Human OCCM DNA licensing intermediate
Resolution: 6.68 Å
EM Method: Single-particle
Fitted PDBs: 8rwv
Q-score: 0.186
Wells JN, Edwardes LV, Leber V, Allyjaun S, Peach M, Tomkins J, Kefala-Stavridi A, Faull SV, Aramayo R, Pestana CM, Ranjha L, Speck C
Nat Commun (2025) 16 pp. 478-478 [ Pubmed: 39779677 DOI: doi:10.1038/s41467-024-55772-z ]
- Dna replication factor cdt1 (46 kDa, Protein from Homo sapiens)
- Isoform 2 of dna replication licensing factor mcm3 (96 kDa, Protein from Homo sapiens)
- Origin recognition complex subunit 1 (108 kDa, Protein from Homo sapiens)
- Origin recognition complex subunit 5 (50 kDa, Protein from Homo sapiens)
- Origin recognition complex subunit 4 (50 kDa, Protein from Homo sapiens)
- Dna (11 kDa, DNA from Homo sapiens)
- Dna replication licensing factor mcm2 (106 kDa, Protein from Homo sapiens)
- Origin recognition complex subunit 2 (66 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm7 (81 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm4 (99 kDa, Protein from Homo sapiens)
- Hoccm (1 MDa, Complex from Homo sapiens)
- Isoform 2 of origin recognition complex subunit 3 (82 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm6 (93 kDa, Protein from Homo sapiens)
- Cell division control protein 6 homolog (62 kDa, Protein from Homo sapiens)
- Dna (12 kDa, DNA from Homo sapiens)
Resolution: 6.1 Å
EM Method: Single-particle
Fitted PDBs: 9bcx
Q-score: 0.133
Faull SV, Barbon M, Mossler A, Yuan Z, Bai L, Reuter LM, Riera A, Winkler C, Magdalou I, Peach M, Li H, Speck C
Nat Commun (2025) 16 pp. 14-14 [ Pubmed: 39747125 DOI: doi:10.1038/s41467-024-55479-1 ]
- Origin recognition complex subunit 1 (104 kDa, Protein from Saccharomyces cerevisiae)
- Dna (39-mer) (12 kDa, DNA from synthetic construct)
- Dna replication licensing factor mcm6 (113 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm7 (95 kDa, Protein from Saccharomyces cerevisiae)
- Cell division control protein 6 (58 kDa, Protein from Saccharomyces cerevisiae)
- Magnesium ion (24 Da, Ligand)
- Origin recognition complex subunit 5 (55 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm4 (105 kDa, Protein from Saccharomyces cerevisiae)
- Dna (39-mer) (11 kDa, DNA from synthetic construct)
- Dna replication licensing factor mcm2 (98 kDa, Protein from Saccharomyces cerevisiae)
- Origin recognition complex subunit 3 (72 kDa, Protein from Saccharomyces cerevisiae)
- Origin recognition complex subunit 2 (71 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm3 (107 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm5 (86 kDa, Protein from Saccharomyces cerevisiae)
- Origin recognition complex subunit 6 (50 kDa, Protein from Saccharomyces cerevisiae)
- Tah11 isoform 1 (68 kDa, Protein from Saccharomyces cerevisiae)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Orc-cdc6-mcm2-7-dsdna (Complex from Saccharomyces cerevisiae)
- Origin recognition complex subunit 4 (60 kDa, Protein from Saccharomyces cerevisiae)
X. laevis CMG dimer bound to dimeric DONSON - without ATPase
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 8q6o
Q-score: 0.471
Cvetkovic MA, Passaretti P, Butryn A, Reynolds-Winczura A, Kingsley G, Skagia A, Fernandez-Cuesta C, Poovathumkadavil D, George R, Chauhan AS, Jhujh SS, Stewart GS, Gambus A, Costa A
Mol Cell (2023) 83 pp. 4017- [ Pubmed: 37820732 DOI: doi:10.1016/j.molcel.2023.09.029 ]
- Dna replication licensing factor mcm5-a (82 kDa, Protein from Xenopus laevis)
- Dna replication complex gins protein psf3 (23 kDa, Protein from Xenopus laevis)
- Maternal dna replication licensing factor mcm6 (92 kDa, Protein from Xenopus laevis)
- X. laevis cmg dimer bound to dimeric donson (1 MDa, Complex from Xenopus laevis)
- Cell division control protein 45 homolog (65 kDa, Protein from Xenopus laevis)
- Dna replication licensing factor mcm7-b (81 kDa, Protein from Xenopus laevis)
- Protein downstream neighbor of son homolog (63 kDa, Protein from Xenopus laevis)
- Zinc ion (65 Da, Ligand)
- Dna replication licensing factor mcm2 (100 kDa, Protein from Xenopus laevis)
- Dna replication complex gins protein psf1 (23 kDa, Protein from Xenopus laevis)
- Dna replication complex gins protein psf2 (21 kDa, Protein from Xenopus laevis)
- Maternal dna replication licensing factor mcm3 (90 kDa, Protein from Xenopus laevis)
- Dna replication complex gins protein sld5 (25 kDa, Protein from Xenopus laevis)
- Dna replication licensing factor mcm4-b (97 kDa, Protein from Xenopus laevis)
X. laevis CMG dimer bound to dimeric DONSON - MCM ATPase
