Cytoplasmic dynein-B heavy chain bound to IC-LC tower
Resolution: 8.2 Å
EM Method: Single-particle
Fitted PDBs: 8pr1
Q-score: 0.193
Singh K, Lau CK, Manigrasso G, Gama JB, Gassmann R, Carter AP
Science (2024) 383 pp. eadk8544-eadk8544 [ DOI: doi:10.1126/science.adk8544 Pubmed: 38547289 ]
- Cytoplasmic dynein 1 heavy chain 1 (533 kDa, Protein from Homo sapiens)
- Cytoplasmic dynein 1 light intermediate chain 2 (54 kDa, Protein from Homo sapiens)
- Dynein light chain 1, cytoplasmic (10 kDa, Protein from Homo sapiens)
- Cytoplasmic dynein 1 intermediate chain 2 (68 kDa, Protein from Homo sapiens)
- Dynein light chain tctex-type 1 (12 kDa, Protein from Homo sapiens)
- Cytoplasmic dynein-a heavy chain bound to dynactin p150 and ic-lc tower (Complex from Homo sapiens)
- Dynein light chain roadblock-type 1 (10 kDa, Protein from Homo sapiens)
Composite structure of Dynein-Dynactin-JIP3-LIS1
Resolution: 10.0 Å
EM Method: Single-particle
Fitted PDBs: 8ptk
Q-score: 0.202
Singh K, Lau CK, Manigrasso G, Gama JB, Gassmann R, Carter AP
Science (2024) 383 pp. eadk8544-eadk8544 [ DOI: doi:10.1126/science.adk8544 Pubmed: 38547289 ]
- Arp1 actin related protein 1 homolog a (42 kDa, Protein from Sus scrofa)
- Dynactin subunit 3 (21 kDa, Protein from Sus scrofa)
- Dynein and jip3 (Complex from Homo sapiens)
- Capping protein (actin filament) muscle z-line, alpha 1 (33 kDa, Protein from Sus scrofa)
- Zinc ion (65 Da, Ligand)
- Platelet-activating factor acetylhydrolase ib subunit beta (46 kDa, Protein from Homo sapiens)
- Composite structure of dynein-dynactin-jip3-lis1 (Complex)
- Cytoplasmic dynein 1 light intermediate chain 2 (54 kDa, Protein from Homo sapiens)
- Dynactin 6 (20 kDa, Protein from Sus scrofa)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Arp11 (46 kDa, Protein from Sus scrofa)
- C-jun-amino-terminal kinase-interacting protein 3 (65 kDa, Protein from Homo sapiens)
- Dynactin subunit 2 (44 kDa, Protein from Sus scrofa)
- Cytoplasmic dynein 1 heavy chain 1 (533 kDa, Protein from Homo sapiens)
- F-actin-capping protein subunit beta (30 kDa, Protein from Sus scrofa)
- Cytoplasmic dynein 1 intermediate chain 2 (68 kDa, Protein from Homo sapiens)
- Dynein light chain tctex-type 1 (12 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Dynein light chain roadblock-type 1 (10 kDa, Protein from Homo sapiens)
- Dynactin subunit 5 (20 kDa, Protein from Sus scrofa)
- Actin, cytoplasmic 1 (41 kDa, Protein from Sus scrofa)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Dynein light chain 1, cytoplasmic (10 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Dynactin subunit 4 (52 kDa, Protein from Sus scrofa)
- Dynactin subunits (Complex from Sus scrofa)
- Dynactin subunit 1 (142 kDa, Protein from Sus scrofa)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8rgg
Q-score: 0.26
Mukhopadhyay AG, Toropova K, Daly L, Wells JN, Vuolo L, Mladenov M, Seda M, Jenkins D, Stephens DJ, Roberts AJ
EMBO J (2024) 43 pp. 1257-1272 [ Pubmed: 38454149 DOI: doi:10.1038/s44318-024-00060-1 ]
- Cytoplasmic dynein 2 intermediate chain 2 (60 kDa, Protein from Homo sapiens)
- Cytoplasmic dynein 2 intermediate chain 1 (122 kDa, Protein from Homo sapiens)
