Cryo-EM structure of enterovirus A71 mature virion in complex with Fab h1A6.2
Zhu R, Wu Y, Huang Y, Jiang Y, Jiang Y, Zhang D, Sun H, Zhou Z, Zhou L, Weng S, Chen H, Chen X, Ning W, Zou Y, He M, Yang H, Deng W, Li Y, Chen Z, Ye X, Han J, Yin Z, Zhao H, Liu C, Que Y, Fang M, Yu H, Zhang J, Luo W, Li S, Zheng Q, Xu L, Xia N, Cheng T
Nat Microbiol (2024) 9 pp. 2939-2953 [ DOI: doi:10.1038/s41564-024-01822-7 Pubmed: 39424982 ]
- Fab h1a6.2 (Complex from Mus)
- Capsid protein vp3 (26 kDa, Protein from Enterovirus A71)
- Capsid protein vp4 (7 kDa, Protein from Enterovirus A71)
- Enterovirus a71 mature virion in complex with fab h1a6.2 (Complex)
- Sphingosine (299 Da, Ligand)
- Capsid protein vp2 (27 kDa, Protein from Enterovirus A71)
- Enterovirus a71 (Virus from Enterovirus A71)
- Capsid protein vp1 (32 kDa, Protein from Enterovirus A71)
Cryo-EM structure of enterovirus A71 mature virion
Zhu R, Wu Y, Huang Y, Jiang Y, Jiang Y, Zhang D, Sun H, Zhou Z, Zhou L, Weng S, Chen H, Chen X, Ning W, Zou Y, He M, Yang H, Deng W, Li Y, Chen Z, Ye X, Han J, Yin Z, Zhao H, Liu C, Que Y, Fang M, Yu H, Zhang J, Luo W, Li S, Zheng Q, Xu L, Xia N, Cheng T
Nat Microbiol (2024) 9 pp. 2939-2953 [ DOI: doi:10.1038/s41564-024-01822-7 Pubmed: 39424982 ]
- Capsid protein vp3 (26 kDa, Protein from Enterovirus A71)
- Capsid protein vp4 (7 kDa, Protein from Enterovirus A71)
- Sphingosine (299 Da, Ligand)
- Capsid protein vp2 (27 kDa, Protein from Enterovirus A71)
- Enterovirus a71 (Virus from Enterovirus A71)
- Capsid protein vp1 (32 kDa, Protein from Enterovirus A71)
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 9f5s
Q-score: 0.638
Kingston NJ, Snowden JS, Grehan K, Hall PK, Hietanen EV, Passchier TC, Polyak SJ, Filman DJ, Hogle JM, Rowlands DJ, Stonehouse NJ
PLoS Pathog (2024) 20 pp. e1012511-e1012511 [ Pubmed: 39298524 DOI: doi:10.1371/journal.ppat.1012511 ]
- Vp0 (35 kDa, Protein from Enterovirus A71)
- Vp3 (26 kDa, Protein from Enterovirus A71)
- Sphingosine (299 Da, Ligand)
- Vp1 (32 kDa, Protein from Enterovirus A71)
- Enterovirus a71 (Virus from Enterovirus A71)
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 9f6a
Q-score: 0.61
Kingston NJ, Snowden JS, Grehan K, Hall PK, Hietanen EV, Passchier TC, Polyak SJ, Filman DJ, Hogle JM, Rowlands DJ, Stonehouse NJ
PLoS Pathog (2024) 20 pp. e1012511-e1012511 [ Pubmed: 39298524 DOI: doi:10.1371/journal.ppat.1012511 ]
- Sphingosine (299 Da, Ligand)
- Vp0 (35 kDa, Protein from Enterovirus A71)
- Vp1 (32 kDa, Protein from Enterovirus A71)
- Vp3 (26 kDa, Protein from Enterovirus A71)
- Enterovirus a71 (Virus from Enterovirus A71)
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 8c6d
Q-score: 0.614
Kingston NJ, Snowden JS, Martyna A, Shegdar M, Grehan K, Tedcastle A, Pegg E, Fox H, Macadam AJ, Martin J, Hogle JM, Rowlands DJ, Stonehouse NJ
bioRxiv (2023) [ Pubmed: 36778240 DOI: doi:10.1101/2023.01.30.526315 ]
- (2s,3r,4e)-2-aminooctadec-4-ene-1,3-diol (299 Da, Ligand)
- Genome polyprotein (fragment) (35 kDa, Protein from Enterovirus A71)
- Genome polyprotein (26 kDa, Protein from Enterovirus A71)
- Genome polyprotein (32 kDa, Protein from Enterovirus A71)
- Enterovirus a71 (Virus from Enterovirus A71)
Structure of EV71 in complex with a protective antibody 38-3-11A Fab
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 6z3p
Q-score: 0.623
Huang KA, Zhou D, Fry EE, Kotecha A, Huang PN, Yang SL, Tsao KC, Huang YC, Lin TY, Ren J, Stuart DI
