Automethylated PRC2 dimer bound to nucleosome
Resolution: 6.2 Å
EM Method: Single-particle
Fitted PDBs: 8t9g
Q-score: 0.163
Sauer PV, Pavlenko E, Cookis T, Zirden LC, Renn J, Singhal A, Hunold P, Hoehne-Wiechmann MN, van Ray O, Kaschani F, Kaiser M, Hansel-Hertsch R, Sanbonmatsu KY, Nogales E, Poepsel S
Mol Cell (2024) 84 pp. 3885-3898.e8 [ Pubmed: 39303719 DOI: doi:10.1016/j.molcel.2024.08.025 ]
- Proximal prc2 (Complex from Homo sapiens)
- Polycomb protein suz12 (72 kDa, Protein from Homo sapiens)
- Distal prc2 (Complex from Homo sapiens)
- Dna (226-mer) (65 kDa, DNA from synthetic construct)
- Histone-lysine n-methyltransferase ezh2 (86 kDa, Protein from Homo sapiens)
- Histone-binding protein rbbp4 (47 kDa, Protein from Homo sapiens)
- Zinc finger protein aebp2 (34 kDa, Protein from Homo sapiens)
- Activating methylated peptide (1 kDa, Protein from Homo sapiens)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Histone h4 (11 kDa, Protein from Xenopus laevis)
- Polycomb protein eed (50 kDa, Protein from Homo sapiens)
- Histone h2a type 1 (14 kDa, Protein from Xenopus laevis)
- Dna (226-mer) (66 kDa, DNA from synthetic construct)
- Histone h2b 1.1 (13 kDa, Protein from Xenopus laevis)
- Histone h3.2 (15 kDa, Protein from Xenopus laevis)
- Automethylated prc2 dimer bound to nucleosome (290 kDa, Complex from Homo sapiens)
- Nucleosome (Complex from Xenopus laevis)
PRC2 monomer bound to nucleosome
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 8tas
Q-score: 0.259
Sauer PV, Pavlenko E, Cookis T, Zirden LC, Renn J, Singhal A, Hunold P, Hoehne-Wiechmann MN, van Ray O, Kaschani F, Kaiser M, Hansel-Hertsch R, Sanbonmatsu KY, Nogales E, Poepsel S
Mol Cell (2024) 84 pp. 3885-3898.e8 [ Pubmed: 39303719 DOI: doi:10.1016/j.molcel.2024.08.025 ]
- Dna (226-mer) (65 kDa, DNA from synthetic construct)
- Polycomb protein suz12 (72 kDa, Protein from Homo sapiens)
- Histone-lysine n-methyltransferase ezh2 (86 kDa, Protein from Homo sapiens)
- Histone-binding protein rbbp4 (47 kDa, Protein from Homo sapiens)
- Zinc finger protein aebp2 (34 kDa, Protein from Homo sapiens)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Histone h4 (11 kDa, Protein from Xenopus laevis)
- Polycomb protein eed (50 kDa, Protein from Homo sapiens)
- Dna (226-mer) (66 kDa, DNA from synthetic construct)
- Histone h2a (14 kDa, Protein from Xenopus laevis)
- Histone h3.2 (15 kDa, Protein from Xenopus laevis)
- Nucleosome (Complex from Xenopus laevis)
- Histone h2b 1.1 (13 kDa, Protein from Xenopus laevis)
- Prc2 monomer bound to nucleosome (290 kDa, Complex from Homo sapiens)
- Prc2 (Complex from Homo sapiens)
PRC2-J119-450 monomer bound to H1-nucleosome
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8tb9
Q-score: 0.261
Sauer PV, Pavlenko E, Cookis T, Zirden LC, Renn J, Singhal A, Hunold P, Hoehne-Wiechmann MN, van Ray O, Kaschani F, Kaiser M, Hansel-Hertsch R, Sanbonmatsu KY, Nogales E, Poepsel S
Mol Cell (2024) 84 pp. 3885-3898.e8 [ Pubmed: 39303719 DOI: doi:10.1016/j.molcel.2024.08.025 ]
- Protein jumonji (36 kDa, Protein from Homo sapiens)
- Dna (226-mer) (65 kDa, DNA from synthetic construct)
- Polycomb protein suz12 (72 kDa, Protein from Homo sapiens)
