MutSbeta bound to (CAG)2 DNA (open form)
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 8om9
Q-score: 0.249
Lee J-H, Thomsen M, Daub H, Steinbacher S, Sztyler A, Thieulin-Pardo G, Neudegger T, Plotnikov N, Iyer RR, Wilkinson H, Monteagudo E, Felsenfeld DP, Haque T, Finley M, Dominguez C, Vogt TF, Prasad BC
To Be Published
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Dna1 (8 kDa, DNA from Homo sapiens)
- Mutsbeta bound to (cag)2 dna (open form) (Complex from Homo sapiens)
- Dna2 (6 kDa, DNA from Homo sapiens)
- Dna mismatch repair protein msh3 (127 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Dna mismatch repair protein msh2 (104 kDa, Protein from Homo sapiens)
Bulky DNA lesion recognition complex 3
Kim J, Li CL, Chen X, Cui Y, Golebiowski FM, Wang H, Hanaoka F, Sugasawa K, Yang W
Nature (2023) 617 pp. 170-175 [ Pubmed: 37076618 DOI: doi:10.1038/s41586-023-05959-z ]
- Dna repair protein complementing xp-a cells (Protein from Homo sapiens)
- General transcription factor iih subunit 1 (Protein from Homo sapiens)
- Bulky dna lesion recognition complex 3 (440 kDa, Complex from Homo sapiens)
- Dna2 (DNA from synthetic construct)
- General transcription factor iih subunit 5 (Protein from Homo sapiens)
- General transcription factor iih subunit 2 (Protein from Homo sapiens)
- Tfiih basal transcription factor complex helicase xpd subunit (Protein from Homo sapiens)
- General transcription factor iih subunit 3 (Protein from Homo sapiens)
- Dna repair protein complementing xp-c cells (Protein from Homo sapiens)
- General transcription factor iih subunit 4 (Protein from Homo sapiens)
- Dna1 (DNA from synthetic construct)
- General transcription and dna repair factor iih helicase subunit xpb (Protein from Homo sapiens)
Initial DNA-lesion (Cy5) binding by XPC and TFIIH focused
Kim J, Li CL, Chen X, Cui Y, Golebiowski FM, Wang H, Hanaoka F, Sugasawa K, Yang W
Nature (2023) 617 pp. 170-175 [ Pubmed: 37076618 DOI: doi:10.1038/s41586-023-05959-z ]
- General transcription factor iih subunit 1 (Protein from Homo sapiens)
- Dna2 (DNA from synthetic construct)
- General transcription factor iih subunit 5 (Protein from Homo sapiens)
- Uv excision repair protein rad23 homolog b (Protein from Homo sapiens)
- General transcription factor iih subunit 2 (Protein from Homo sapiens)
- Tfiih basal transcription factor complex helicase xpd subunit (Protein from Homo sapiens)
- General transcription factor iih subunit 3 (Protein from Homo sapiens)
- Centrin-2 (Protein from Homo sapiens)
- Dna repair protein complementing xp-c cells (Protein from Homo sapiens)
- General transcription factor iih subunit 4 (Protein from Homo sapiens)
- Dna1 (DNA from synthetic construct)
- General transcription and dna repair factor iih helicase subunit xpb (Protein from Homo sapiens)
- Bulky dna lesion recognition complex 1 (270 kDa, Complex from Homo sapiens)
XPC release from Core7-XPA-DNA (Cy5)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8ebu
Q-score: 0.341
Kim J, Li CL, Chen X, Cui Y, Golebiowski FM, Wang H, Hanaoka F, Sugasawa K, Yang W
Nature (2023) 617 pp. 170-175 [ Pubmed: 37076618 DOI: doi:10.1038/s41586-023-05959-z ]
- General transcription factor iih subunit 3 (34 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Bulky dna lesion recognition complex3 (Complex from Homo sapiens)
- Tfiih basal transcription factor complex helicase xpb subunit (89 kDa, Protein from Homo sapiens)
- Dna repair protein complementing xp-c cells (107 kDa, Protein from Homo sapiens)
- General transcription factor iih subunit 5 (8 kDa, Protein from Homo sapiens)
- General transcription factor iih subunit 1 (62 kDa, Protein from Homo sapiens)
- Dna repair protein complementing xp-a cells (31 kDa, Protein from Homo sapiens)
- General transcription factor iih subunit 2 (46 kDa, Protein from Homo sapiens)
- General transcription and dna repair factor iih helicase subunit xpd (88 kDa, Protein from Homo sapiens)
- Iron/sulfur cluster (351 Da, Ligand)
- General transcription factor iih subunit 4, p52 (52 kDa, Protein from Homo sapiens)
- Dna1 (7 kDa, DNA from synthetic construct)
- Dna2 (7 kDa, DNA from synthetic construct)
Closed linker DNA nucleosome reconstituted with GUB DNA
Arimura Y, Shih RM, Froom R, Funabiki H
Mol Cell (2021) 81 pp. 4377-4397.e12 [ Pubmed: 34478647 DOI: doi:10.1016/j.molcel.2021.08.010 ]
- H3.2 (Protein from Xenopus laevis)
- Gub dna (DNA from synthetic construct)
- H2a (Protein from Xenopus laevis)
- Closed linker dna nucleosome reconstituted with gub dna (Complex from Xenopus laevis)
- H4 (Protein from Xenopus laevis)
- Gub dna_2 (DNA from synthetic construct)
- H2b (Protein from Xenopus laevis)
Open linker DNA nucleosome reconstituted with GUB DNA
Arimura Y, Shih RM, Froom R, Funabiki H
Mol Cell (2021) 81 pp. 4377-4397.e12 [ Pubmed: 34478647 DOI: doi:10.1016/j.molcel.2021.08.010 ]
- Gub_dna_2 (DNA from synthetic construct)
- H3.2 (Protein from Xenopus laevis)
- Open linker dna nucleosome reconstituted with gub dna (Complex from Xenopus laevis)
- H2a (Protein from Xenopus laevis)
- H4 (Protein from Xenopus laevis)
- Gub_dna (DNA from synthetic construct)
- H2b (Protein from Xenopus laevis)