- Methylated-dna--protein-cysteine methyltransferase,cytoplasmic dynein 2 heavy chain 1 (515 kDa, Protein from Homo sapiens)
- Dynein-2 complex (Complex from Homo sapiens)
- Dynein light chain 1, cytoplasmic (10 kDa, Protein from Homo sapiens)
- Dynein light chain roadblock-type 1 (10 kDa, Protein from Homo sapiens)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8rgh
Q-score: 0.315
Mukhopadhyay AG, Toropova K, Daly L, Wells JN, Vuolo L, Mladenov M, Seda M, Jenkins D, Stephens DJ, Roberts AJ
EMBO J (2024) 43 pp. 1257-1272 [ Pubmed: 38454149 DOI: doi:10.1038/s44318-024-00060-1 ]
- Cytoplasmic dynein 2 intermediate chain 2 (60 kDa, Protein from Homo sapiens)
- Cytoplasmic dynein 2 intermediate chain 1 (122 kDa, Protein from Homo sapiens)
- Methylated-dna--protein-cysteine methyltransferase,cytoplasmic dynein 2 heavy chain 1 (515 kDa, Protein from Homo sapiens)
- Dynein-2 complex (Complex from Homo sapiens)
- Cytoplasmic dynein 2 light intermediate chain 1 (39 kDa, Protein from Homo sapiens)
- Dynein light chain roadblock-type 1 (10 kDa, Protein from Homo sapiens)
96nm repeat of human respiratory doublet microtubule and associated axonemal complexes
Walton T, Gui M, Velkova S, Fassad MR, Hirst RA, Haarman E, O'Callaghan C, Bottier M, Burgoyne T, Mitchison HM, Brown A
Nature (2023) 618 pp. 625-633 [ DOI: doi:10.1038/s41586-023-06140-2 Pubmed: 37258679 ]
- Nucleoside diphosphate kinase 7 (42 kDa, Protein from human)
- Piercer of microtubule wall 1 protein (15 kDa, Protein from human)
- Dnaj homolog subfamily b member 13 (36 kDa, Protein from human)
- Cilia- and flagella-associated protein 144 (16 kDa, Protein from human)
- Outer dynein arm-docking complex subunit 4 (76 kDa, Protein from human)
- Leucine-rich repeat-containing protein 34 (51 kDa, Protein from human)
- Cilia- and flagella-associated protein 141 (12 kDa, Protein from human)
- Cilia- and flagella-associated protein 52 (68 kDa, Protein from human)
- Cilia- and flagella-associated protein 107 (23 kDa, Protein from human)
- Coiled-coil domain-containing protein 113 (44 kDa, Protein from human)
- Outer dynein arm-docking complex subunit 3 (69 kDa, Protein from human)
- Ropporin-1-like protein (26 kDa, Protein from human)
- Dynein regulatory complex subunit 4 (56 kDa, Protein from human)
- Probable inactive peptidyl-prolyl cis-trans isomerase-like 6 (35 kDa, Protein from human)
- Ef-hand domain-containing protein 1 (74 kDa, Protein from human)
- Outer dynein arm-docking complex subunit 1 (75 kDa, Protein from human)
- Dynll1 (10 kDa, Protein from human)
- Dynein light chain tctex-type 1 (12 kDa, Protein from human)
- Dynein regulatory complex protein 10 (52 kDa, Protein from human)
- Tektin-1 (48 kDa, Protein from human)
- Ef-hand domain-containing family member b (93 kDa, Protein from human)
- Cytochrome b5 domain-containing protein 1 (26 kDa, Protein from human)
- Cilia- and flagella-associated protein 251 (130 kDa, Protein from human)
- Zinc finger mynd domain-containing protein 12 (41 kDa, Protein from human)
- Uncharacterized protein cfap68 (17 kDa, Protein from human)
- Dynein axonemal intermediate chain 4 (94 kDa, Protein from human)
- Protein flattop (19 kDa, Protein from human)
- Dynein regulatory complex protein 8 (29 kDa, Protein from human)
