Resolution: 6.1 Å
EM Method: Single-particle
Fitted PDBs: 9bcx
Q-score: 0.133
Faull SV, Barbon M, Mossler A, Yuan Z, Bai L, Reuter LM, Riera A, Winkler C, Magdalou I, Peach M, Li H, Speck C
Nat Commun (2025) 16 pp. 14-14 [ Pubmed: 39747125 DOI: doi:10.1038/s41467-024-55479-1 ]
- Origin recognition complex subunit 1 (104 kDa, Protein from Saccharomyces cerevisiae)
- Dna (39-mer) (12 kDa, DNA from synthetic construct)
- Dna replication licensing factor mcm6 (113 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm7 (95 kDa, Protein from Saccharomyces cerevisiae)
- Cell division control protein 6 (58 kDa, Protein from Saccharomyces cerevisiae)
- Magnesium ion (24 Da, Ligand)
- Origin recognition complex subunit 5 (55 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm4 (105 kDa, Protein from Saccharomyces cerevisiae)
- Dna (39-mer) (11 kDa, DNA from synthetic construct)
- Dna replication licensing factor mcm2 (98 kDa, Protein from Saccharomyces cerevisiae)
- Origin recognition complex subunit 3 (72 kDa, Protein from Saccharomyces cerevisiae)
- Origin recognition complex subunit 2 (71 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm3 (107 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm5 (86 kDa, Protein from Saccharomyces cerevisiae)
- Origin recognition complex subunit 6 (50 kDa, Protein from Saccharomyces cerevisiae)
- Tah11 isoform 1 (68 kDa, Protein from Saccharomyces cerevisiae)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Orc-cdc6-mcm2-7-dsdna (Complex from Saccharomyces cerevisiae)
- Origin recognition complex subunit 4 (60 kDa, Protein from Saccharomyces cerevisiae)
Cryo-EM map of mutant Mcm2-7 hexamer with Mcm6 WHD truncation
Resolution: 7.7 Å
EM Method: Single-particle
Fitted PDBs: 6wgf
Q-score: 0.064
Yuan Z, Schneider S, Dodd T, Riera A, Bai L, Yan C, Magdalou I, Ivanov I, Stillman B, Li H, Speck C
PNAS (2020) 117 pp. 17747-17756 [ Pubmed: 32669428 DOI: doi:10.1073/pnas.2006231117 ]
- Dna replication licensing factor mcm4 (105 kDa, Protein from Saccharomyces cerevisiae)
- Minichromosome maintenance protein 5 (86 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm2 (98 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm3 (107 kDa, Protein from Saccharomyces cerevisiae)
- Mcm2-7 (Complex from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm6 (113 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm7 (95 kDa, Protein from Saccharomyces cerevisiae)
Cryo-EM map of pre-insertion mutant OCCM-DNA complex (ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation)
Resolution: 8.1 Å
EM Method: Single-particle
Fitted PDBs: 6wgg
Q-score: 0.104
Yuan Z, Schneider S, Dodd T, Riera A, Bai L, Yan C, Magdalou I, Ivanov I, Stillman B, Li H, Speck C
PNAS (2020) 117 pp. 17747-17756 [ Pubmed: 32669428 DOI: doi:10.1073/pnas.2006231117 ]
- Origin recognition complex subunit 5 (55 kDa, Protein from Saccharomyces cerevisiae)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Origin recognition complex subunit 2 (71 kDa, Protein from Saccharomyces cerevisiae)
- Orc-cdc6-mcm2-7-dsdna (Complex from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm4 (105 kDa, Protein from Saccharomyces cerevisiae)
- Dna (41-mer) (12 kDa, DNA from Saccharomyces cerevisiae)
- Dna (41-mer) (12 kDa, DNA from Saccharomyces cerevisiae)
- Origin recognition complex subunit 1 (104 kDa, Protein from Saccharomyces cerevisiae)
- Minichromosome maintenance protein 5 (86 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm2 (98 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm3 (107 kDa, Protein from Saccharomyces cerevisiae)
- Cell division cycle protein cdt1 (68 kDa, Protein from Saccharomyces cerevisiae)
