PRC2-AEBP2-JARID2 bound to H2AK119ub1 nucleosome
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6wkr
Q-score: 0.362
Kasinath V, Beck C, Sauer P, Poepsel S, Kosmatka J, Faini M, Toso D, Aebersold R, Nogales E
Science (2021) 371 [ Pubmed: 33479123 DOI: doi:10.1126/science.abc3393 ]
- Zinc finger protein aebp2 (33 kDa, Protein from Homo sapiens)
- Histone h2b 1.1 (13 kDa, Protein from Xenopus laevis)
- Ubiquitin (8 kDa, Protein from Homo sapiens)
- Histone-binding protein rbbp4 (47 kDa, Protein from Homo sapiens)
- Histone h4 (11 kDa, Protein from Xenopus laevis)
- Histone h2a type 1 (14 kDa, Protein from Xenopus laevis)
- Polycomb protein eed (50 kDa, Protein from Homo sapiens)
- Dna (314-mer) (98 kDa, DNA from Homo sapiens)
- Prc2-aebp2-jarid2 (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Histone-lysine n-methyltransferase ezh2 (85 kDa, Protein from Homo sapiens)
- Prc2-aebp2-jarid2 bound to h2ak119ub1 nucleosome (500 kDa, Complex)
- H2ak119ub1 nucleosome (Complex from Xenopus laevis)
- Zinc ion (65 Da, Ligand)
- Polycomb protein suz12 (83 kDa, Protein from Homo sapiens)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Histone h3.2 (15 kDa, Protein from Xenopus laevis)
- Protein jumonji (49 kDa, Protein from Homo sapiens)
Cryo-EM structure of PRC2 bound to cofactors AEBP2 and JARID2 in the Compact Active State
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6c23
Q-score: 0.394
Kasinath V, Faini M, Poepsel S, Reif D, Feng XA, Stjepanovic G, Aebersold R, Nogales E
Science (2018) 359 pp. 940-944 [ Pubmed: 29348366 DOI: doi:10.1126/science.aar5700 ]
- Histone-binding protein rbbp4 (47 kDa, Protein from Homo sapiens)
- Protein jumonji (37 kDa, Protein from Homo sapiens)
- Polycomb protein eed (50 kDa, Protein from Homo sapiens)
- Protein jumonji (37 kDa, Protein from Homo sapiens)
- Histone-lysine n-methyltransferase ezh2 (85 kDa, Protein from Homo sapiens)
- Jarid2-substrate (735 Da, Protein from Homo sapiens)
- Ternary complex of prc2 with cofactors aebp2 and jarid2 (300 kDa, Complex from Homo sapiens)
- Polycomb protein suz12 (83 kDa, Protein from Homo sapiens)
- Suz12 (11 kDa, Protein from Homo sapiens)
- Zinc finger protein aebp2 (33 kDa, Protein from Homo sapiens)
Cryo-EM structure of PRC2 bound to cofactors AEBP2 and JARID2 in the Extended Active State
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6c24
Q-score: 0.433
Kasinath V, Faini M, Poepsel S, Reif D, Feng XA, Stjepanovic G, Aebersold R, Nogales E
Science (2018) 359 pp. 940-944 [ Pubmed: 29348366 DOI: doi:10.1126/science.aar5700 ]
- Histone-binding protein rbbp4 (47 kDa, Protein from Homo sapiens)
- Polycomb protein eed (50 kDa, Protein from Homo sapiens)
- Protein jumonji (37 kDa, Protein from Homo sapiens)
- Histone-lysine n-methyltransferase ezh2 (85 kDa, Protein from Homo sapiens)
- Protein jumonji (37 kDa, Protein from Homo sapiens)
- Jarid2-substrate (735 Da, Protein from Homo sapiens)
- Ternary complex of prc2 with cofactors aebp2 and jarid2 (300 kDa, Complex from Homo sapiens)
- Polycomb protein suz12 (83 kDa, Protein from Homo sapiens)
- Suz12 (11 kDa, Protein from Homo sapiens)
- Zinc finger protein aebp2 (33 kDa, Protein from Homo sapiens)
Negative Staining Structure of Human Polycomb Repressive Complex 2 bound to the co-factor AEBP2
Ciferri C, Lander GC, Maiolica A, Herzog F, Aebersold R, Nogales E
eLife (2012) 1 pp. e00005-e00005 [ DOI: doi:10.7554/eLife.00005 Pubmed: 23110252 ]
- Suz12 (Protein from Homo sapiens)
- Aebp2 (Protein from Homo sapiens)
- Negative staining reconstruction of polycomb repressive complex 2 bound to the co-factor aebp2 (265 MDa, Sample)
- Ezh2 (Protein from Homo sapiens)
- Eed (Protein from Homo sapiens)
- Rbap48 (Protein from Homo sapiens)