Resolution: 3.53 Å
EM Method: Single-particle
Fitted PDBs: 8q6p
Q-score: 0.369
Cvetkovic MA, Passaretti P, Butryn A, Reynolds-Winczura A, Kingsley G, Skagia A, Fernandez-Cuesta C, Poovathumkadavil D, George R, Chauhan AS, Jhujh SS, Stewart GS, Gambus A, Costa A
Mol Cell (2023) 83 pp. 4017- [ Pubmed: 37820732 DOI: doi:10.1016/j.molcel.2023.09.029 ]
- Dna replication licensing factor mcm5-a (82 kDa, Protein from Xenopus laevis)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Maternal dna replication licensing factor mcm6 (92 kDa, Protein from Xenopus laevis)
- X. laevis cmg dimer bound to dimeric donson (1 MDa, Complex from Xenopus laevis)
- Protein downstream neighbor of son homolog (63 kDa, Protein from Xenopus laevis)
- Dna replication licensing factor mcm7-b (81 kDa, Protein from Xenopus laevis)
- Dna replication licensing factor mcm2 (100 kDa, Protein from Xenopus laevis)
- Maternal dna replication licensing factor mcm3 (90 kDa, Protein from Xenopus laevis)
- Dna replication licensing factor mcm4-b (97 kDa, Protein from Xenopus laevis)
Single CMG purified from replicating Xenopus egg extracts
Cvetkovic MA, Passaretti P, Butryn A, Reynolds-Winczura A, Kingsley G, Skagia A, Fernandez-Cuesta C, Poovathumkadavil D, George R, Chauhan AS, Jhujh SS, Stewart GS, Gambus A, Costa A
Mol Cell (2023) 83 pp. 4017-4031.e9 [ Pubmed: 37820732 DOI: doi:10.1016/j.molcel.2023.09.029 ]
- Dna replication complex gins protein psf2 - xenopus laevis (Protein from Xenopus laevis)
- Dna replication licensing factor mcm3 - xenopus laevis (Protein from Xenopus laevis)
- Dna replication complex gins protein sld5 - xenopus laevis (Protein from Xenopus laevis)
- Dna replication licensing factor mcm5 - xenopus laevis (Protein from Xenopus laevis)
- Dna replication licensing factor mcm2 - xenopus laevis (Protein from Xenopus laevis)
- Dna replication complex gins protein psf1 - xenopus laevis (Protein from Xenopus laevis)
- Dna replication complex gins protein psf3 - xenopus laevis (Protein from Xenopus laevis)
- Single cmg purified from replicating xenopus egg extracts (700 kDa, Complex from Xenopus laevis)
- Cell division control protein 45 - xenopus laevis (Protein from Xenopus laevis)
- Dna replication licensing factor mcm7 - xenopus laevis (Protein from Xenopus laevis)
- Dna replication licensing factor mcm6 - xenopus laevis (Protein from Xenopus laevis)
- Dna replication licensing factor mcm4 - xenopus laevis (Protein from Xenopus laevis)
Resolution: 3.75 Å
EM Method: Single-particle
Fitted PDBs: 8ouw
Q-score: 0.329
Xia Y, Sonneville R, Jenkyn-Bedford M, Ji L, Alabert C, Hong Y, Yeeles JTP, Labib KPM
Science (2023) 381 pp. eadi4932-eadi4932 [ DOI: doi:10.1126/science.adi4932 Pubmed: 37590372 ]
- Dna replication licensing factor mcm-5 (85 kDa, Protein from Caenorhabditis elegans)
- Dna replication complex gins protein psf3 (21 kDa, Protein from Caenorhabditis elegans)
- Cell division control protein 45 homolog (66 kDa, Protein from Caenorhabditis elegans)
- Dna replication licensing factor mcm2 (99 kDa, Protein from Caenorhabditis elegans)
- Dna replication licensing factor mcm-4 (91 kDa, Protein from Caenorhabditis elegans)
- Dna replication licensing factor mcm7 (81 kDa, Protein from Caenorhabditis elegans)
- Complex of cmg helicase bound to tim-1/tipn-1 and homodimeric dnsn-1 on fork dna (caenorhabditis elegans) (Complex from Caenorhabditis elegans)
- Magnesium ion (24 Da, Ligand)
- Dna leading strand template (26 kDa, DNA from Saccharomyces cerevisiae)
- Downstream neighbor of son homolog (66 kDa, Protein from Caenorhabditis elegans)
- Probable dna replication complex gins protein psf2 (20 kDa, Protein from Caenorhabditis elegans)
- Dna replication licensing factor mcm3 (90 kDa, Protein from Caenorhabditis elegans)
- Protein tipin homolog (27 kDa, Protein from Caenorhabditis elegans)
- Zinc ion (65 Da, Ligand)
- Dna replication licensing factor mcm-6 (91 kDa, Protein from Caenorhabditis elegans)
- Probable dna replication complex gins protein psf1 (23 kDa, Protein from Caenorhabditis elegans)
- Dna replication complex gins protein sld5 (25 kDa, Protein from Caenorhabditis elegans)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Dna lagging strand template (18 kDa, DNA from Saccharomyces cerevisiae)
- Protein timeless homolog (157 kDa, Protein from Caenorhabditis elegans)
Structure of MCM2-7 DH complexed with Cdc7-Dbf4 in the presence of ATPgS, state III (composite map)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7pt6
