Structure of the human BOS:human EMC complex in GDN
Resolution: 6.6 Å
EM Method: Single-particle
Fitted PDBs: 9c7v
Q-score: 0.166
Page KR, Nguyen VN, Pleiner T, Tomaleri GP, Wang ML, Guna A, Hazu M, Wang TY, Chou TF, Voorhees RM
Mol Cell (2024) 84 pp. 3302- [ DOI: doi:10.1016/j.molcel.2024.08.005 Pubmed: 39173640 ]
- Transmembrane protein 147 (25 kDa, Protein from Homo sapiens)
- Membrane magnesium transporter 1 (14 kDa, Protein from Homo sapiens)
- Nicalin (63 kDa, Protein from Homo sapiens)
- Human bos complex (Complex from Homo sapiens)
- Er membrane protein complex subunit 1 (111 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 4 (20 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 10 (27 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 8 (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Er membrane protein complex subunit 6 (12 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 7 (26 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 3 (29 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 2 (34 kDa, Protein from Homo sapiens)
- Bos complex subunit nomo2 (139 kDa, Protein from Homo sapiens)
cryo-EM structure of human EMC
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 8j0n
Q-score: 0.031
Li M, Zhang C, Xu Y, Li S, Huang C, Wu J, Lei M
Aging (Albany NY) (2024) 16 pp. 5501-5525 [ Pubmed: 38517390 DOI: doi:10.18632/aging.205660 ]
- Emc (Complex from Homo sapiens)
- Er membrane protein complex subunit 10 (21 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 1 (111 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 4 (20 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 8 (23 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 6 (12 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 5 (14 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 7 (26 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 3 (29 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 2 (34 kDa, Protein from Homo sapiens)
cryo-EM structure of human EMC and VDAC
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 8j0o
Q-score: 0.017
Li M, Zhang C, Xu Y, Li S, Huang C, Wu J, Lei M
Aging (Albany NY) (2024) 16 pp. 5501-5525 [ DOI: doi:10.18632/aging.205660 Pubmed: 38517390 ]
- Er membrane protein complex subunit 10 (21 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 3 (29 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 6 (12 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 1 (111 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 8 (23 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 4 (20 kDa, Protein from Homo sapiens)
- Emc_vdac (Complex from Homo sapiens)
- Er membrane protein complex subunit 5 (14 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 7 (26 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 2 (34 kDa, Protein from Homo sapiens)
- Voltage-dependent anion-selective channel protein 1 (30 kDa, Protein from Homo sapiens)
Structure of a human EMC:human Cav1.2 channel complex in GDN detergent (ECAB Map 3)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8eoi
Q-score: 0.411
Chen Z, Mondal A, Abderemane-Ali F, Jang S, Niranjan S, Montano JL, Zaro BW, Minor Jr DL
Nature (2023) 619 pp. 410-419 [ DOI: doi:10.1038/s41586-023-06175-5 Pubmed: 37196677 ]
- Er membrane protein complex subunit 1 (109 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 3 (29 kDa, Protein from Homo sapiens)
- Human cav alpha1c (187 kDa, Complex from Homo sapiens)
- Rabbit cav beta3 (100 kDa, Complex from Oryctolagus cuniculus)
- Er membrane protein complex subunit 8 (23 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 1 (112 kDa, Complex from Homo sapiens)
- Er membrane protein complex subunit 10 (17 kDa, Protein from Homo sapiens)
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit alpha-1c (176 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 5 (11 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 6 (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Er membrane protein complex subunit 4 (18 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 2 (34 kDa, Protein from Homo sapiens)
- Ternary complex of the human er membrane protein complex (emc) with human cav alpha1c and rabbit cav beta3 (Complex from Homo sapiens)
- Er membrane protein complex subunit 7 (13 kDa, Protein from Homo sapiens)
- Voltage-dependent l-type calcium channel subunit beta-3 (36 kDa, Protein from Oryctolagus cuniculus)
Human ER membrane protein complex (EMC) in GDN, 9-subunit map
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8s9s
Q-score: 0.404
Pleiner T, Hazu M, Pinton Tomaleri G, Nguyen VN, Januszyk K, Voorhees RM
J Cell Biol (2023) 222 [ Pubmed: 37199759 DOI: doi:10.1083/jcb.202212007 ]
- Human er membrane protein complex (Complex from Homo sapiens)
- Membrane magnesium transporter 1 (14 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 1 (111 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 4 (20 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 8 (23 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 10 (27 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Er membrane protein complex subunit 6 (12 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 7 (26 kDa, Protein from Homo sapiens)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Er membrane protein complex subunit 3 (29 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 2 (34 kDa, Protein from Homo sapiens)
