Cryo-EM structure of DNMT5 in apo state
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7r76
Q-score: 0.479
Wang J, Catania S, Wang C, de la Cruz MJ, Rao B, Madhani HD, Patel DJ
Mol Cell (2022) 82 pp. 1186-1198.e6 [ Pubmed: 35202575 DOI: doi:10.1016/j.molcel.2022.01.028 ]
- Dna repair protein rad8 (263 kDa, Protein from Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487))
- Zinc ion (65 Da, Ligand)
- Dnmt5 (260 kDa, Complex from Cryptococcus neoformans)
Cryo-EM structure of DNMT5 binary complex with hemimethylated DNA
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7r77
Q-score: 0.548
Wang J, Catania S, Wang C, de la Cruz MJ, Rao B, Madhani HD, Patel DJ
Mol Cell (2022) 82 pp. 1186-1198.e6 [ Pubmed: 35202575 DOI: doi:10.1016/j.molcel.2022.01.028 ]
- Dna repair protein rad8 (263 kDa, Protein from Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487))
- Dna (5'-d(p*gp*tp*cp*ap*gp*(5cm)p*gp*cp*ap*tp*gp*g)-3') (11 kDa, DNA from Cryptococcus neoformans)
- Zinc ion (65 Da, Ligand)
- Dnmt5 (260 kDa, Complex from Cryptococcus neoformans)
- Dna (5'-d(p*gp*tp*cp*ap*gp*(5cm)p*gp*cp*ap*tp*gp*g)-3') (10 kDa, DNA from Cryptococcus neoformans)
Cryo-EM structure of DNMT5 quaternary complex with hemimethylated DNA, AMP-PNP and SAH
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7r78
Q-score: 0.498
Wang J, Catania S, Wang C, de la Cruz MJ, Rao B, Madhani HD, Patel DJ
Mol Cell (2022) 82 pp. 1186-1198.e6 [ Pubmed: 35202575 DOI: doi:10.1016/j.molcel.2022.01.028 ]
- Dna (5'-d(*tp*gp*cp*gp*cp*tp*gp*ap*cp*a)-3') (10 kDa, DNA from Cryptococcus neoformans)
- Magnesium ion (24 Da, Ligand)
- Dna repair protein rad8 (263 kDa, Protein from Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487))
- Dnmt5 in complex with hemimethylated dna, amp-pnp and sah (260 kDa, Complex from Cryptococcus neoformans)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Dna (5'-d(p*cp*ap*gp*(5cm)p*gp*cp*ap*t)-3') (11 kDa, DNA from Cryptococcus neoformans)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7t02
Q-score: 0.477
Wang J, Catania S, Wang C, de la Cruz MJ, Rao B, Madhani HD, Patel DJ
Mol Cell (2022) 82 pp. 1186-1198.e6 [ Pubmed: 35202575 DOI: doi:10.1016/j.molcel.2022.01.028 ]
- Dnmt5 (260 kDa, Complex from Cryptococcus neoformans)
- Dna repair protein rad8 (263 kDa, Protein from Cryptococcus neoformans var. grubii H99)
- Dna (5'-d(p*gp*tp*cp*ap*gp*(5cm)p*gp*cp*ap*tp*gp*g)-3') (11 kDa, DNA from Cryptococcus neoformans)
- Zinc ion (65 Da, Ligand)
- Dna (5'-d(*cp*cp*ap*tp*gp*cp*gp*cp*tp*gp*ap*cp*a)-3') (10 kDa, DNA from Cryptococcus neoformans)