Q-score: 0.525
Saleh A, Noguchi Y, Aramayo R, Ivanova ME, Stevens KM, Montoya A, Sunidhi S, Carranza NL, Skwark MJ, Speck C
Nat Commun (2022) 13 pp. 2915-2915 [ Pubmed: 35614055 DOI: doi:10.1038/s41467-022-30576-1 ]
- Undefined mcm4 flexible n-terminal tail (358 Da, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna replication licensing factor mcm7 (95 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Magnesium ion (24 Da, Ligand)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Cell division control protein 7 (58 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna replication licensing factor mcm6 (113 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna replication licensing factor mcm3 (107 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Ddk kinase regulatory subunit dbf4 (80 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna replication licensing factor mcm2 (98 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna replication licensing factor mcm4 (105 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Minichromosome maintenance protein 5 (86 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Mcm2-7 double hexamer bound to two copies of cdc7-dbf4 (1 MDa, Complex from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Structure of MCM2-7 DH complexed with Cdc7-Dbf4 in the presence of ADP:BeF3, state I (composite map)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7pt7
Q-score: 0.445
Saleh A, Noguchi Y, Aramayo R, Ivanova ME, Stevens KM, Montoya A, Sunidhi S, Carranza NL, Skwark MJ, Speck C
Nat Commun (2022) 13 pp. 2915-2915 [ Pubmed: 35614055 DOI: doi:10.1038/s41467-022-30576-1 ]
- Undefined mcm4 flexible n-terminal tail (358 Da, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna replication licensing factor mcm7 (95 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Magnesium ion (24 Da, Ligand)
- Cell division control protein 7 (58 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna replication licensing factor mcm6 (113 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna replication licensing factor mcm3 (107 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Mcm2-7 double hexamer bound to one copy of cdc7-dbf4 (1 MDa, Complex from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Beryllium trifluoride ion (66 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Ddk kinase regulatory subunit dbf4 (80 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna replication licensing factor mcm2 (98 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Dna replication licensing factor mcm4 (105 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Minichromosome maintenance protein 5 (86 kDa, Protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
Saleh A, Noguchi Y, Aramayo R, Ivanova ME, Stevens KM, Montoya A, Sunidhi S, Carranza NL, Skwark MJ, Speck C
Nat Commun (2022) 13 pp. 2915-2915 [ Pubmed: 35614055 DOI: doi:10.1038/s41467-022-30576-1 ]
- Cell division control protein 7 (Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm4 (Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm3 (Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm7 (Protein from Saccharomyces cerevisiae)
- Mcm2-7 double hexamer bound to two copies of cdc7-dbf4 (1 MDa, Complex from Saccharomyces cerevisiae)
- Ddk kinase regulatory subunit dbf4 (Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm5 (Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm6 (Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm2 (Protein from Saccharomyces cerevisiae)
Structure of MCM2-7 DH complexed with Cdc7-Dbf4 in the presence of ATPgS, state II (composite map)
Saleh A, Noguchi Y, Aramayo R, Ivanova ME, Stevens KM, Montoya A, Sunidhi S, Carranza NL, Skwark MJ, Speck C
Nat Commun (2022) 13 pp. 2915-2915 [ Pubmed: 35614055 DOI: doi:10.1038/s41467-022-30576-1 ]
- Cell division control protein 7 (Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm4 (Protein from Saccharomyces cerevisiae)
- Mcm2-7 double hexamer bound to one copy of cdc7-dbf4 and one copy of the dbf4 hbrct domain (1 MDa, Complex from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm3 (Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm7 (Protein from Saccharomyces cerevisiae)
- Ddk kinase regulatory subunit dbf4 (Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm5 (Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm6 (Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm2 (Protein from Saccharomyces cerevisiae)