Cryo-EM structure of enterovirus A71 mature virion in complex with Fab h1A6.2
Zhu R, Wu Y, Huang Y, Jiang Y, Jiang Y, Zhang D, Sun H, Zhou Z, Zhou L, Weng S, Chen H, Chen X, Ning W, Zou Y, He M, Yang H, Deng W, Li Y, Chen Z, Ye X, Han J, Yin Z, Zhao H, Liu C, Que Y, Fang M, Yu H, Zhang J, Luo W, Li S, Zheng Q, Xu L, Xia N, Cheng T
Nat Microbiol (2024) 9 pp. 2939-2953 [ Pubmed: 39424982 DOI: doi:10.1038/s41564-024-01822-7 ]
- Enterovirus a71 (Virus from Enterovirus A71)
- Capsid protein vp2 (27 kDa, Protein from Enterovirus A71)
- Capsid protein vp4 (7 kDa, Protein from Enterovirus A71)
- Capsid protein vp1 (32 kDa, Protein from Enterovirus A71)
- Sphingosine (299 Da, Ligand)
- Enterovirus a71 mature virion in complex with fab h1a6.2 (Complex)
- Fab h1a6.2 (Complex from Mus)
- Capsid protein vp3 (26 kDa, Protein from Enterovirus A71)
Cryo-EM structure of enterovirus A71 mature virion
Zhu R, Wu Y, Huang Y, Jiang Y, Jiang Y, Zhang D, Sun H, Zhou Z, Zhou L, Weng S, Chen H, Chen X, Ning W, Zou Y, He M, Yang H, Deng W, Li Y, Chen Z, Ye X, Han J, Yin Z, Zhao H, Liu C, Que Y, Fang M, Yu H, Zhang J, Luo W, Li S, Zheng Q, Xu L, Xia N, Cheng T
Nat Microbiol (2024) 9 pp. 2939-2953 [ Pubmed: 39424982 DOI: doi:10.1038/s41564-024-01822-7 ]
- Enterovirus a71 (Virus from Enterovirus A71)
- Capsid protein vp2 (27 kDa, Protein from Enterovirus A71)
- Capsid protein vp4 (7 kDa, Protein from Enterovirus A71)
- Capsid protein vp1 (32 kDa, Protein from Enterovirus A71)
- Sphingosine (299 Da, Ligand)
- Capsid protein vp3 (26 kDa, Protein from Enterovirus A71)
Structure of EV71 in complex with a protective antibody 38-3-11A Fab
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 6z3p
Q-score: 0.623
Huang KA, Zhou D, Fry EE, Kotecha A, Huang PN, Yang SL, Tsao KC, Huang YC, Lin TY, Ren J, Stuart DI
Nat Commun (2020) 11 pp. 5253-5253 [ Pubmed: 33067459 DOI: doi:10.1038/s41467-020-19013-3 ]
- Enterovirus a71 (Complex from Enterovirus A71)
- Heavy chain (26 kDa, Protein from Homo sapiens)
- Enterovirus a71 in complex with a protective antibody 38-3-11a fab (Virus)
- Vp3 (26 kDa, Protein from Enterovirus A71)
- Vp4 (6 kDa, Protein from Enterovirus A71)
- Protective antibody 38-3-11a fab (Complex from Homo sapiens)
- Sphingosine (299 Da, Ligand)
- Vp2 (27 kDa, Protein from Enterovirus A71)
- Vp1 (32 kDa, Protein from Enterovirus A71)
- Light chain (25 kDa, Protein from Homo sapiens)
Structure of EV71 in complex with a protective antibody 38-1-10A Fab
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 6z3q
Q-score: 0.602
Huang KA, Zhou D, Fry EE, Kotecha A, Huang PN, Yang SL, Tsao KC, Huang YC, Lin TY, Ren J, Stuart DI
Nat Commun (2020) 11 pp. 5253-5253 [ Pubmed: 33067459 DOI: doi:10.1038/s41467-020-19013-3 ]
- Enterovirus a71 (Complex from Enterovirus A71)
- Vp3 (26 kDa, Protein from Enterovirus A71)
- Heavy chain (25 kDa, Protein from Homo sapiens)
- Vp4 (6 kDa, Protein from Enterovirus A71)
- Enterovirus a71 with human antibody (Virus)
- Light chain (23 kDa, Protein from Homo sapiens)