- Dynein regulatory complex protein 11 (95 kDa, Protein from human)
- Centrin-2 (19 kDa, Protein from human)
- Nucleoside diphosphate kinase homolog 5 (24 kDa, Protein from human)
- Cilia- and flagella-associated protein 53 (61 kDa, Protein from human)
- Cilia- and flagella-associated protein 91 (90 kDa, Protein from human)
- Calmodulin-1 (16 kDa, Protein from human)
- Dynein light chain roadblock-type 2 (10 kDa, Protein from human)
- Acta2 (42 kDa, Protein from human)
- Dynein axonemal heavy chain 3 (471 kDa, Protein from human)
- Dynein regulatory complex protein 9 (52 kDa, Protein from human)
- Cilia- and flagella-associated protein 58 (103 kDa, Protein from human)
- Dynein light chain tctex-type protein 2b (16 kDa, Protein from human)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Sperm-associated antigen 8 (51 kDa, Protein from human)
- Tubulin alpha-1a chain (50 kDa, Protein from human)
- Cilia- and flagella-associated protein 61 (141 kDa, Protein from human)
- Tetratricopeptide repeat protein 29 (55 kDa, Protein from human)
- Cilia- and flagella-associated protein 276 (19 kDa, Protein from human)
- Protein fam166b (30 kDa, Protein from human)
- Tektin-2 (49 kDa, Protein from human)
- Dynein axonemal intermediate chain 3 (103 kDa, Protein from human)
- Cilia- and flagella-associated protein 77 (33 kDa, Protein from human)
- Dynein axonemal intermediate chain 7 (83 kDa, Protein from human)
- Rib43a-like with coiled-coils protein 1 (44 kDa, Protein from human)
- Dynein axonemal intermediate chain 1 (79 kDa, Protein from human)
- Dynein axonemal intermediate chain 2 (68 kDa, Protein from human)
- Cilia- and flagella- associated protein 210 (66 kDa, Protein from human)
- Morn repeat-containing protein 3 (27 kDa, Protein from human)
- Dynein regulatory complex subunit 5 (55 kDa, Protein from human)
- Cilia- and flagella-associated protein 161 (34 kDa, Protein from human)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Parkin coregulated gene protein (29 kDa, Protein from human)
- Radial spoke head 1 homolog (35 kDa, Protein from human)
- Iq and ubiquitin-like domain-containing protein (92 kDa, Protein from human)
- Dynein axonemal heavy chain 12 (454 kDa, Protein from human)
- Meiosis-specific nuclear structural protein 1 (60 kDa, Protein from human)
- Cilia- and flagella-associated protein 73 (35 kDa, Protein from human)
- Dynein regulatory complex subunit 2 (57 kDa, Protein from human)
- Calaxin (24 kDa, Protein from human)
- Piercer of microtubule wall 2 protein (13 kDa, Protein from human)
- Radial spoke head 14 homolog (38 kDa, Protein from human)
- Dynein axonemal heavy chain 7 (461 kDa, Protein from human)
- Cilia- and flagella-associated protein 43 (192 kDa, Protein from human)
- Coiled-coil domain-containing protein 39 (110 kDa, Protein from human)
- Dpy30 domain-containing protein 2 (20 kDa, Protein from human)
- Cilia- and flagella-associated protein 100 (71 kDa, Protein from human)
- Dynein axonemal heavy chain 5 (529 kDa, Protein from human)
- Cilia- and flagella-associated protein 57 (145 kDa, Protein from human)
- Sperm acrosome-associated protein 9 (25 kDa, Protein from human)
- Radial spoke head protein 9 homolog (31 kDa, Protein from human)
