Cryo-EM structure of a trapped ARIH1-diUB-CRL2-KLHDC10 complex - consensus map
Scott DC, Chittori S, Purser N, King MT, Maiwald SA, Churion K, Nourse A, Lee C, Paulo JA, Miller DJ, Elledge SJ, Harper JW, Kleiger G, Schulman BA
Nat Commun (2024) 15 pp. 9899-9899 [ DOI: doi:10.1038/s41467-024-54126-z Pubmed: 39548056 ]
- Klhdc10 (Protein from Homo sapiens)
- Elob (Protein from Homo sapiens)
- Cul2 (Protein from Homo sapiens)
- Nedd8 (Protein from Homo sapiens)
- Ub (Protein from Homo sapiens)
- Trapped arih1-diub-crl2-klhdc10 complex (270 kDa, Complex)
- Arih1 (Protein from Homo sapiens)
- Eloc (Protein from Homo sapiens)
- Rbx1 (Protein from Homo sapiens)
The cryo-EM structure of PPP2R5A/HIV-1 Vif/CBFb/EloB/EloC complex
Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 8szk
Q-score: 0.327
Hu Y, Delviks-Frankenberry KA, Wu C, Arizaga F, Pathak VK, Xiong Y
Nat Struct Mol Biol (2024) 31 pp. 1492-1501 [ Pubmed: 38789685 DOI: doi:10.1038/s41594-024-01314-6 ]
- Ppp2r5a in complex with hiv-1 vif/cbfb/elob/eloc (Complex from Homo sapiens)
- Virion infectivity factor (20 kDa, Protein from Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE))
- Serine/threonine-protein phosphatase 2a 56 kda regulatory subunit alpha isoform (56 kDa, Protein from Homo sapiens)
- Core-binding factor subunit beta (23 kDa, Protein from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Elongin-c (10 kDa, Protein from Homo sapiens)
KLHDC2 in complex with EloB and EloC
Resolution: 3.74 Å
EM Method: Single-particle
Fitted PDBs: 8sh2
Q-score: 0.195
Hickey CM, Digianantonio KM, Zimmermann K, Harbin A, Quinn C, Patel A, Gareiss P, Chapman A, Tiberi B, Dobrodziej J, Corradi J, Cacace AM, Langley DR, Bekes M
Nat Struct Mol Biol (2024) 31 pp. 311-322 [ DOI: doi:10.1038/s41594-023-01146-w Pubmed: 38177675 ]
- Kelch domain-containing protein 2 (46 kDa, Protein from Homo sapiens)
- Elongin-b (11 kDa, Protein from Homo sapiens)
- Elongin-c (10 kDa, Protein from Homo sapiens)
- Full-length klhdc2 in complex with elob and eloc (Complex from Homo sapiens)
PROTAC-mediated complex of KRAS with VHL/Elongin-B/Elongin-C/Cullin-2/Rbx1
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8qu8
Q-score: 0.306
Popow J, Farnaby W, Gollner A, Kofink C, Fischer G, Wurm M, Zollman D, Wijaya A, Mischerikow N, Hasenoehrl C, Prokofeva P, Arnhof H, Arce-Solano S, Bell S, Boeck G, Diers E, Frost AB, Goodwin-Tindall J, Karolyi-Oezguer J, Khan S, Klawatsch T, Koegl M, Kousek R, Kratochvil B, Kropatsch K, Lauber AA, McLennan R, Olt S, Peter D, Petermann O, Roessler V, Stolt-Bergner P, Strack P, Strauss E, Trainor N, Vetma V, Whitworth C, Zhong S, Quant J, Weinstabl H, Kuster B, Ettmayer P, Ciulli A
Science (2024) 385 pp. 1338-1347 [ DOI: doi:10.1126/science.adm8684 Pubmed: 39298590 ]
- Zinc ion (65 Da, Ligand)
- Gtpase kras (19 kDa, Protein from Homo sapiens)
- (2s,4r)-1-[(2s)-2-[4-[4-[(3s)-4-[4-[5-[(4s)-2-azanyl-3-cyano-4-methyl-6,7-dihydro-5h-1-benzothiophen-4-yl]-1,2,4-oxadiazol-3-yl]pyrimidin-2-yl]-3-methyl-1,4-diazepan-1-yl]butoxy]-1,2,3-triazol-1-yl]-3-methyl-butanoyl]-n-[(1r)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]-2-oxidanyl-ethyl]-4-oxidanyl-pyrrolidine-2-carboxamide (1 kDa, Ligand)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Kras/acbi3/vhl/elob/eloc/cul2/rbx1 (168 kDa, Complex from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Elongin-c (12 kDa, Protein from Homo sapiens)
- Cullin-2 (86 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1, n-terminally processed (12 kDa, Protein from Homo sapiens)
- Von hippel-lindau disease tumor suppressor (24 kDa, Protein from Homo sapiens)