Resolution: 3.36 Å
EM Method: Single-particle
Fitted PDBs: 9bsu
Q-score: 0.463
Bu F, Ye G, Morsheimer K, Mendoza A, Turner-Hubbard H, Herbst M, Spiller B, Wadzinski BE, Eaton B, Anantpadma M, Yang G, Liu B, Davey R, Li F
PLoS Pathog (2024) 20 pp. e1012817-e1012817 [ Pubmed: 39715280 DOI: doi:10.1371/journal.ppat.1012817 ]
- Ebov gp (Complex from Ebola virus)
- Nanosota-eb1 (Complex from Vicugna pacos)
- Envelope glycoprotein (77 kDa, Protein from Ebola virus)
- Ebov gp/nanosota-eb1 complex (Complex)
- Nanosota-eb1 (15 kDa, Protein from Vicugna pacos)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9bsv
Q-score: 0.536
Bu F, Ye G, Morsheimer K, Mendoza A, Turner-Hubbard H, Herbst M, Spiller B, Wadzinski BE, Eaton B, Anantpadma M, Yang G, Liu B, Davey R, Li F
PLoS Pathog (2024) 20 pp. e1012817-e1012817 [ Pubmed: 39715280 DOI: doi:10.1371/journal.ppat.1012817 ]
- Nanosota-eb2 (15 kDa, Protein from Vicugna pacos)
- Ebov gp/nanosota-eb2 complex (Complex)
- Ebov glycoprotein (Complex from Ebola virus)
- Alpha-d-mannopyranose (180 Da, Ligand)
- Nanosota-eb2 (Complex from Vicugna pacos)
- Envelope glycoprotein (77 kDa, Protein from Ebola virus)
Structure of EBOV GP lacking the mucin-like domain with 2.1.1D5 scFv and 6D6 scFv bound
Resolution: 2.53 Å
EM Method: Single-particle
Fitted PDBs: 8dpl
Q-score: 0.536
Yu X, Hastie KM, Davis CW, Avalos RD, Williams D, Parekh D, Hui S, Mann C, Hariharan C, Takada A, Ahmed R, Saphire EO
Cell Rep (2023) 42 pp. 113366-113366 [ DOI: doi:10.1016/j.celrep.2023.113366 Pubmed: 37938974 ]
- Glycoprotein gp1 (31 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- Structure of ebov gp in complex with 2.1.1d5 scfv and 6d6 scfv (Complex from Ebola virus - Mayinga, Zaire, 1976)
- Glycoprotein gp2 (15 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- 2.1.1d5 heavy chain variable domain (13 kDa, Protein from Homo sapiens)
- 2.1.1d5 light chain variable domain (11 kDa, Protein from Homo sapiens)
- 6d6 single-chain variable fragment (25 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of EBOV GP lacking the mucin-like domain with 1C11 scFv and 1C3 Fab bound
Resolution: 3.59 Å
EM Method: Single-particle
Fitted PDBs: 7swd
Q-score: 0.449
Milligan JC, Davis CW, Yu X, Ilinykh PA, Huang K, Halfmann PJ, Cross RW, Borisevich V, Agans KN, Geisbert JB, Chennareddy C, Goff AJ, Piper AE, Hui S, Shaffer KCL, Buck T, Heinrich ML, Branco LM, Crozier I, Holbrook MR, Kuhn JH, Kawaoka Y, Glass PJ, Bukreyev A, Geisbert TW, Worwa G, Ahmed R, Saphire EO
Cell (2022) 185 pp. 995-1007.e18 [ Pubmed: 35303429 DOI: doi:10.1016/j.cell.2022.02.023 ]
- 1c3 heavy chain (13 kDa, Protein from Homo sapiens)
- Virion spike glycoprotein gp1 (31 kDa, Protein from Ebola virus - Gabon (1994-1997))
- Complex of ebov gp lacking the mucin-like-domain with 1c11 scfv and 1c3 fab (300 kDa, Complex from Homo sapiens)
- 1c11 scfv (26 kDa, Protein from Homo sapiens)
- 1c3 light chain (12 kDa, Protein from Homo sapiens)
- Virion spike glycoprotein gp2 (10 kDa, Protein from Zaire ebolavirus)
Structure of ZEBOV GP in complex with 1T0227 antibody
Resolution: 3.49 Å
EM Method: Single-particle
Fitted PDBs: 6s8d
Q-score: 0.476
Cohen-Dvashi H, Zehner M, Ehrhardt S, Katz M, Elad N, Klein F, Diskin R
Cell Host Microbe (2020) 27 pp. 418-427.e4 [ DOI: doi:10.1016/j.chom.2020.01.007 Pubmed: 32059794 ]
- Ebov-gp (Complex from Ebola virus)
- Light chain (23 kDa, Protein from Homo sapiens)
- 1t0227 antibody (Complex from Homo sapiens)
- Ebov-gp in complex with 1t0227 antibody (Complex)
- Envelope glycoprotein (18 kDa, Protein from Ebola virus)
- Envelope glycoprotein (35 kDa, Protein from Ebola virus)
- Heavy chain (24 kDa, Protein from Homo sapiens)
