PRC2_AJ1-450 bound to H3K36me3 with histone H3 tail engaged
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8vnv
Q-score: 0.357
Cookis T, Lydecker A, Sauer P, Kasinath V, Nogales E
Nat Struct Mol Biol (2025) [ Pubmed: 39774834 DOI: doi:10.1038/s41594-024-01452-x ]
- Prc2_aj1-450 bound to h3k36me3 modified nucleosome with tail engaged (Complex from Homo sapiens)
- Isoform 2 of histone-lysine n-methyltransferase ezh2 (85 kDa, Protein from Homo sapiens)
- Protein jumonji (49 kDa, Protein from Homo sapiens)
- Zinc finger protein aebp2 (31 kDa, Protein from Homo sapiens)
- Eed (50 kDa, Protein from Homo sapiens)
- Dna (26-mer) (8 kDa, DNA from Homo sapiens)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Polycomb protein suz12 (72 kDa, Protein from Homo sapiens)
- Rbap48 (47 kDa, Protein from Homo sapiens)
- Dna (26-mer) (7 kDa, DNA from Homo sapiens)
- H3k36me3-modified histone h3 (2 kDa, Protein from Homo sapiens)
PRC2_AJ119-450 bound to H3K4me3
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8vmi
Q-score: 0.48
Cookis T, Lydecker A, Sauer P, Kasinath V, Nogales E
Nat Struct Mol Biol (2025) [ Pubmed: 39774834 DOI: doi:10.1038/s41594-024-01452-x ]
- Zinc ion (65 Da, Ligand)
- Histone h3.1 (747 Da, Protein from Homo sapiens)
- Polycomb protein suz12 (83 kDa, Protein from Homo sapiens)
- Protein jumonji (138 kDa, Protein from Homo sapiens)
- Histone h3.1t (1 kDa, Protein from Homo sapiens)
- Histone-binding protein rbbp4 (47 kDa, Protein from Homo sapiens)
- Ezh2 (85 kDa, Protein from Homo sapiens)
- Isoform 3 of zinc finger protein aebp2 (34 kDa, Protein from Homo sapiens)
- Polycomb protein eed (50 kDa, Protein from Homo sapiens)
- Prc2_aj119-450 bound to h3k4me3-modified nucleosome (350 kDa, Complex from Homo sapiens)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8vml
Q-score: 0.366
Cookis T, Lydecker A, Sauer P, Kasinath V, Nogales E
Nat Struct Mol Biol (2025) [ Pubmed: 39774834 DOI: doi:10.1038/s41594-024-01452-x ]
- Histone h3 (2 kDa, Protein from Homo sapiens)
- Aepb2 (34 kDa, Protein from Homo sapiens)
- Ezh2 (85 kDa, Protein from Homo sapiens)
- Suz12 (83 kDa, Protein from Homo sapiens)
- Eed (50 kDa, Protein from Homo sapiens)
- Prc2_aj1-450 bound to h3k4me3-modified nucleosome (350 kDa, Complex from Homo sapiens)
- Rbap48 (47 kDa, Protein from Homo sapiens)
- Jarid2 (139 kDa, Protein from Homo sapiens)
PRC2_AJ1-450 bound to H3K36me3-modified nucleosome with histone H3 tail disengaged
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8vnz
Q-score: 0.325
Cookis T, Lydecker A, Sauer P, Kasinath V, Nogales E
Nat Struct Mol Biol (2025) [ Pubmed: 39774834 DOI: doi:10.1038/s41594-024-01452-x ]
- Protein jumonji (49 kDa, Protein from Homo sapiens)
- Polycomb protein suz12 (83 kDa, Protein from Homo sapiens)
- Histone-binding protein rbbp4 (47 kDa, Protein from Homo sapiens)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Isoform 3 of zinc finger protein aebp2 (34 kDa, Protein from Homo sapiens)
- Polycomb protein eed (50 kDa, Protein from Homo sapiens)
- Prc2_aj1-450 bound to h3k36me3-modified nucleosome (350 kDa, Complex from Homo sapiens)
- Histone-lysine n-methyltransferase ezh2 (85 kDa, Protein from Homo sapiens)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8fyh
Q-score: 0.4
Song J, Gooding AR, Hemphill WO, Love BD, Robertson A, Yao L, Zon LI, North TE, Kasinath V, Cech TR
Science (2023) 381 pp. 1331-1337 [ DOI: doi:10.1126/science.adh0059 Pubmed: 37733873 ]
- Zinc ion (65 Da, Ligand)
- G4 rna (7 kDa, RNA from Homo sapiens)
- Polycomb protein suz12 (83 kDa, Protein from Homo sapiens)
- G4 rna-mediated dimer of polycomb repressive complex 2 (800 kDa, Complex from Homo sapiens)
- Histone-binding protein rbbp4 (47 kDa, Protein from Homo sapiens)
- Protein jumonji isoform x3 (138 kDa, Protein from Homo sapiens)
- Polycomb protein eed (50 kDa, Protein from Homo sapiens)
- Zinc finger protein aebp2 (54 kDa, Protein from Homo sapiens)
- Histone-lysine n-methyltransferase ezh2 (86 kDa, Protein from Homo sapiens)