- Sperm surface protein sp17 (17 kDa, Protein from human)
- Outer dynein arm-docking complex subunit 2 (115 kDa, Protein from human)
- Radial spoke head protein 3 homolog (63 kDa, Protein from human)
- Radial spoke head protein 4 homolog a (80 kDa, Protein from human)
- Dynein axonemal heavy chain 6 (476 kDa, Protein from human)
- Cilia- and flagella-associated protein 95 (26 kDa, Protein from human)
- Tubulin beta-4b chain (49 kDa, Protein from human)
- Rib43a-like with coiled-coils protein 2 (45 kDa, Protein from human)
- Dynein axonemal heavy chain 10 (529 kDa, Protein from human)
- Cilia- and flagella-associated protein 45 (65 kDa, Protein from human)
- Ef-hand domain-containing family member c2 (87 kDa, Protein from human)
- Coiled-coil domain-containing protein 40 (130 kDa, Protein from human)
- Uncharacterized protein cfap90 (17 kDa, Protein from human)
- Dynein axonemal heavy chain 9 (512 kDa, Protein from human)
- Axonemal complex (Complex from Homo sapiens)
- Dynein regulatory complex subunit 7 (103 kDa, Protein from human)
- Coiled-coil domain-containing protein 96 (62 kDa, Protein from human)
- Dynein axonemal heavy chain 1 (488 kDa, Protein from human)
- Axonemal dynein light intermediate polypeptide 1 (29 kDa, Protein from human)
- Dynein light chain roadblock-type 1 (10 kDa, Protein from human)
- Dynein regulatory complex subunit 3 (61 kDa, Protein from human)
- Cilia- and flagella-associated protein 299 (26 kDa, Protein from human)
- Unknown (6 kDa, Protein from human)
- Protein fam166c (23 kDa, Protein from human)
- Cilia- and flagella-associated protein 20 (22 kDa, Protein from human)
- Dynein axonemal light chain 1 (21 kDa, Protein from human)
- Magnesium ion (24 Da, Ligand)
- Cilia- and flagella-associated protein 44 (214 kDa, Protein from human)
- Enkurin (29 kDa, Protein from human)
- Thioredoxin domain-containing protein 6 (36 kDa, Protein from human)
- Dynein axonemal heavy chain 2 (508 kDa, Protein from human)
- Dynein regulatory complex protein 1 (87 kDa, Protein from human)
Composite structure of dynein-dynactin-BICDR on microtubules
Resolution: 20.0 Å
EM Method: Single-particle
Fitted PDBs: 7z8f
Q-score: 0.215
Nature (2022) 610 pp. 212-216 [ DOI: doi:10.1038/s41586-022-05186-y Pubmed: 36071160 ]
- Arp1 actin related protein 1 homolog a (42 kDa, Protein from Sus scrofa)
- Dynactin subunit 3 (21 kDa, Protein from Sus scrofa)
- Capping protein (actin filament) muscle z-line, alpha 1 (33 kDa, Protein from Sus scrofa)
- Dynactin (1 MDa, Cellular component from Sus scrofa)
- Zinc ion (65 Da, Ligand)
- Complex of dynein, dynactin, and bicdr1 bound to microtubules (4 MDa, Complex)
- Cytoplasmic dynein 1 light intermediate chain 2 (54 kDa, Protein from Homo sapiens)
- Dynactin 6 (20 kDa, Protein from Sus scrofa)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Arp11 (46 kDa, Protein from Sus scrofa)
- F-actin capping protein beta subunit (30 kDa, Protein from Sus scrofa)
- Dynactin subunit 2 (44 kDa, Protein from Sus scrofa)
- Cytoplasmic dynein 1 heavy chain 1 (533 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Bicd family-like cargo adapter 1 (65 kDa, Protein from Mus musculus)
- Dynein light chain roadblock-type 1 (10 kDa, Protein from Homo sapiens)