- Histone h1.0 (21 kDa, Protein from Homo sapiens)
- Histone-lysine n-methyltransferase ezh2 (86 kDa, Protein from Homo sapiens)
- Histone-binding protein rbbp4 (47 kDa, Protein from Homo sapiens)
- Zinc finger protein aebp2 (34 kDa, Protein from Homo sapiens)
- Prc2-j119-450 monomer bound to h1-nucleosome (290 kDa, Complex from Homo sapiens)
- Prc2 (Complex from Homo sapiens)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Histone h4 (11 kDa, Protein from Xenopus laevis)
- Polycomb protein eed (50 kDa, Protein from Homo sapiens)
- Histone h2a type 1 (14 kDa, Protein from Xenopus laevis)
- Dna (226-mer) (66 kDa, DNA from synthetic construct)
- Histone h2b 1.1 (13 kDa, Protein from Xenopus laevis)
- Histone h3.2 (15 kDa, Protein from Xenopus laevis)
- Nucleosome (Complex from Xenopus laevis)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8fyh
Q-score: 0.4
Song J, Gooding AR, Hemphill WO, Love BD, Robertson A, Yao L, Zon LI, North TE, Kasinath V, Cech TR
Science (2023) 381 pp. 1331-1337 [ DOI: doi:10.1126/science.adh0059 Pubmed: 37733873 ]
- Zinc ion (65 Da, Ligand)
- G4 rna (7 kDa, RNA from Homo sapiens)
- Polycomb protein suz12 (83 kDa, Protein from Homo sapiens)
- G4 rna-mediated dimer of polycomb repressive complex 2 (800 kDa, Complex from Homo sapiens)
- Histone-binding protein rbbp4 (47 kDa, Protein from Homo sapiens)
- Protein jumonji isoform x3 (138 kDa, Protein from Homo sapiens)
- Polycomb protein eed (50 kDa, Protein from Homo sapiens)
- Zinc finger protein aebp2 (54 kDa, Protein from Homo sapiens)
- Histone-lysine n-methyltransferase ezh2 (86 kDa, Protein from Homo sapiens)
Body1 of G4 RNA-mediated PRC2 dimer from multibody refinement
Song J, Gooding AR, Hemphill WO, Love BD, Robertson A, Yao L, Zon LI, North TE, Kasinath V, Cech TR
Science (2023) 381 pp. 1331-1337 [ DOI: doi:10.1126/science.adh0059 Pubmed: 37733873 ]
- Histone-lysine n-methyltransferase ezh2 (Protein from Homo sapiens)
- G4 rna-mediated dimer of polycomb repressive complex 2 (Complex from Homo sapiens)
- Zinc finger protein aebp2 (Protein from Homo sapiens)
- Polycomb protein eed (Protein from Homo sapiens)
- Polycomb protein suz12 (Protein from Homo sapiens)
- G4 rna (RNA from Homo sapiens)
- Histone-binding protein rbbp4 (Protein from Homo sapiens)
- Protein jumonji isoform x3 (Protein from Homo sapiens)
Body2 of G4 RNA-mediated PRC2 dimer from multibody refinement
Song J, Gooding AR, Hemphill WO, Love BD, Robertson A, Yao L, Zon LI, North TE, Kasinath V, Cech TR
Science (2023) 381 pp. 1331-1337 [ DOI: doi:10.1126/science.adh0059 Pubmed: 37733873 ]
- Histone-lysine n-methyltransferase ezh2 (Protein from Homo sapiens)
- G4 rna-mediated dimer of polycomb repressive complex 2 (Complex from Homo sapiens)
- Zinc finger protein aebp2 (Protein from Homo sapiens)
- Polycomb protein eed (Protein from Homo sapiens)
- Polycomb protein suz12 (Protein from Homo sapiens)
- Histone-binding protein rbbp4 (Protein from Homo sapiens)
- Protein jumonji isoform x3 (Protein from Homo sapiens)
PRC2-AEBP2-JARID2 bound to H2AK119ub1 nucleosome
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6wkr
Q-score: 0.362
