Human OCCM DNA licensing intermediate
Resolution: 6.68 Å
EM Method: Single-particle
Fitted PDBs: 8rwv
Q-score: 0.186
Wells JN, Edwardes LV, Leber V, Allyjaun S, Peach M, Tomkins J, Kefala-Stavridi A, Faull SV, Aramayo R, Pestana CM, Ranjha L, Speck C
Nat Commun (2025) 16 pp. 478-478 [ Pubmed: 39779677 DOI: doi:10.1038/s41467-024-55772-z ]
- Dna replication factor cdt1 (46 kDa, Protein from Homo sapiens)
- Isoform 2 of dna replication licensing factor mcm3 (96 kDa, Protein from Homo sapiens)
- Origin recognition complex subunit 1 (108 kDa, Protein from Homo sapiens)
- Origin recognition complex subunit 5 (50 kDa, Protein from Homo sapiens)
- Origin recognition complex subunit 4 (50 kDa, Protein from Homo sapiens)
- Dna (11 kDa, DNA from Homo sapiens)
- Dna replication licensing factor mcm2 (106 kDa, Protein from Homo sapiens)
- Origin recognition complex subunit 2 (66 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm7 (81 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm4 (99 kDa, Protein from Homo sapiens)
- Hoccm (1 MDa, Complex from Homo sapiens)
- Isoform 2 of origin recognition complex subunit 3 (82 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm6 (93 kDa, Protein from Homo sapiens)
- Cell division control protein 6 homolog (62 kDa, Protein from Homo sapiens)
- Dna (12 kDa, DNA from Homo sapiens)
Cryo-EM structure of a human MCM2-7 single hexamer on dsDNA
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8w0e
Q-score: 0.445
Yang R, Hunker O, Wise M, Bleichert F
Nature (2024) 636 pp. 488-498 [ Pubmed: 39604729 DOI: doi:10.1038/s41586-024-08237-8 ]
- Dna replication licensing factor mcm5 (82 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm4 (96 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Dna replication licensing factor mcm6 (93 kDa, Protein from Homo sapiens)
- Dna (25-mer) (7 kDa, DNA from Saccharomyces cerevisiae)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- In vitro loaded, human mcm2-7 single hexamer on dsdna (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Dna replication licensing factor mcm7 (81 kDa, Protein from Homo sapiens)
- Dna (25-mer) (7 kDa, DNA from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm2 (102 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm3 (91 kDa, Protein from Homo sapiens)
Cryo-EM structure of a human MCM2-7 double hexamer on dsDNA
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8w0f
Q-score: 0.501
Yang R, Hunker O, Wise M, Bleichert F
Nature (2024) 636 pp. 488-498 [ Pubmed: 39604729 DOI: doi:10.1038/s41586-024-08237-8 ]
- Dna replication licensing factor mcm5 (82 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm4 (96 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- In vitro loaded, human mcm2-7 double hexamer on dsdna (Complex from Homo sapiens)
- Dna (47-mer) (14 kDa, DNA from Saccharomyces cerevisiae)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Dna replication licensing factor mcm6 (93 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Dna replication licensing factor mcm7 (81 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm2 (102 kDa, Protein from Homo sapiens)
- Dna (47-mer) (14 kDa, DNA from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm3 (91 kDa, Protein from Homo sapiens)
Cryo-EM structure of a human MCM2-7 dimer
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8w0g
Q-score: 0.268
Yang R, Hunker O, Wise M, Bleichert F
Nature (2024) 636 pp. 488-498 [ Pubmed: 39604729 DOI: doi:10.1038/s41586-024-08237-8 ]
- Human mcm2-7 dimer (Complex from Homo sapiens)
- Dna replication licensing factor mcm5 (82 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm4 (96 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Dna replication licensing factor mcm6 (93 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Dna replication licensing factor mcm7 (81 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm2 (102 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm3 (91 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human MCM2-7 heterohexamer