- Dynein, cytoplasmic 1 (1 MDa, Cellular component from Homo sapiens)
- Cytoplasmic dynein 1 intermediate chain 2 (71 kDa, Protein from Homo sapiens)
- Dynactin subunit 5 (20 kDa, Protein from Sus scrofa)
- Actin, cytoplasmic 1 (41 kDa, Protein from Sus scrofa)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Dynactin subunit 4 (52 kDa, Protein from Sus scrofa)
- Bicdr1 (130 kDa, Cellular component from Mus musculus)
- Dynactin subunit 1 (142 kDa, Protein from Sus scrofa)
Structure of the dynein-2 complex; tail domain
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 6rlb
Q-score: 0.248
Toropova K, Zalyte R, Mukhopadhyay AG, Mladenov M, Carter AP, Roberts AJ
Nat Struct Mol Biol (2019) 26 pp. 823-829 [ DOI: doi:10.1038/s41594-019-0286-y Pubmed: 31451806 ]
- Wd repeat-containing protein 60 (122 kDa, Protein from Homo sapiens)
- O6-alkylguanine-dna alkyltransferase mutant,dync2h1 variant protein (515 kDa, Protein from Homo sapiens)
- Dynein light chain 1, cytoplasmic (10 kDa, Protein from Homo sapiens)
- Cytoplasmic dynein 2 light intermediate chain 1 (39 kDa, Protein from Homo sapiens)
- Dynein-2 complex; tail domain (Complex from Homo sapiens)
- Wd repeat-containing protein 34 (60 kDa, Protein from Homo sapiens)
- Dynein light chain roadblock-type 1 (10 kDa, Protein from Homo sapiens)
Cryo-EM structure of two dynein tail domains bound to dynactin and BICDR1
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6f1t
Q-score: 0.269
Urnavicius L, Lau CK, Elshenawy MM, Morales-Rios E, Motz C, Yildiz A, Carter AP
Nature (2018) 554 pp. 202-206 [ Pubmed: 29420470 DOI: doi:10.1038/nature25462 ]
- Arp1 actin related protein 1 homolog a (42 kDa, Protein from Sus scrofa)
- Capping protein (actin filament) muscle z-line, alpha 1 (33 kDa, Protein from Sus scrofa)
- Cytoplasmic dynein 1 light intermediate chain 2 (54 kDa, Protein from Homo sapiens)
- Dynactin 6 (20 kDa, Protein from Sus scrofa)
- Dynactin subunit 4 (22 kDa, Protein from Sus scrofa)
- Dynactin subunit 2 (52 kDa, Protein from Sus scrofa)
- Bicd family-like cargo adapter 1 (Complex from Mus musculus)
- Dynactin (Complex from Sus scrofa)
- Dynactin subunit 2 (7 kDa, Protein from Sus scrofa)
- F-actin capping protein beta subunit (30 kDa, Protein from Sus scrofa)
- Dynactin subunit 3 (5 kDa, Protein from Sus scrofa)
- Cytoplasmic dynein 1 intermediate chain 2 (68 kDa, Protein from Homo sapiens)
- Dynactin subunit 1 (4 kDa, Protein from Sus scrofa)
- Dynactin subunit 2 (7 kDa, Protein from Sus scrofa)
- Dynactin subunit 2 (5 kDa, Protein from Sus scrofa)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Dynein light chain roadblock-type 1 (10 kDa, Protein from Homo sapiens)
- Dynactin subunit 2 (50 kDa, Protein from Sus scrofa)
- Dynactin subunit 5 (20 kDa, Protein from Sus scrofa)
- Dynactin subunit 1 (4 kDa, Protein from Sus scrofa)
- Actin, cytoplasmic 1 (41 kDa, Protein from Sus scrofa)
- Cryo-em map of two dynein tail domains bound to dynactin and bicdr1 (Complex)
- Bicd family-like cargo adapter 1,bicd family-like cargo adapter 1,bicd family-like cargo adapter 1 (42 kDa, Protein from Mus musculus)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Dynactin subunit 2 (2 kDa, Protein from Sus scrofa)