Kasinath V, Beck C, Sauer P, Poepsel S, Kosmatka J, Faini M, Toso D, Aebersold R, Nogales E
Science (2021) 371 [ DOI: doi:10.1126/science.abc3393 Pubmed: 33479123 ]
- Dna (314-mer) (98 kDa, DNA from Homo sapiens)
- Prc2-aebp2-jarid2 (Complex from Homo sapiens)
- Polycomb protein suz12 (83 kDa, Protein from Homo sapiens)
- Protein jumonji (49 kDa, Protein from Homo sapiens)
- Histone h3.2 (15 kDa, Protein from Xenopus laevis)
- Histone h2a type 1 (14 kDa, Protein from Xenopus laevis)
- Zinc ion (65 Da, Ligand)
- Histone-binding protein rbbp4 (47 kDa, Protein from Homo sapiens)
- H2ak119ub1 nucleosome (Complex from Xenopus laevis)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Prc2-aebp2-jarid2 bound to h2ak119ub1 nucleosome (500 kDa, Complex)
- Polycomb protein eed (50 kDa, Protein from Homo sapiens)
- Zinc finger protein aebp2 (33 kDa, Protein from Homo sapiens)
- Histone h4 (11 kDa, Protein from Xenopus laevis)
- Magnesium ion (24 Da, Ligand)
- Histone-lysine n-methyltransferase ezh2 (85 kDa, Protein from Homo sapiens)
- Ubiquitin (8 kDa, Protein from Homo sapiens)
- Histone h2b 1.1 (13 kDa, Protein from Xenopus laevis)
Cryo-EM structure of PRC2:EZH1-AEBP2-JARID2
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7kso
Q-score: 0.379
Grau D, Zhang Y, Lee CH, Valencia-Sanchez M, Zhang J, Wang M, Holder M, Svetlov V, Tan D, Nudler E, Reinberg D, Walz T, Armache KJ
Nat Commun (2021) 12 pp. 714-714 [ Pubmed: 33514705 DOI: doi:10.1038/s41467-020-20775-z ]
- Zinc ion (65 Da, Ligand)
- Polycomb protein suz12 (83 kDa, Protein from Homo sapiens)
- Zinc finger protein aebp2 (33 kDa, Protein from Homo sapiens)
- Protein jumonji (138 kDa, Protein from Homo sapiens)
- Histone-binding protein rbbp4 (47 kDa, Protein from Homo sapiens)
- Histone-lysine n-methyltransferase ezh1 (85 kDa, Protein from Homo sapiens)
- Polycomb protein eed (50 kDa, Protein from Homo sapiens)
- Prc2:ezh1-aebp2-jarid2 (330 kDa, Complex from Homo sapiens)
Cryo-EM map of PRC2:EZH1-AEBP2
Grau D, Zhang Y, Lee CH, Valencia-Sanchez M, Zhang J, Wang M, Holder M, Svetlov V, Tan D, Nudler E, Reinberg D, Walz T, Armache KJ
Nat Commun (2021) 12 pp. 714-714 [ Pubmed: 33514705 DOI: doi:10.1038/s41467-020-20775-z ]
- Suz12 (Protein from Homo sapiens)
- Aebp2 (Protein from Homo sapiens)
- Ezh1 (Protein from Homo sapiens)
- Prc2:ezh1-aebp2 (299 kDa, Complex from Homo sapiens)
- Rbap48 (Protein from Homo sapiens)
- Eed (Protein from Homo sapiens)
PRC2:EZH1_A from a dimeric PRC2 bound to a nucleosome
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7ksr
Q-score: 0.287
Grau D, Zhang Y, Lee CH, Valencia-Sanchez M, Zhang J, Wang M, Holder M, Svetlov V, Tan D, Nudler E, Reinberg D, Walz T, Armache KJ
Nat Commun (2021) 12 pp. 714-714 [ Pubmed: 33514705 DOI: doi:10.1038/s41467-020-20775-z ]
- Zinc ion (65 Da, Ligand)
- Polycomb protein suz12 (83 kDa, Protein from Homo sapiens)
- Histone-binding protein rbbp4 (47 kDa, Protein from Homo sapiens)
- Histone-lysine n-methyltransferase ezh1 (85 kDa, Protein from Homo sapiens)
- Polycomb protein eed (50 kDa, Protein from Homo sapiens)
- Prc2:ezh1_a from a prc2:ezh1 dimer bound to a nucleosome (266 kDa, Complex from Homo sapiens)