- Origin recognition complex subunit 3 (72 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm6 (113 kDa, Protein from Saccharomyces cerevisiae)
- Origin recognition complex subunit 4 (60 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm7 (95 kDa, Protein from Saccharomyces cerevisiae)
- Origin recognition complex subunit 6 (50 kDa, Protein from Saccharomyces cerevisiae)
- Cell division control protein 6 (58 kDa, Protein from Saccharomyces cerevisiae)
Resolution: 10.0 Å
EM Method: Single-particle
Fitted PDBs: 6wgi
Q-score: 0.086
Yuan Z, Schneider S, Dodd T, Riera A, Bai L, Yan C, Magdalou I, Ivanov I, Stillman B, Li H, Speck C
PNAS (2020) 117 pp. 17747-17756 [ Pubmed: 32669428 DOI: doi:10.1073/pnas.2006231117 ]
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Dna (34-mer) (10 kDa, DNA from Saccharomyces cerevisiae)
- Cell division cycle protein cdt1 (68 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm6 (113 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm7 (95 kDa, Protein from Saccharomyces cerevisiae)
- Cell division control protein 6 (58 kDa, Protein from Saccharomyces cerevisiae)
- Magnesium ion (24 Da, Ligand)
- Origin recognition complex subunit 5 (55 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm4 (105 kDa, Protein from Saccharomyces cerevisiae)
- Minichromosome maintenance protein 5 (86 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm2 (98 kDa, Protein from Saccharomyces cerevisiae)
- Origin recognition complex subunit 3 (72 kDa, Protein from Saccharomyces cerevisiae)
- Origin recognition complex subunit 2 (71 kDa, Protein from Saccharomyces cerevisiae)
- Orc-cdc6-mcm-cdt1-dsdna (Complex from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm3 (107 kDa, Protein from Saccharomyces cerevisiae)
- Dna (34-mer) (10 kDa, DNA from Saccharomyces cerevisiae)
- Origin recognition complex subunit 6 (50 kDa, Protein from Saccharomyces cerevisiae)
- Origin recognition complex subunit 1 (104 kDa, Protein from Saccharomyces cerevisiae)
- Origin recognition complex subunit 4 (60 kDa, Protein from Saccharomyces cerevisiae)
Structure of the S. cerevisiae replicative helicase CMG in complex with a forked DNA
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6u0m
Q-score: 0.219
Yuan Z, Georgescu R, Bai L, Zhang D, Li H, O'Donnell ME
Nat Commun (2020) 11 pp. 688- [ DOI: doi:10.1038/s41467-020-14577-6 ]
- Minichromosome maintenance protein 5 (74 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm2 (74 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication complex gins protein psf2 (23 kDa, Protein from Saccharomyces cerevisiae)
- Dna (26-mer) (7 kDa, DNA from Saccharomyces cerevisiae)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Dna (15-mer) (4 kDa, DNA from Saccharomyces cerevisiae)
- Dna replication complex gins protein psf3 (21 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication complex gins protein psf1 (24 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm7 (82 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm4 (85 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm3 (79 kDa, Protein from Saccharomyces cerevisiae)
- Cmg-forkdna (Complex from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm6 (73 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication complex gins protein sld5 (33 kDa, Protein from Saccharomyces cerevisiae)
- Cell division control protein 45 (73 kDa, Protein from Saccharomyces cerevisiae)
Structure of Ctf4 trimer in complex with three CMG helicases
Resolution: 7.0 Å
EM Method: Single-particle
Fitted PDBs: 6pto
Q-score: 0.087
Yuan Z, Georgescu R, Santos RLA, Zhang D, Bai L, Yao NY, Zhao G, O'Donnell ME, Li H
eLife (2019) 8 [ Pubmed: 31589141 DOI: doi:10.7554/eLife.47405 ]
