Inward-facing structure of human EAAT2 in the WAY213613-bound state
Resolution: 3.49 Å
EM Method: Single-particle
Fitted PDBs: 7vr7
Q-score: 0.553
Kato T, Kusakizako T, Jin C, Zhou X, Ohgaki R, Quan L, Xu M, Okuda S, Kobayashi K, Yamashita K, Nishizawa T, Kanai Y, Nureki O
Nat Commun (2022) 13 pp. 4714-4714 [ Pubmed: 35953475 DOI: doi:10.1038/s41467-022-32442-6 ]
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- (2s)-2-azanyl-4-[[4-[2-bromanyl-4,5-bis(fluoranyl)phenoxy]phenyl]amino]-4-oxidanylidene-butanoic acid (415 Da, Ligand)
- Eaat2 (Complex from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Excitatory amino acid transporter 2 (63 kDa, Protein from Homo sapiens)
Inward-facing structure of human EAAT2 in the substrate-free state
Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 7vr8
Q-score: 0.431
Kato T, Kusakizako T, Jin C, Zhou X, Ohgaki R, Quan L, Xu M, Okuda S, Kobayashi K, Yamashita K, Nishizawa T, Kanai Y, Nureki O
Nat Commun (2022) 13 pp. 4714-4714 [ Pubmed: 35953475 DOI: doi:10.1038/s41467-022-32442-6 ]
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- Eaat2 (Complex from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Excitatory amino acid transporter 2 (63 kDa, Protein from Homo sapiens)
Structure of human excitatory amino acid transporter 2 (EAAT2) in complex with glutamate
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7xr4
Q-score: 0.532
Zhang Z, Chen H, Geng Z, Yu Z, Li H, Dong Y, Zhang H, Huang Z, Jiang J, Zhao Y
Nat Commun (2022) 13 pp. 3329-3329 [ DOI: doi:10.1038/s41467-022-31031-x Pubmed: 35680945 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- Transporter (Complex from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Excitatory amino acid transporter 2 (62 kDa, Protein from Homo sapiens)
- Glutamic acid (147 Da, Ligand)
Structure of human excitatory amino acid transporter 2 (EAAT2) in complex with WAY-213613
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7xr6
Q-score: 0.511
Zhang Z, Chen H, Geng Z, Yu Z, Li H, Dong Y, Zhang H, Huang Z, Jiang J, Zhao Y
Nat Commun (2022) 13 pp. 3329-3329 [ DOI: doi:10.1038/s41467-022-31031-x Pubmed: 35680945 ]
- Excitatory amino acid transporter 2 (62 kDa, Protein from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Transporter (Complex from Homo sapiens)
- (2s)-2-azanyl-4-[[4-[2-bromanyl-4,5-bis(fluoranyl)phenoxy]phenyl]amino]-4-oxidanylidene-butanoic acid (415 Da, Ligand)
- Dodecyl beta-d-glucopyranoside (348 Da, Ligand)