini L, Costanzo V
Mol Cell (2024) 84 pp. 3026-3043.e11 [ Pubmed: 39178838 DOI: doi:10.1016/j.molcel.2024.07.004 ]
- Rad51 nucleoprotein filament on double-stranded abasic dna (Complex)
- Calcium ion (40 Da, Ligand)
- Dna (5'-d(p*tp*gp*(3dr)p*tp*gp*(3dr)p*tp*gp*(3dr)p*tp*gp*(3dr)p*tp*gp*(3dr)p*tp*gp*(3dr)p*tp*gp*(3dr)p*tp*g)-3') (6 kDa, DNA from Homo sapiens)
- Dna repair protein (Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Dna (Complex from Homo sapiens)
- Dna (5'-d(p*cp*ap*cp*cp*ap*cp*cp*ap*cp*cp*ap*cp*cp*ap*cp*cp*ap*cp*cp*ap*cp*cp*a)-3') (6 kDa, DNA from Homo sapiens)
- Dna repair protein rad51 homolog 1 (37 kDa, Protein from Homo sapiens)
RAD51 filament on ssDNA bound by the BRCA2 c-terminus
Resolution: 2.61 Å
EM Method: Helical reconstruction
Fitted PDBs: 8pbc
Q-score: 0.551
Appleby R, Joudeh L, Cobbett K, Pellegrini L
Nat Commun (2023) 14 pp. 7003-7003 [ DOI: doi:10.1038/s41467-023-42830-1 Pubmed: 37919288 ]
- Calcium ion (40 Da, Ligand)
- Breast cancer type 2 susceptibility protein (Complex from Homo sapiens)
- Dna repair protein rad51 homolog 1 (Complex from Homo sapiens)
- Dna (30-mer) (Complex from synthetic construct)
- Dna (30-mer) (9 kDa, DNA from synthetic construct)
- Breast cancer type 2 susceptibility protein (5 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Rad51 filament formed on ssdna and bound with a peptide corresponding to the brca2 c-terminus (Complex)
- Dna repair protein rad51 homolog 1 (37 kDa, Protein from Homo sapiens)
RAD51 filament on dsDNA bound by the BRCA2 c-terminus
Resolution: 2.83 Å
EM Method: Helical reconstruction
Fitted PDBs: 8pbd
Q-score: 0.535
Appleby R, Joudeh L, Cobbett K, Pellegrini L
Nat Commun (2023) 14 pp. 7003-7003 [ DOI: doi:10.1038/s41467-023-42830-1 Pubmed: 37919288 ]
- Dna strand 1 (8 kDa, DNA from synthetic construct)
- Calcium ion (40 Da, Ligand)
- Breast cancer type 2 susceptibility protein (Complex from Homo sapiens)
- Dna repair protein rad51 homolog 1 (Complex from Homo sapiens)
- Rad51 filament formed on dsdna and bound with a peptide corresponding to the brca2 c-terminus (Complex)
- Dna strand 2 (7 kDa, DNA from synthetic construct)
- Dna strand 1 and 2 (Complex from synthetic construct)
- Breast cancer type 2 susceptibility protein (5 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Dna repair protein rad51 homolog 1 (37 kDa, Protein from Homo sapiens)
CryoEM structure of the RAD51_ADP filament
Resolution: 3.14 Å
EM Method: Helical reconstruction
Fitted PDBs: 8gyk
Q-score: 0.426
Luo SC, Yeh MC, Lien YH, Yeh HY, Siao HL, Tu IP, Chi P, Ho MC
Nat Commun (2023) 14 pp. 4993-4993 [ Pubmed: 37591853 DOI: doi:10.1038/s41467-023-40672-5 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Hrad51-adp filament intermediate (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Dna repair protein rad51 homolog 1 (37 kDa, Protein from Homo sapiens)
CryoEM structure of the post-synaptic RAD51 nucleoprotein filament in the presence of ATP and Ca2+
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8br2
Q-score: 0.573
Appleby R, Bollschweiler D, Chirgadze DY, Joudeh L, Pellegrini L
iScience (2023) 26 pp. 106689-106689 [ DOI: doi:10.1016/j.isci.2023.106689 Pubmed: 37216117 ]
