Human NEXT dimer in complex with the nuclear RNA exosome
Gerlach P, Garland W, Lingaraju M, Salerno-Kochan A, Bonneau F, Basquin J, Jensen TH, Conti E
Mol Cell (2022) 82 pp. 2505-2518.e7 [ Pubmed: 35688157 DOI: doi:10.1016/j.molcel.2022.04.011 ]
- Zinc finger cchc domain-containing protein 8 (Protein from Homo sapiens)
- Nuclear nucleic acid-binding protein c1d (Protein from Homo sapiens)
- Rna 5 prime hairpin u60 (RNA from synthetic construct)
- Exosome complex component rrp46 (Protein from Homo sapiens)
- Human next dimer in complex with the nuclear rna exosome (Complex from Homo sapiens)
- Human next dimer in complex with the nuclear rna exosome (Complex)
- Exosome rna helicase mtr4 (Protein from Homo sapiens)
- M-phase phosphoprotein 6 (Protein from Homo sapiens)
- Exosome complex component mtr3 (Protein from Homo sapiens)
- Rna 5 prime hairpin u60 (Complex from synthetic construct)
- Exosome complex component rrp42 (Protein from Homo sapiens)
- Exosome complex component rrp45 (Protein from Homo sapiens)
- Exosome complex component rrp40 (Protein from Homo sapiens)
- Exosome complex component csl4 (Protein from Homo sapiens)
- Exosome component 10 (Protein from Homo sapiens)
- Rna-binding protein 7 (Protein from Homo sapiens)
- Exosome complex component rrp41 (Protein from Homo sapiens)
- Exosome complex exonuclease rrp44 (Protein from Homo sapiens)
- Exosome complex component rrp4 (Protein from Homo sapiens)
Human nuclear RNA exosome EXO-10-MPP6 complex
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6h25
Q-score: 0.427
Gerlach P, Schuller JM, Bonneau F, Basquin J, Reichelt P, Falk S, Conti E
eLife (2018) 7 [ DOI: doi:10.7554/eLife.38686 Pubmed: 30047866 ]
- Exosome complex component rrp42 (32 kDa, Protein from Homo sapiens)
- U44 ssrna (Complex from synthetic construct)
- Exosome complex component rrp43 (30 kDa, Protein from Homo sapiens)
- Exosome complex component rrp41 (26 kDa, Protein from Homo sapiens)
- Human nuclear rna exosome exo-14 complex (Complex)
- Exosome complex (Complex from Homo sapiens)
- Exosome complex component rrp45 (49 kDa, Protein from Homo sapiens)
- Exosome complex component rrp40 (30 kDa, Protein from Homo sapiens)
- Exosome complex component csl4 (21 kDa, Protein from Homo sapiens)
- Exosome complex component mtr3 (28 kDa, Protein from Homo sapiens)
- M-phase phosphoprotein 6 (19 kDa, Protein from Homo sapiens)
- Exosome complex component rrp46 (25 kDa, Protein from Homo sapiens)
- Exosome complex component rrp4 (33 kDa, Protein from Homo sapiens)
- Exosome complex exonuclease rrp44 (109 kDa, Protein from Homo sapiens)
- U44 ssrna (13 kDa, RNA from synthetic construct)
Human nuclear exosome-MTR4 RNA complex - overall reconstruction
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 6d6q
Q-score: 0.413
Weick EM, Puno MR, Januszyk K, Zinder JC, DiMattia MA, Lima CD
Cell (2018) 173 pp. 1663- [ DOI: doi:10.1016/j.cell.2018.05.041 Pubmed: 29906447 ]
- Exosome complex component mtr3 (28 kDa, Protein from Homo sapiens)
- Exosome complex component csl4 (21 kDa, Protein from Homo sapiens)
- M-phase phosphoprotein 6 (19 kDa, Protein from Homo sapiens)
- Exosome complex component rrp41 (26 kDa, Protein from Homo sapiens)
- Exosome complex component rrp46 (25 kDa, Protein from Homo sapiens)
- Exosome rna helicase mtr4 (118 kDa, Protein from Homo sapiens)
- Exosome complex component rrp4 (33 kDa, Protein from Homo sapiens)
- Human nuclear exosome-mtr4 helicase captured after unwinding a dna/rna substrate (690 kDa, Complex from Homo sapiens)
- Dna/rna (62-mer) (19 kDa, Macromolecule from synthetic construct)
- Zinc ion (65 Da, Ligand)
- Exosome complex component rrp45 (52 kDa, Protein from Homo sapiens)
- Exosome complex component rrp42 (32 kDa, Protein from Homo sapiens)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Exosome component 10 (86 kDa, Protein from Homo sapiens)
- Exosome complex component rrp40 (29 kDa, Protein from Homo sapiens)
- Exosome complex component rrp43 (30 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Exosome complex exonuclease rrp44 (109 kDa, Protein from Homo sapiens)
- Rna (5'-r(*ap*gp*cp*ap*cp*cp*gp*up*ap*ap*ap*gp*ap*cp*gp*c)-3') (5 kDa, RNA from synthetic construct)
Human nuclear exosome-MTR4 RNA complex - composite map after focused reconstruction
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 6d6r
Q-score: 0.456
Weick EM, Puno MR, Januszyk K, Zinder JC, DiMattia MA, Lima CD
Cell (2018) 173 pp. 1663- [ Pubmed: 29906447 DOI: doi:10.1016/j.cell.2018.05.041 ]
- Exosome complex component mtr3 (28 kDa, Protein from Homo sapiens)
- Exosome component 10 (86 kDa, Protein from Homo sapiens)
- Exosome complex component rrp40 (29 kDa, Protein from Homo sapiens)
- Human nuclear exosome-mtr4 helicase captured after unwinding a dna/rna substrate (690 kDa, Complex from Homo sapiens)
- Dna/rna (62-mer) (19 kDa, Macromolecule from synthetic construct)
- Exosome complex component rrp4 (33 kDa, Protein from Homo sapiens)
- Exosome rna helicase mtr4 (118 kDa, Protein from Homo sapiens)
- Rna (5'-r(*ap*gp*cp*ap*cp*cp*gp*up*ap*ap*ap*gp*ap*cp*gp*c)-3') (5 kDa, RNA from synthetic construct)
- Exosome complex component rrp43 (30 kDa, Protein from Homo sapiens)
- Exosome complex component rrp45 (52 kDa, Protein from Homo sapiens)
- Exosome complex component csl4 (21 kDa, Protein from Homo sapiens)
- Exosome complex component rrp41 (26 kDa, Protein from Homo sapiens)
- Exosome complex component rrp42 (32 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Exosome complex exonuclease rrp44 (109 kDa, Protein from Homo sapiens)
- M-phase phosphoprotein 6 (19 kDa, Protein from Homo sapiens)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Exosome complex component rrp46 (25 kDa, Protein from Homo sapiens)