- Cmg-cmg-cmg-ctf4 (Complex from Saccharomyces cerevisiae)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Dna replication licensing factor mcm4 (105 kDa, Protein from Saccharomyces cerevisiae)
- Minichromosome maintenance protein 5 (86 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication complex gins protein psf1 (24 kDa, Protein from Saccharomyces cerevisiae)
- Dna polymerase alpha-binding protein (104 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication complex gins protein psf3 (21 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication complex gins protein psf2 (25 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm2 (98 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm3 (107 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm6 (113 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication licensing factor mcm7 (95 kDa, Protein from Saccharomyces cerevisiae)
- Cell division control protein 45 (74 kDa, Protein from Saccharomyces cerevisiae)
- Dna replication complex gins protein sld5 (33 kDa, Protein from Saccharomyces cerevisiae)
D. melanogaster CMG-DNA with ATP, State 2B
Resolution: 4.46 Å
EM Method: Single-particle
Fitted PDBs: 6raz
Q-score: 0.246
Eickhoff P, Kose HB, Martino F, Petojevic T, Abid Ali F, Locke J, Tamberg N, Nans A, Berger JM, Botchan MR, Yardimci H, Costa A
Cell Rep (2019) 28 pp. 2673-2688.e8 [ Pubmed: 31484077 DOI: doi:10.1016/j.celrep.2019.07.104 ]
- Cdc45l (65 kDa, Protein from Drosophila melanogaster)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Dna replication licensing factor mcm6 (92 kDa, Protein from Drosophila melanogaster)
- Dna replication licensing factor mcm2 (100 kDa, Protein from Drosophila melanogaster)
- Dna (Complex from Drosophila melanogaster)
- Dna (573 Da, DNA from Drosophila melanogaster)
- Dna replication complex gins protein sld5 (26 kDa, Protein from Drosophila melanogaster)
- Dna replication licensing factor mcm5 (82 kDa, Protein from Drosophila melanogaster)
- Dna replication licensing factor mcm4 (96 kDa, Protein from Drosophila melanogaster)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Dna (6 kDa, DNA from Drosophila melanogaster)
- At18545p (24 kDa, Protein from Drosophila melanogaster)
- Dna replication licensing factor mcm3 (91 kDa, Protein from Drosophila melanogaster)
- Cmg helicase bound to forked dna in the presence of atp, state 2b (Complex)
- Dna replication licensing factor mcm7 (81 kDa, Protein from Drosophila melanogaster)
- Cmg helicase (Complex from Drosophila melanogaster)
- Probable dna replication complex gins protein psf2 (23 kDa, Protein from Drosophila melanogaster)
- Ip07275p (23 kDa, Protein from Drosophila melanogaster)
D. melanogaster CMG-DNA with ATP, State 1A
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6raw
Q-score: 0.215
Eickhoff P, Kose HB, Martino F, Petojevic T, Abid Ali F, Locke J, Tamberg N, Nans A, Berger JM, Botchan MR, Yardimci H, Costa A
Cell Rep (2019) 28 pp. 2673-2688.e8 [ Pubmed: 31484077 DOI: doi:10.1016/j.celrep.2019.07.104 ]
- Dna (5'-d(p*tp*cp*gp*ap*tp*cp*gp*ap*tp*cp*gp*ap*t)-3') (3 kDa, DNA from Drosophila melanogaster)
- Cdc45l (65 kDa, Protein from Drosophila melanogaster)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Dna replication licensing factor mcm2 (100 kDa, Protein from Drosophila melanogaster)
- Dna replication licensing factor mcm6 (92 kDa, Protein from Drosophila melanogaster)
- Probable dna replication complex gins protein psf2 (23 kDa, Protein from Drosophila melanogaster)
- Dna (Complex from Drosophila melanogaster)
- Dna replication licensing factor mcm4 (96 kDa, Protein from Drosophila melanogaster)
- Dna replication complex gins protein sld5 (26 kDa, Protein from Drosophila melanogaster)