- Dna (5'-d(p*gp*cp*gp*ap*gp*cp*tp*cp*gp*ap*tp*gp*cp*ap*cp*cp*tp*cp*cp*a)-3') (6 kDa, DNA from Homo sapiens)
- Water (18 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Post-synaptic rad51 nucleoprotein filament in the presence of atp and ca2+ (Complex from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Dna (5'-d(p*tp*gp*gp*ap*gp*gp*tp*gp*cp*ap*tp*cp*gp*ap*gp*cp*tp*cp*gp*c)-3') (6 kDa, DNA from Homo sapiens)
- Dna repair protein rad51 homolog 1 (37 kDa, Protein from Homo sapiens)
CryoEM structure of the RAD51 nucleoprotein filament in the presence of ADP and Ca2+
Resolution: 3.6 Å
EM Method: Helical reconstruction
Fitted PDBs: 8bsc
Q-score: 0.462
Appleby R, Bollschweiler D, Chirgadze DY, Joudeh L, Pellegrini L
iScience (2023) 26 pp. 106689-106689 [ DOI: doi:10.1016/j.isci.2023.106689 Pubmed: 37216117 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Dna repair protein rad51 homolog 1 (37 kDa, Protein from Homo sapiens)
- Filament of human rad51 bound to adp and ca2+ (Complex from Homo sapiens)
human RAD51 presynaptic complex
Resolution: 2.97 Å
EM Method: Helical reconstruction
Fitted PDBs: 7ejc
Q-score: 0.554
Xu J, Zhao L, Peng S, Chu H, Liang R, Tian M, Connell PP, Li G, Chen C, Wang HW
Nucleic Acids Res (2021) 49 pp. 13135-13149 [ DOI: doi:10.1093/nar/gkab1141 Pubmed: 34871438 ]
- 4-bromanyl-n-(4-bromophenyl)-3-[(phenylmethyl)sulfamoyl]benzamide (524 Da, Ligand)
- Human rad51 (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Dna repair protein rad51 homolog 1 (37 kDa, Protein from Homo sapiens)
- Dna (Complex from Homo sapiens)
- Dna (5'-d(p*tp*tp*tp*tp*tp*tp*tp*tp*t)-3') (2 kDa, DNA from Homo sapiens)
- Human rad51 presynaptic complex (Complex)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
human RAD51 post-synaptic complex
Resolution: 3.98 Å
EM Method: Helical reconstruction
Fitted PDBs: 7eje
Q-score: 0.382
Xu J, Zhao L, Peng S, Chu H, Liang R, Tian M, Connell PP, Li G, Chen C, Wang HW
Nucleic Acids Res (2021) 49 pp. 13135-13149 [ DOI: doi:10.1093/nar/gkab1141 Pubmed: 34871438 ]
- Dna (Complex)
- Dna (5'-d(p*ap*ap*ap*ap*ap*ap*ap*ap*a)-3') (2 kDa, DNA from Homo sapiens)
- Human rad51 post-synaptic complex (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Dna (5'-d(p*tp*tp*tp*tp*tp*tp*tp*tp*t)-3') (2 kDa, DNA from Homo sapiens)
- Dna repair protein rad51 homolog 1 (37 kDa, Protein from Homo sapiens)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Human rad51 (Complex)
Human RAD51 post-synaptic complexes mutant (V273P, D274G)
Resolution: 3.43 Å
EM Method: Helical reconstruction
Fitted PDBs: 7c9a
Q-score: 0.51
Luo SC, Yeh HY, Lan WH, Wu YM, Yang CH, Chang HY, Su GC, Lee CY, Wu WJ, Li HW, Ho MC, Chi P, Tsai MD
Nat Commun (2021) 12 pp. 115-115 [ DOI: doi:10.1038/s41467-020-20258-1 Pubmed: 33446654 ]
- Calcium ion (40 Da, Ligand)
- Rad51-dsdna filament (v273p d274g mutant) (Complex from Homo sapiens)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Dna (5'-d(p*tp*tp*tp*tp*tp*tp*tp*tp*t)-3') (2 kDa, DNA from Homo sapiens)
- Dna (5'-d(p*ap*ap*ap*ap*ap*ap*ap*ap*a)-3') (2 kDa, DNA from Homo sapiens)
- Dna repair protein rad51 homolog 1 (36 kDa, Protein from Homo sapiens)