Human ER membrane protein complex (EMC) in GDN, Consensus map
Pleiner T, Hazu M, Pinton Tomaleri G, Nguyen VN, Januszyk K, Voorhees RM
J Cell Biol (2023) 222 [ Pubmed: 37199759 DOI: doi:10.1083/jcb.202212007 ]
- Er membrane protein complex subunit 6 (Protein from Homo sapiens)
- Er membrane protein complex subunit 8 (Protein from Homo sapiens)
- Human er membrane protein complex (Complex from Homo sapiens)
- Er membrane protein complex subunit 7 (Protein from Homo sapiens)
- Er membrane protein complex subunit 10 (Protein from Homo sapiens)
- Er membrane protein complex subunit 2 (Protein from Homo sapiens)
- Er membrane protein complex subunit 3 (Protein from Homo sapiens)
- Er membrane protein complex subunit 5 (Protein from Homo sapiens)
- Er membrane protein complex subunit 4 (Protein from Homo sapiens)
- Er membrane protein complex subunit 1 (Protein from Homo sapiens)
Human ER membrane protein complex (EMC) in GDN, 8-subunit map
Pleiner T, Hazu M, Pinton Tomaleri G, Nguyen VN, Januszyk K, Voorhees RM
J Cell Biol (2023) 222 [ Pubmed: 37199759 DOI: doi:10.1083/jcb.202212007 ]
- Human er membrane protein complex (Complex from Homo sapiens)
- Er membrane protein complex subunit 4 (Protein)
- Er membrane protein complex subunit 2 (Protein)
- Er membrane protein complex subunit 3 (Protein)
- Er membrane protein complex subunit 5 (Protein)
- Er membrane protein complex subunit 1 (Protein)
- Er membrane protein complex subunit 8 (Protein)
- Er membrane protein complex subunit 7 (Protein)
- Er membrane protein complex subunit 6 (Protein)
Cryo-EM structure of human ER membrane protein complex in lipid nanodiscs
Resolution: 3.39 Å
EM Method: Single-particle
Fitted PDBs: 7ado
Q-score: 0.458
Miller-Vedam LE, Brauning B, Popova KD, Schirle Oakdale NT, Bonnar JL, Prabu JR, Boydston EA, Sevillano N, Shurtleff MJ, Stroud RM, Craik CS, Schulman BA, Frost A, Weissman JS
eLife (2020) 9 [ Pubmed: 33236988 DOI: doi:10.7554/eLife.62611 ]
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Er membrane protein complex subunit 3 (29 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 6 (12 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 1 (111 kDa, Protein from Homo sapiens)
- Human endoplasmic reticulum membrane protein complex (emc) in popc nanodiscs (300 kDa, Complex from Homo sapiens)
- Er membrane protein complex subunit 8 (23 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 4 (20 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 10 (27 kDa, Protein from Homo sapiens)
- Unassigned helix (1 kDa, Protein from Homo sapiens)
- Membrane magnesium transporter 1 (15 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 7 (26 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 2 (34 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of human ER membrane protein complex in GDN detergent
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7adp
Q-score: 0.43
Miller-Vedam LE, Brauning B, Popova KD, Schirle Oakdale NT, Bonnar JL, Prabu JR, Boydston EA, Sevillano N, Shurtleff MJ, Stroud RM, Craik CS, Schulman BA, Frost A, Weissman JS
eLife (2020) 9 [ Pubmed: 33236988 DOI: doi:10.7554/eLife.62611 ]
- Human endoplasmic reticulum membrane protein complex (emc) in popc nanodiscs (300 kDa, Complex from Homo sapiens)
- Membrane magnesium transporter 1 (15 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 10 (27 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 1 (111 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 4 (20 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 8 (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Er membrane protein complex subunit 6 (12 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 3 (29 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 2 (34 kDa, Protein from Homo sapiens)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7kra
Q-score: 0.474
Miller-Vedam LE, Brauning B, Popova KD, Schirle Oakdale NT, Bonnar JL, Prabu JR, Boydston EA, Sevillano N, Shurtleff MJ, Stroud RM, Craik CS, Schulman BA, Frost A, Weissman JS
eLife (2020) 9 [ Pubmed: 33236988 DOI: doi:10.7554/eLife.62611 ]
- Endoplasmic reticulum membrane protein complex (Complex from Saccharomyces cerevisiae)
- Er membrane protein complex subunit 4 (21 kDa, Protein from Saccharomyces cerevisiae)
- Er membrane protein complex subunit 3 (28 kDa, Protein from Saccharomyces cerevisiae)
- Protein sop4 (26 kDa, Protein from Saccharomyces cerevisiae)
- Fab dh4 light chain (25 kDa, Protein from Homo sapiens)
- S. cerevisiae endoplasmic reticulum membrane protein complex (emc) bound to fab dh4 in yeast total extract lipid nanodiscs (Complex)
- [(2~{r})-1-octanoyloxy-3-[oxidanyl-[2-(trimethyl-$l^{4}-azanyl)ethoxy]phosphoryl]oxy-propan-2-yl] nonanoate (524 Da, Ligand)
- Er membrane protein complex subunit 1 (87 kDa, Protein from Saccharomyces cerevisiae)
- Endoplasmic reticulum membrane protein complex subunit 10 (22 kDa, Protein from Saccharomyces cerevisiae)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Unassigned helix (2 kDa, Protein from Saccharomyces cerevisiae)
- Er membrane protein complex subunit 2 (33 kDa, Protein from Saccharomyces cerevisiae)
- Fab dh4 heavy chain (26 kDa, Protein from Homo sapiens)
- Er membrane protein complex subunit 6 (12 kDa, Protein from Saccharomyces cerevisiae)
- Er membrane protein complex subunit 5 (20 kDa, Protein from Saccharomyces cerevisiae)
- Fab dh4 (Complex from Homo sapiens)