Body1 of G4 RNA-mediated PRC2 dimer from multibody refinement
Song J, Gooding AR, Hemphill WO, Love BD, Robertson A, Yao L, Zon LI, North TE, Kasinath V, Cech TR
Science (2023) 381 pp. 1331-1337 [ DOI: doi:10.1126/science.adh0059 Pubmed: 37733873 ]
- Histone-lysine n-methyltransferase ezh2 (Protein from Homo sapiens)
- G4 rna-mediated dimer of polycomb repressive complex 2 (Complex from Homo sapiens)
- Zinc finger protein aebp2 (Protein from Homo sapiens)
- Polycomb protein eed (Protein from Homo sapiens)
- Polycomb protein suz12 (Protein from Homo sapiens)
- G4 rna (RNA from Homo sapiens)
- Histone-binding protein rbbp4 (Protein from Homo sapiens)
- Protein jumonji isoform x3 (Protein from Homo sapiens)
Body2 of G4 RNA-mediated PRC2 dimer from multibody refinement
Song J, Gooding AR, Hemphill WO, Love BD, Robertson A, Yao L, Zon LI, North TE, Kasinath V, Cech TR
Science (2023) 381 pp. 1331-1337 [ DOI: doi:10.1126/science.adh0059 Pubmed: 37733873 ]
- Histone-lysine n-methyltransferase ezh2 (Protein from Homo sapiens)
- G4 rna-mediated dimer of polycomb repressive complex 2 (Complex from Homo sapiens)
- Zinc finger protein aebp2 (Protein from Homo sapiens)
- Polycomb protein eed (Protein from Homo sapiens)
- Polycomb protein suz12 (Protein from Homo sapiens)
- Histone-binding protein rbbp4 (Protein from Homo sapiens)
- Protein jumonji isoform x3 (Protein from Homo sapiens)
PRC2-AEBP2-JARID2 bound to H2AK119ub1 nucleosome
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6wkr
Q-score: 0.362
Kasinath V, Beck C, Sauer P, Poepsel S, Kosmatka J, Faini M, Toso D, Aebersold R, Nogales E
Science (2021) 371 [ DOI: doi:10.1126/science.abc3393 Pubmed: 33479123 ]
- Dna (314-mer) (98 kDa, DNA from Homo sapiens)
- Prc2-aebp2-jarid2 (Complex from Homo sapiens)
- Polycomb protein suz12 (83 kDa, Protein from Homo sapiens)
- Protein jumonji (49 kDa, Protein from Homo sapiens)
- Histone h3.2 (15 kDa, Protein from Xenopus laevis)
- Histone h2a type 1 (14 kDa, Protein from Xenopus laevis)
- Zinc ion (65 Da, Ligand)
- Histone-binding protein rbbp4 (47 kDa, Protein from Homo sapiens)
- H2ak119ub1 nucleosome (Complex from Xenopus laevis)
- S-adenosyl-l-homocysteine (384 Da, Ligand)
- Prc2-aebp2-jarid2 bound to h2ak119ub1 nucleosome (500 kDa, Complex)
- Polycomb protein eed (50 kDa, Protein from Homo sapiens)
- Zinc finger protein aebp2 (33 kDa, Protein from Homo sapiens)
- Histone h4 (11 kDa, Protein from Xenopus laevis)
- Magnesium ion (24 Da, Ligand)
- Histone-lysine n-methyltransferase ezh2 (85 kDa, Protein from Homo sapiens)
- Ubiquitin (8 kDa, Protein from Homo sapiens)
- Histone h2b 1.1 (13 kDa, Protein from Xenopus laevis)
Cryo-EM structure of PRC2:EZH1-AEBP2-JARID2
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7kso
Q-score: 0.379
Grau D, Zhang Y, Lee CH, Valencia-Sanchez M, Zhang J, Wang M, Holder M, Svetlov V, Tan D, Nudler E, Reinberg D, Walz T, Armache KJ
Nat Commun (2021) 12 pp. 714-714 [ Pubmed: 33514705 DOI: doi:10.1038/s41467-020-20775-z ]
- Zinc ion (65 Da, Ligand)
- Polycomb protein suz12 (83 kDa, Protein from Homo sapiens)
- Zinc finger protein aebp2 (33 kDa, Protein from Homo sapiens)
- Protein jumonji (138 kDa, Protein from Homo sapiens)
- Histone-binding protein rbbp4 (47 kDa, Protein from Homo sapiens)
- Histone-lysine n-methyltransferase ezh1 (85 kDa, Protein from Homo sapiens)
- Polycomb protein eed (50 kDa, Protein from Homo sapiens)
- Prc2:ezh1-aebp2-jarid2 (330 kDa, Complex from Homo sapiens)
Cryo-EM map of PRC2:EZH1-AEBP2
Grau D, Zhang Y, Lee CH, Valencia-Sanchez M, Zhang J, Wang M, Holder M, Svetlov V, Tan D, Nudler E, Reinberg D, Walz T, Armache KJ
Nat Commun (2021) 12 pp. 714-714 [ Pubmed: 33514705 DOI: doi:10.1038/s41467-020-20775-z ]
- Suz12 (Protein from Homo sapiens)
- Aebp2 (Protein from Homo sapiens)
- Ezh1 (Protein from Homo sapiens)
- Prc2:ezh1-aebp2 (299 kDa, Complex from Homo sapiens)
- Rbap48 (Protein from Homo sapiens)
- Eed (Protein from Homo sapiens)