- Dna replication licensing factor mcm5 (82 kDa, Protein from Drosophila melanogaster)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Dna (7 kDa, DNA from Drosophila melanogaster)
- Cmg helicase bound to forked dna in the presence of atp, state 1a (Complex)
- At18545p (24 kDa, Protein from Drosophila melanogaster)
- Dna replication licensing factor mcm3 (91 kDa, Protein from Drosophila melanogaster)
- Dna replication licensing factor mcm7 (81 kDa, Protein from Drosophila melanogaster)
- Cmg helicase (Complex from Drosophila melanogaster)
- Ip07275p (23 kDa, Protein from Drosophila melanogaster)
D. melanogaster CMG-DNA with ATP, State 1B
Resolution: 3.99 Å
EM Method: Single-particle
Fitted PDBs: 6rax
Q-score: 0.255
Eickhoff P, Kose HB, Martino F, Petojevic T, Abid Ali F, Locke J, Tamberg N, Nans A, Berger JM, Botchan MR, Yardimci H, Costa A
Cell Rep (2019) 28 pp. 2673-2688.e8 [ Pubmed: 31484077 DOI: doi:10.1016/j.celrep.2019.07.104 ]
- Cdc45l (65 kDa, Protein from Drosophila melanogaster)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Dna replication licensing factor mcm2 (100 kDa, Protein from Drosophila melanogaster)
- Dna replication licensing factor mcm6 (92 kDa, Protein from Drosophila melanogaster)
- Probable dna replication complex gins protein psf2 (23 kDa, Protein from Drosophila melanogaster)
- Dna (Complex from Drosophila melanogaster)
- Dna replication licensing factor mcm4 (96 kDa, Protein from Drosophila melanogaster)
- Dna (2 kDa, DNA from Drosophila melanogaster)
- Dna replication licensing factor mcm5 (82 kDa, Protein from Drosophila melanogaster)
- Dna replication complex gins protein sld5 (26 kDa, Protein from Drosophila melanogaster)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- At18545p (24 kDa, Protein from Drosophila melanogaster)
- Dna replication licensing factor mcm3 (91 kDa, Protein from Drosophila melanogaster)
- Cmg helicase bound to forked dna in the presence of atp, state 1b (Complex)
- Dna replication licensing factor mcm7 (81 kDa, Protein from Drosophila melanogaster)
- Dna (6 kDa, DNA from Drosophila melanogaster)
- Cmg helicase (Complex from Drosophila melanogaster)
- Ip07275p (23 kDa, Protein from Drosophila melanogaster)
D. melanogaster CMG-DNA with ATP, State 2A
Resolution: 4.28 Å
EM Method: Single-particle
Fitted PDBs: 6ray
Q-score: 0.235
Eickhoff P, Kose HB, Martino F, Petojevic T, Abid Ali F, Locke J, Tamberg N, Nans A, Berger JM, Botchan MR, Yardimci H, Costa A
Cell Rep (2019) 28 pp. 2673-2688.e8 [ Pubmed: 31484077 DOI: doi:10.1016/j.celrep.2019.07.104 ]
- Cdc45l (65 kDa, Protein from Drosophila melanogaster)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Cmg helicase bound to forked dna in the presence of atp, state 2a (Complex)
- Dna replication licensing factor mcm6 (92 kDa, Protein from Drosophila melanogaster)
- Probable dna replication complex gins protein psf2 (23 kDa, Protein from Drosophila melanogaster)
- Dna (Complex from Drosophila melanogaster)
- Dna replication licensing factor mcm4 (96 kDa, Protein from Drosophila melanogaster)
- Dna replication complex gins protein sld5 (26 kDa, Protein from Drosophila melanogaster)
- Dna replication licensing factor mcm5 (82 kDa, Protein from Drosophila melanogaster)
- Dna replication licensing factor mcm2 (100 kDa, Protein from Drosophila melanogaster)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- At18545p (24 kDa, Protein from Drosophila melanogaster)
- Dna replication licensing factor mcm3 (91 kDa, Protein from Drosophila melanogaster)
- Dna (5'-d(p*ap*tp*tp*tp*tp*tp*tp*tp*tp*tp*tp*tp*t)-3') (3 kDa, DNA from Drosophila melanogaster)
- Dna replication licensing factor mcm7 (81 kDa, Protein from Drosophila melanogaster)
- Cmg helicase (Complex from Drosophila melanogaster)
- Ip07275p (23 kDa, Protein from Drosophila melanogaster)