- Sphingosine (299 Da, Ligand)
- Vp2 (27 kDa, Protein from Enterovirus A71)
- Vp1 (32 kDa, Protein from Enterovirus A71)
- Human antibody (Complex from Homo sapiens)
Structure of the EVA71 strain 11316 capsid
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 6uh1
Q-score: 0.469
Martinez-Gualda B, Sun L, Marti-Mari O, Noppen S, Abdelnabi R, Bator CM, Quesada E, Delang L, Mirabelli C, Lee H, Schols D, Neyts J, Hafenstein S, Camarasa MJ, Gago F, San-Felix A
J Med Chem (2020) 63 pp. 349-368 [ Pubmed: 31809045 DOI: doi:10.1021/acs.jmedchem.9b01737 ]
- Enterovirus a71 (Virus from Enterovirus A71)
- Vp3 (26 kDa, Protein from Enterovirus A71)
- Sphingosine (299 Da, Ligand)
- Vp1 (32 kDa, Protein from Enterovirus A71)
- Vp4 (7 kDa, Protein from Enterovirus A71)
- Vp2 (27 kDa, Protein from Enterovirus A71)
EV-A71 strain 11316 complexed with MADAL compound 22
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 6uh6
Q-score: 0.441
Martinez-Gualda B, Sun L, Marti-Mari O, Noppen S, Abdelnabi R, Bator CM, Quesada E, Delang L, Mirabelli C, Lee H, Schols D, Neyts J, Hafenstein S, Camarasa MJ, Gago F, San-Felix A
J Med Chem (2020) 63 pp. 349-368 [ Pubmed: 31809045 DOI: doi:10.1021/acs.jmedchem.9b01737 ]
- Enterovirus a71 (Virus from Enterovirus A71)
- Vp3 (26 kDa, Protein from Enterovirus A71)
- Vp2 (26 kDa, Protein from Enterovirus A71)
- Sphingosine (299 Da, Ligand)
- Vp1 (32 kDa, Protein from Enterovirus A71)
- Vp4 (7 kDa, Protein from Enterovirus A71)
EV-A71 strain 11316 complexed with MADAL compound 30
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 6uh7
Q-score: 0.468
Martinez-Gualda B, Sun L, Marti-Mari O, Noppen S, Abdelnabi R, Bator CM, Quesada E, Delang L, Mirabelli C, Lee H, Schols D, Neyts J, Hafenstein S, Camarasa MJ, Gago F, San-Felix A
J Med Chem (2020) 63 pp. 349-368 [ Pubmed: 31809045 DOI: doi:10.1021/acs.jmedchem.9b01737 ]
- Enterovirus a71 (Virus from Enterovirus A71)
- Vp3 (26 kDa, Protein from Enterovirus A71)
- Sphingosine (299 Da, Ligand)
- Vp1 (32 kDa, Protein from Enterovirus A71)
- Vp4 (7 kDa, Protein from Enterovirus A71)
- Vp2 (27 kDa, Protein from Enterovirus A71)
Structure of EV71 complexed with its receptor SCARB2
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6i2k
Q-score: 0.437
Zhou D, Zhao Y, Kotecha A, Fry EE, Kelly JT, Wang X, Rao Z, Rowlands DJ, Ren J, Stuart DI
Nat Microbiol (2019) 4 pp. 414-419 [ Pubmed: 30531980 DOI: doi:10.1038/s41564-018-0319-z ]
- Polyprotein (6 kDa, Protein from Enterovirus A71)
- Polyprotein (27 kDa, Protein from Enterovirus A71)
- Complex of ev71 and scarb2 (Complex)
- Enterovirus a71 (Virus from Enterovirus A71)
- Scarb2 (Complex from Homo sapiens)
- Polyprotein (32 kDa, Protein from Enterovirus A71)
- 1-(2-aminopyridin-4-yl)-3-[(3s)-5-{4-[(e)-(ethoxyimino)methyl]phenoxy}-3-methylpentyl]imidazolidin-2-one (425 Da, Ligand)
- Polyprotein (26 kDa, Protein from Enterovirus A71)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Lysosome membrane protein 2 (47 kDa, Protein from Homo sapiens)