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8w0i
Q-score: 0.367
Yang R, Hunker O, Wise M, Bleichert F
Nature (2024) 636 pp. 488-498 [ Pubmed: 39604729 DOI: doi:10.1038/s41586-024-08237-8 ]
- Dna replication licensing factor mcm5 (82 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm4 (96 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Dna replication licensing factor mcm6 (93 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Dna replication licensing factor mcm7 (81 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm2 (102 kDa, Protein from Homo sapiens)
- Human mcm2-7 heterohexamer (Complex from Homo sapiens)
- Dna replication licensing factor mcm3 (91 kDa, Protein from Homo sapiens)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 9caq
Q-score: 0.396
Yang R, Hunker O, Wise M, Bleichert F
Nature (2024) 636 pp. 488-498 [ Pubmed: 39604729 DOI: doi:10.1038/s41586-024-08237-8 ]
- Dna replication licensing factor mcm3 (91 kDa, Protein from Homo sapiens)
- Dna (44-mer) (13 kDa, DNA from Saccharomyces cerevisiae)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Dna replication licensing factor mcm5 (82 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm6 (93 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Dna replication licensing factor mcm4 (96 kDa, Protein from Homo sapiens)
- Dna (44-mer) (13 kDa, DNA from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm2 (102 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm7 (81 kDa, Protein from Homo sapiens)
- In vitro loaded, human mcm2-7 double hexamer on dsdna (formed by dimerization of independently loaded mcm2-7 single hexamers) (Complex from Homo sapiens)
X. laevis CMG dimer bound to dimeric DONSON - without ATPase
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 8q6o
Q-score: 0.471
Cvetkovic MA, Passaretti P, Butryn A, Reynolds-Winczura A, Kingsley G, Skagia A, Fernandez-Cuesta C, Poovathumkadavil D, George R, Chauhan AS, Jhujh SS, Stewart GS, Gambus A, Costa A
Mol Cell (2023) 83 pp. 4017- [ Pubmed: 37820732 DOI: doi:10.1016/j.molcel.2023.09.029 ]
- Dna replication licensing factor mcm5-a (82 kDa, Protein from Xenopus laevis)
- Dna replication complex gins protein psf3 (23 kDa, Protein from Xenopus laevis)
- Maternal dna replication licensing factor mcm6 (92 kDa, Protein from Xenopus laevis)
- X. laevis cmg dimer bound to dimeric donson (1 MDa, Complex from Xenopus laevis)
- Cell division control protein 45 homolog (65 kDa, Protein from Xenopus laevis)
- Dna replication licensing factor mcm7-b (81 kDa, Protein from Xenopus laevis)
- Protein downstream neighbor of son homolog (63 kDa, Protein from Xenopus laevis)
- Zinc ion (65 Da, Ligand)
- Dna replication licensing factor mcm2 (100 kDa, Protein from Xenopus laevis)
- Dna replication complex gins protein psf1 (23 kDa, Protein from Xenopus laevis)
- Dna replication complex gins protein psf2 (21 kDa, Protein from Xenopus laevis)
- Maternal dna replication licensing factor mcm3 (90 kDa, Protein from Xenopus laevis)
- Dna replication complex gins protein sld5 (25 kDa, Protein from Xenopus laevis)
- Dna replication licensing factor mcm4-b (97 kDa, Protein from Xenopus laevis)
X. laevis CMG dimer bound to dimeric DONSON - MCM ATPase
Resolution: 3.53 Å
EM Method: Single-particle
Fitted PDBs: 8q6p
Q-score: 0.369
Cvetkovic MA, Passaretti P, Butryn A, Reynolds-Winczura A, Kingsley G, Skagia A, Fernandez-Cuesta C, Poovathumkadavil D, George R, Chauhan AS, Jhujh SS, Stewart GS, Gambus A, Costa A
Mol Cell (2023) 83 pp. 4017- [ Pubmed: 37820732 DOI: doi:10.1016/j.molcel.2023.09.029 ]
- Dna replication licensing factor mcm5-a (82 kDa, Protein from Xenopus laevis)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Maternal dna replication licensing factor mcm6 (92 kDa, Protein from Xenopus laevis)