Structure of ZEBOV GP in complex with 3T0265 antibody
Resolution: 2.99 Å
EM Method: Single-particle
Fitted PDBs: 6s8i
Q-score: 0.517
Cohen-Dvashi H, Zehner M, Ehrhardt S, Katz M, Elad N, Klein F, Diskin R
Cell Host Microbe (2020) 27 pp. 418-427.e4 [ DOI: doi:10.1016/j.chom.2020.01.007 Pubmed: 32059794 ]
- Ebov-gp (Complex from Ebola virus)
- Ebov-gp in complex with 3t0265 antibody (Complex)
- 3t0265 antibody (Complex from Homo sapiens)
- Envelope glycoprotein (18 kDa, Protein from Ebola virus)
- Heavy chain (23 kDa, Protein from Homo sapiens)
- Enveloped glycoprotein 1 (35 kDa, Protein from Ebola virus)
- Light chain (23 kDa, Protein from Homo sapiens)
Structure of ZEBOV GP in complex with 5T0180 antibody
Resolution: 2.91 Å
EM Method: Single-particle
Fitted PDBs: 6s8j
Q-score: 0.554
Cohen-Dvashi H, Zehner M, Ehrhardt S, Katz M, Elad N, Klein F, Diskin R
Cell Host Microbe (2020) 27 pp. 418-427.e4 [ DOI: doi:10.1016/j.chom.2020.01.007 Pubmed: 32059794 ]
- Envelope glycoprotein 1 (35 kDa, Protein from Ebola virus)
- Ebov-gp (Complex from Ebola virus)
- Heavy chain (24 kDa, Protein from Homo sapiens)
- Ebov-gp in complex with 3t0265 antibody (Complex)
- Water (18 Da, Ligand)
- 5t0180 antibody (Complex from Homo sapiens)
- Envelope glycoprotein (18 kDa, Protein from Ebola virus)
- Light chain (23 kDa, Protein from Homo sapiens)
EM structure of a EBOV-GP bound to 3T0331 neutralizing antibody
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6qd7
Q-score: 0.386
Ehrhardt SA, Zehner M, Krahling V, Cohen-Dvashi H, Kreer C, Elad N, Gruell H, Ercanoglu MS, Schommers P, Gieselmann L, Eggeling R, Dahlke C, Wolf T, Pfeifer N, Addo MM, Diskin R, Becker S, Klein F
Nat Med (2019) 25 pp. 1589-1600 [ Pubmed: 31591605 DOI: doi:10.1038/s41591-019-0602-4 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ebov-gp (Complex from Ebola virus)
- Envelope glycoprotein,virion spike glycoprotein,ebov-gp1 (34 kDa, Protein from Ebola virus)
- Neutralizing 3t0331 antibody (Complex from Homo sapiens)
- Heavy chain (23 kDa, Protein from Homo sapiens)
- Light chain (23 kDa, Protein from Homo sapiens)
- Alpha-d-mannopyranose (180 Da, Ligand)
- Envelope glycoprotein (18 kDa, Protein from Ebola virus)
- Ebov-gp in complex with neutralizing 3t0331 antibody (Complex)
EM structure of a EBOV-GP bound to 4M0368 neutralizing antibody
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 6qd8
Q-score: 0.385
Diskin R, Cohen-Dvashi H, Ehrhardt S, Zehner M, Krahling V, Kreer C, Dahlke C, Ercanoglu MS, Gruell H, Addo MM, Becker S, Klein F
Nat Med (2019) [ ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ebov-gp (Complex from Ebola virus)
- Envelope glycoprotein,virion spike glycoprotein,ebov-gp1 (34 kDa, Protein from Ebola virus)
- Light chain (23 kDa, Protein from Homo sapiens)
- Neutralizing 3t0331 antibody (Complex from Homo sapiens)
- Envelope glycoprotein (18 kDa, Protein from Ebola virus)
- Ebov-gp in complex with neutralizing 3t0331 antibody (Complex)
- Heavy chain (23 kDa, Protein from Homo sapiens)
Structures of Protective Antibodies Reveal Sites of Vulnerability on Ebola Virus
Murin CD, Fusco ML, Bornholdt ZA, Qiu X, Olinger GG, Zeitlin L, Kobinger GP, Ward AB, Saphire EO
PNAS (2014) 111 pp. 17182-17187 [ DOI: doi:10.1073/pnas.1414164111 Pubmed: 25404321 ]
- Complex of ebola virus glycoprotein with transmembrane region and cytoplasmic tail removed (gpdtm) in complex with fab fragments of c1h3 chimerized human igg1 and human kz52 igg1 antibodies to ebola virus gp (750 kDa, Sample)
- Ebola virus gp (450 kDa, Protein from Ebola virus sp.)
- Chimerized human igg1 antigen binding fragment c1h3 (Protein from Homo sapiens)
- Chimerized human igg1 antigen binding fragment kz52 (Protein from Homo sapiens)