- Dynein (Complex from Homo sapiens)
- Actin related protein 10 homolog (43 kDa, Protein from Sus scrofa)
- Bicd family-like cargo adapter 1,bicd family-like cargo adapter 1,bicd family-like cargo adapter 1,bicdr-1 (42 kDa, Protein from Mus musculus)
- Cytoplasmic dynein 1 heavy chain 1,cytoplasmic dynein 1 heavy chain 1,cytoplasmic dynein 1 heavy chain 1,dynein heavy chain,cytoplasmic dynein 1 heavy chain 1,cytoplasmic dynein 1 heavy chain 1,cytoplasmic dynein 1 heavy chain 1,cytoplasmic dynein 1 heavy chain 1,dynein heavy chain,cytoplasmic dynein 1 heavy chain 1,cytoplasmic dynein 1 heavy chain 1 (119 kDa, Protein from Homo sapiens)
- Dynactin subunit 2 (10 kDa, Protein from Sus scrofa)
Roadblock-1 region of the dynein tail/dynactin/BICDR1 complex
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6f1z
Q-score: 0.252
Urnavicius L, Lau CK, Elshenawy MM, Morales-Rios E, Motz C, Yildiz A, Carter AP
Nature (2018) 554 pp. 202-206 [ Pubmed: 29420470 DOI: doi:10.1038/nature25462 ]
- Cytoplasmic dynein 1 intermediate chain 2 (68 kDa, Protein from Homo sapiens)
- Two dynein tail domains, dynactin and bicdr1 (Complex from Homo sapiens)
- Dynein light chain roadblock-type 1 (10 kDa, Protein from Homo sapiens)
Cryo-EM structure of two dynein tail domains bound to dynactin and HOOK3
Resolution: 6.7 Å
EM Method: Single-particle
Fitted PDBs: 6f38
Q-score: 0.23
Urnavicius L, Lau CK, Elshenawy MM, Morales-Rios E, Motz C, Yildiz A, Carter AP
Nature (2018) 554 pp. 202-206 [ Pubmed: 29420470 DOI: doi:10.1038/nature25462 ]
- Arp1 actin related protein 1 homolog a (42 kDa, Protein from Sus scrofa)
- Dynactin subunit 2 (3 kDa, Protein from Sus scrofa)
- Complex of two dynein tail domains bound to dynactin and hook3 (Complex)
- Capping protein (actin filament) muscle z-line, alpha 1 (33 kDa, Protein from Sus scrofa)
- Dynactin subunit 2 (10 kDa, Protein from Sus scrofa)
- Cytoplasmic dynein 1 light intermediate chain 2 (54 kDa, Protein from Homo sapiens)
- Dynactin 6 (20 kDa, Protein from Sus scrofa)
- Dynactin subunit 2 (49 kDa, Protein from Sus scrofa)
- Dynactin subunit 4 (22 kDa, Protein from Sus scrofa)
- Dynactin (Complex from Sus scrofa)
- Hook3 (18 kDa, Protein from Homo sapiens)
- Dynactin subunit 2 (7 kDa, Protein from Sus scrofa)
- F-actin capping protein beta subunit (30 kDa, Protein from Sus scrofa)
- Hook3 (Complex from Homo sapiens)
- Dynactin subunit 3 (5 kDa, Protein from Sus scrofa)
- Dynactin subunit 2 (7 kDa, Protein from Sus scrofa)
- Cytoplasmic dynein 1 intermediate chain 2 (68 kDa, Protein from Homo sapiens)
- Dynactin subunit 1 (4 kDa, Protein from Sus scrofa)
- Dynactin subunit 2 (5 kDa, Protein from Sus scrofa)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Dynein light chain roadblock-type 1 (10 kDa, Protein from Homo sapiens)
- Dynactin subunit 1 (4 kDa, Protein from Sus scrofa)
- Dynactin subunit 5 (20 kDa, Protein from Sus scrofa)
- Actin, cytoplasmic 1 (41 kDa, Protein from Sus scrofa)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Dynein (Complex from Homo sapiens)
- Actin related protein 10 homolog (43 kDa, Protein from Sus scrofa)
- Cytoplasmic dynein 1 heavy chain 1 (168 kDa, Protein from Homo sapiens)
- Dynactin subunit 2 (52 kDa, Protein from Sus scrofa)