- X. laevis cmg dimer bound to dimeric donson (1 MDa, Complex from Xenopus laevis)
- Protein downstream neighbor of son homolog (63 kDa, Protein from Xenopus laevis)
- Dna replication licensing factor mcm7-b (81 kDa, Protein from Xenopus laevis)
- Dna replication licensing factor mcm2 (100 kDa, Protein from Xenopus laevis)
- Maternal dna replication licensing factor mcm3 (90 kDa, Protein from Xenopus laevis)
- Dna replication licensing factor mcm4-b (97 kDa, Protein from Xenopus laevis)
Single CMG purified from replicating Xenopus egg extracts
Cvetkovic MA, Passaretti P, Butryn A, Reynolds-Winczura A, Kingsley G, Skagia A, Fernandez-Cuesta C, Poovathumkadavil D, George R, Chauhan AS, Jhujh SS, Stewart GS, Gambus A, Costa A
Mol Cell (2023) 83 pp. 4017-4031.e9 [ Pubmed: 37820732 DOI: doi:10.1016/j.molcel.2023.09.029 ]
- Dna replication complex gins protein psf2 - xenopus laevis (Protein from Xenopus laevis)
- Dna replication licensing factor mcm3 - xenopus laevis (Protein from Xenopus laevis)
- Dna replication complex gins protein sld5 - xenopus laevis (Protein from Xenopus laevis)
- Dna replication licensing factor mcm5 - xenopus laevis (Protein from Xenopus laevis)
- Dna replication licensing factor mcm2 - xenopus laevis (Protein from Xenopus laevis)
- Dna replication complex gins protein psf1 - xenopus laevis (Protein from Xenopus laevis)
- Dna replication complex gins protein psf3 - xenopus laevis (Protein from Xenopus laevis)
- Single cmg purified from replicating xenopus egg extracts (700 kDa, Complex from Xenopus laevis)
- Cell division control protein 45 - xenopus laevis (Protein from Xenopus laevis)
- Dna replication licensing factor mcm7 - xenopus laevis (Protein from Xenopus laevis)
- Dna replication licensing factor mcm6 - xenopus laevis (Protein from Xenopus laevis)
- Dna replication licensing factor mcm4 - xenopus laevis (Protein from Xenopus laevis)
Resolution: 3.75 Å
EM Method: Single-particle
Fitted PDBs: 8ouw
Q-score: 0.329
Xia Y, Sonneville R, Jenkyn-Bedford M, Ji L, Alabert C, Hong Y, Yeeles JTP, Labib KPM
Science (2023) 381 pp. eadi4932-eadi4932 [ DOI: doi:10.1126/science.adi4932 Pubmed: 37590372 ]
- Dna replication licensing factor mcm-5 (85 kDa, Protein from Caenorhabditis elegans)
- Dna replication complex gins protein psf3 (21 kDa, Protein from Caenorhabditis elegans)
- Cell division control protein 45 homolog (66 kDa, Protein from Caenorhabditis elegans)
- Dna replication licensing factor mcm2 (99 kDa, Protein from Caenorhabditis elegans)
- Dna replication licensing factor mcm-4 (91 kDa, Protein from Caenorhabditis elegans)
- Dna replication licensing factor mcm7 (81 kDa, Protein from Caenorhabditis elegans)
- Complex of cmg helicase bound to tim-1/tipn-1 and homodimeric dnsn-1 on fork dna (caenorhabditis elegans) (Complex from Caenorhabditis elegans)
- Magnesium ion (24 Da, Ligand)
- Dna leading strand template (26 kDa, DNA from Saccharomyces cerevisiae)
- Downstream neighbor of son homolog (66 kDa, Protein from Caenorhabditis elegans)
- Probable dna replication complex gins protein psf2 (20 kDa, Protein from Caenorhabditis elegans)
- Dna replication licensing factor mcm3 (90 kDa, Protein from Caenorhabditis elegans)
- Protein tipin homolog (27 kDa, Protein from Caenorhabditis elegans)
- Zinc ion (65 Da, Ligand)
- Dna replication licensing factor mcm-6 (91 kDa, Protein from Caenorhabditis elegans)
- Probable dna replication complex gins protein psf1 (23 kDa, Protein from Caenorhabditis elegans)
- Dna replication complex gins protein sld5 (25 kDa, Protein from Caenorhabditis elegans)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Dna lagging strand template (18 kDa, DNA from Saccharomyces cerevisiae)
- Protein timeless homolog (157 kDa, Protein from Caenorhabditis elegans)