PRC2_AJ1-450 bound to H3K36me3 with histone H3 tail engaged
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8vnv
Q-score: 0.357
Cookis T, Lydecker A, Sauer P, Kasinath V, Nogales E
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01452-x Pubmed: 39774834 ]
- Dna (26-mer) (7 kDa, DNA from Homo sapiens)
- H3k36me3-modified histone h3 (2 kDa, Protein from Homo sapiens)
- Polycomb protein suz12 (72 kDa, Protein from Homo sapiens)
- Prc2_aj1-450 bound to h3k36me3 modified nucleosome with tail engaged (Complex from Homo sapiens)
- Eed (50 kDa, Protein from Homo sapiens)
- Isoform 2 of histone-lysine n-methyltransferase ezh2 (85 kDa, Protein from Homo sapiens)
- Zinc finger protein aebp2 (31 kDa, Protein from Homo sapiens)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Dna (26-mer) (8 kDa, DNA from Homo sapiens)
- Rbap48 (47 kDa, Protein from Homo sapiens)
- Protein jumonji (49 kDa, Protein from Homo sapiens)
PRC2_AJ119-450 bound to H3K4me3
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8vmi
Q-score: 0.48
Cookis T, Lydecker A, Sauer P, Kasinath V, Nogales E
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01452-x Pubmed: 39774834 ]
- Ezh2 (85 kDa, Protein from Homo sapiens)
- Histone-binding protein rbbp4 (47 kDa, Protein from Homo sapiens)
- Histone h3.1 (747 Da, Protein from Homo sapiens)
- Polycomb protein eed (50 kDa, Protein from Homo sapiens)
- Prc2_aj119-450 bound to h3k4me3-modified nucleosome (350 kDa, Complex from Homo sapiens)
- Histone h3.1t (1 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Polycomb protein suz12 (83 kDa, Protein from Homo sapiens)
- Isoform 3 of zinc finger protein aebp2 (34 kDa, Protein from Homo sapiens)
- Protein jumonji (138 kDa, Protein from Homo sapiens)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8vml
Q-score: 0.366
Cookis T, Lydecker A, Sauer P, Kasinath V, Nogales E
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01452-x Pubmed: 39774834 ]
- Ezh2 (85 kDa, Protein from Homo sapiens)
- Prc2_aj1-450 bound to h3k4me3-modified nucleosome (350 kDa, Complex from Homo sapiens)
- Jarid2 (139 kDa, Protein from Homo sapiens)
- Eed (50 kDa, Protein from Homo sapiens)
- Aepb2 (34 kDa, Protein from Homo sapiens)
- Suz12 (83 kDa, Protein from Homo sapiens)
- Histone h3 (2 kDa, Protein from Homo sapiens)
- Rbap48 (47 kDa, Protein from Homo sapiens)
PRC2_AJ1-450 bound to H3K36me3-modified nucleosome with histone H3 tail disengaged
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8vnz
Q-score: 0.325
Cookis T, Lydecker A, Sauer P, Kasinath V, Nogales E
Nat Struct Mol Biol (2025) [ DOI: doi:10.1038/s41594-024-01452-x Pubmed: 39774834 ]
- Histone-lysine n-methyltransferase ezh2 (85 kDa, Protein from Homo sapiens)
- Histone-binding protein rbbp4 (47 kDa, Protein from Homo sapiens)
- Prc2_aj1-450 bound to h3k36me3-modified nucleosome (350 kDa, Complex from Homo sapiens)
- Polycomb protein eed (50 kDa, Protein from Homo sapiens)
- Polycomb protein suz12 (83 kDa, Protein from Homo sapiens)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Isoform 3 of zinc finger protein aebp2 (34 kDa, Protein from Homo sapiens)
- Protein jumonji (49 kDa, Protein from Homo sapiens)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8fyh
Q-score: 0.4
Song J, Gooding AR, Hemphill WO, Love BD, Robertson A, Yao L, Zon LI, North TE, Kasinath V, Cech TR
Science (2023) 381 pp. 1331-1337 [ Pubmed: 37733873 DOI: doi:10.1126/science.adh0059 ]
- Histone-binding protein rbbp4 (47 kDa, Protein from Homo sapiens)
- Zinc finger protein aebp2 (54 kDa, Protein from Homo sapiens)
- G4 rna (7 kDa, RNA from Homo sapiens)
- Polycomb protein eed (50 kDa, Protein from Homo sapiens)
- G4 rna-mediated dimer of polycomb repressive complex 2 (800 kDa, Complex from Homo sapiens)
- Histone-lysine n-methyltransferase ezh2 (86 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Polycomb protein suz12 (83 kDa, Protein from Homo sapiens)
- Protein jumonji isoform x3 (138 kDa, Protein from Homo sapiens)
Body1 of G4 RNA-mediated PRC2 dimer from multibody refinement
Song J, Gooding AR, Hemphill WO, Love BD, Robertson A, Yao L, Zon LI, North TE, Kasinath V, Cech TR
Science (2023) 381 pp. 1331-1337 [ Pubmed: 37733873 DOI: doi:10.1126/science.adh0059 ]
- Polycomb protein suz12 (Protein from Homo sapiens)