Nat Commun (2020) 11 pp. 5253-5253 [ Pubmed: 33067459 DOI: doi:10.1038/s41467-020-19013-3 ]
- Protective antibody 38-3-11a fab (Complex from Homo sapiens)
- Vp2 (27 kDa, Protein from Enterovirus A71)
- Enterovirus a71 (Complex from Enterovirus A71)
- Vp3 (26 kDa, Protein from Enterovirus A71)
- Vp4 (6 kDa, Protein from Enterovirus A71)
- Sphingosine (299 Da, Ligand)
- Light chain (25 kDa, Protein from Homo sapiens)
- Vp1 (32 kDa, Protein from Enterovirus A71)
- Heavy chain (26 kDa, Protein from Homo sapiens)
- Enterovirus a71 in complex with a protective antibody 38-3-11a fab (Virus)
Structure of EV71 in complex with a protective antibody 38-1-10A Fab
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 6z3q
Q-score: 0.602
Huang KA, Zhou D, Fry EE, Kotecha A, Huang PN, Yang SL, Tsao KC, Huang YC, Lin TY, Ren J, Stuart DI
Nat Commun (2020) 11 pp. 5253-5253 [ Pubmed: 33067459 DOI: doi:10.1038/s41467-020-19013-3 ]
- Sphingosine (299 Da, Ligand)
- Enterovirus a71 (Complex from Enterovirus A71)
- Human antibody (Complex from Homo sapiens)
- Enterovirus a71 with human antibody (Virus)
- Vp1 (32 kDa, Protein from Enterovirus A71)
- Vp3 (26 kDa, Protein from Enterovirus A71)
- Heavy chain (25 kDa, Protein from Homo sapiens)
- Vp4 (6 kDa, Protein from Enterovirus A71)
- Light chain (23 kDa, Protein from Homo sapiens)
- Vp2 (27 kDa, Protein from Enterovirus A71)
Structure of the EVA71 strain 11316 capsid
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 6uh1
Q-score: 0.469
Martinez-Gualda B, Sun L, Marti-Mari O, Noppen S, Abdelnabi R, Bator CM, Quesada E, Delang L, Mirabelli C, Lee H, Schols D, Neyts J, Hafenstein S, Camarasa MJ, Gago F, San-Felix A
J Med Chem (2020) 63 pp. 349-368 [ Pubmed: 31809045 DOI: doi:10.1021/acs.jmedchem.9b01737 ]
- Sphingosine (299 Da, Ligand)
- Vp4 (7 kDa, Protein from Enterovirus A71)
- Vp1 (32 kDa, Protein from Enterovirus A71)
- Vp3 (26 kDa, Protein from Enterovirus A71)
- Vp2 (27 kDa, Protein from Enterovirus A71)
- Enterovirus a71 (Virus from Enterovirus A71)
EV-A71 strain 11316 complexed with MADAL compound 22
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 6uh6
Q-score: 0.441
Martinez-Gualda B, Sun L, Marti-Mari O, Noppen S, Abdelnabi R, Bator CM, Quesada E, Delang L, Mirabelli C, Lee H, Schols D, Neyts J, Hafenstein S, Camarasa MJ, Gago F, San-Felix A
J Med Chem (2020) 63 pp. 349-368 [ DOI: doi:10.1021/acs.jmedchem.9b01737 Pubmed: 31809045 ]
- Vp3 (26 kDa, Protein from Enterovirus A71)
- Vp1 (32 kDa, Protein from Enterovirus A71)
- Vp4 (7 kDa, Protein from Enterovirus A71)
- Sphingosine (299 Da, Ligand)
- Enterovirus a71 (Virus from Enterovirus A71)
- Vp2 (26 kDa, Protein from Enterovirus A71)
EV-A71 strain 11316 complexed with MADAL compound 30
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 6uh7
Q-score: 0.468
Martinez-Gualda B, Sun L, Marti-Mari O, Noppen S, Abdelnabi R, Bator CM, Quesada E, Delang L, Mirabelli C, Lee H, Schols D, Neyts J, Hafenstein S, Camarasa MJ, Gago F, San-Felix A
J Med Chem (2020) 63 pp. 349-368 [ Pubmed: 31809045 DOI: doi:10.1021/acs.jmedchem.9b01737 ]
- Sphingosine (299 Da, Ligand)
- Vp4 (7 kDa, Protein from Enterovirus A71)
- Vp1 (32 kDa, Protein from Enterovirus A71)
- Vp3 (26 kDa, Protein from Enterovirus A71)
- Vp2 (27 kDa, Protein from Enterovirus A71)
- Enterovirus a71 (Virus from Enterovirus A71)