- Zinc finger protein aebp2 (Protein from Homo sapiens)
- Protein jumonji isoform x3 (Protein from Homo sapiens)
- Polycomb protein eed (Protein from Homo sapiens)
- G4 rna-mediated dimer of polycomb repressive complex 2 (Complex from Homo sapiens)
- G4 rna (RNA from Homo sapiens)
- Histone-binding protein rbbp4 (Protein from Homo sapiens)
- Histone-lysine n-methyltransferase ezh2 (Protein from Homo sapiens)
Body2 of G4 RNA-mediated PRC2 dimer from multibody refinement
Song J, Gooding AR, Hemphill WO, Love BD, Robertson A, Yao L, Zon LI, North TE, Kasinath V, Cech TR
Science (2023) 381 pp. 1331-1337 [ Pubmed: 37733873 DOI: doi:10.1126/science.adh0059 ]
- Polycomb protein suz12 (Protein from Homo sapiens)
- Zinc finger protein aebp2 (Protein from Homo sapiens)
- Protein jumonji isoform x3 (Protein from Homo sapiens)
- Polycomb protein eed (Protein from Homo sapiens)
- G4 rna-mediated dimer of polycomb repressive complex 2 (Complex from Homo sapiens)
- Histone-binding protein rbbp4 (Protein from Homo sapiens)
- Histone-lysine n-methyltransferase ezh2 (Protein from Homo sapiens)
PRC2-AEBP2-JARID2 bound to H2AK119ub1 nucleosome
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6wkr
Q-score: 0.362
Kasinath V, Beck C, Sauer P, Poepsel S, Kosmatka J, Faini M, Toso D, Aebersold R, Nogales E
Science (2021) 371 [ Pubmed: 33479123 DOI: doi:10.1126/science.abc3393 ]
- Zinc finger protein aebp2 (33 kDa, Protein from Homo sapiens)
- Histone h2b 1.1 (13 kDa, Protein from Xenopus laevis)
- Ubiquitin (8 kDa, Protein from Homo sapiens)
- Histone-binding protein rbbp4 (47 kDa, Protein from Homo sapiens)
- Histone h4 (11 kDa, Protein from Xenopus laevis)
- Histone h2a type 1 (14 kDa, Protein from Xenopus laevis)
- Polycomb protein eed (50 kDa, Protein from Homo sapiens)
- Dna (314-mer) (98 kDa, DNA from Homo sapiens)
- Prc2-aebp2-jarid2 (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Histone-lysine n-methyltransferase ezh2 (85 kDa, Protein from Homo sapiens)
- Prc2-aebp2-jarid2 bound to h2ak119ub1 nucleosome (500 kDa, Complex)
- H2ak119ub1 nucleosome (Complex from Xenopus laevis)
- Zinc ion (65 Da, Ligand)
- Polycomb protein suz12 (83 kDa, Protein from Homo sapiens)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Histone h3.2 (15 kDa, Protein from Xenopus laevis)
- Protein jumonji (49 kDa, Protein from Homo sapiens)
Cryo-EM structure of PRC2 bound to cofactors AEBP2 and JARID2 in the Compact Active State
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6c23
Q-score: 0.394
Kasinath V, Faini M, Poepsel S, Reif D, Feng XA, Stjepanovic G, Aebersold R, Nogales E
Science (2018) 359 pp. 940-944 [ Pubmed: 29348366 DOI: doi:10.1126/science.aar5700 ]
- Histone-binding protein rbbp4 (47 kDa, Protein from Homo sapiens)
- Protein jumonji (37 kDa, Protein from Homo sapiens)
- Polycomb protein eed (50 kDa, Protein from Homo sapiens)
- Protein jumonji (37 kDa, Protein from Homo sapiens)
- Histone-lysine n-methyltransferase ezh2 (85 kDa, Protein from Homo sapiens)
- Jarid2-substrate (735 Da, Protein from Homo sapiens)
- Ternary complex of prc2 with cofactors aebp2 and jarid2 (300 kDa, Complex from Homo sapiens)
- Polycomb protein suz12 (83 kDa, Protein from Homo sapiens)
- Suz12 (11 kDa, Protein from Homo sapiens)
- Zinc finger protein aebp2 (33 kDa, Protein from Homo sapiens)
Cryo-EM structure of PRC2 bound to cofactors AEBP2 and JARID2 in the Extended Active State
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6c24
Q-score: 0.433
Kasinath V, Faini M, Poepsel S, Reif D, Feng XA, Stjepanovic G, Aebersold R, Nogales E
Science (2018) 359 pp. 940-944 [ Pubmed: 29348366 DOI: doi:10.1126/science.aar5700 ]
- Histone-binding protein rbbp4 (47 kDa, Protein from Homo sapiens)
- Polycomb protein eed (50 kDa, Protein from Homo sapiens)
- Protein jumonji (37 kDa, Protein from Homo sapiens)
- Histone-lysine n-methyltransferase ezh2 (85 kDa, Protein from Homo sapiens)
- Protein jumonji (37 kDa, Protein from Homo sapiens)
- Jarid2-substrate (735 Da, Protein from Homo sapiens)
- Ternary complex of prc2 with cofactors aebp2 and jarid2 (300 kDa, Complex from Homo sapiens)
- Polycomb protein suz12 (83 kDa, Protein from Homo sapiens)
- Suz12 (11 kDa, Protein from Homo sapiens)
- Zinc finger protein aebp2 (33 kDa, Protein from Homo sapiens)