Structure of the prefusion HKU5-19s Spike trimer (conformation 1)
Resolution: 2.0 Å
EM Method: Single-particle
Fitted PDBs: 9ea0
Q-score: 0.702
Park YJ, Liu C, Lee J, Brown JT, Ma CB, Liu P, Gen R, Xiong Q, Zepeda SK, Stewart C, Addetia A, Craig CJ, Tortorici MA, Alshukairi AN, Starr TN, Yan H, Veesler D
Cell (2025) [ Pubmed: 39922192 DOI: doi:10.1016/j.cell.2024.12.032 ]
- Water (18 Da, Ligand)
- Prefusion hku5-19s s trimer (Complex from Homo sapiens)
- Folic acid (441 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Spike glycoprotein (150 kDa, Protein from Pipistrellus bat coronavirus HKU5)
- Linoleic acid (280 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of the prefusion HKU5-19s Spike trimer (conformation 2)
Resolution: 2.0 Å
EM Method: Single-particle
Fitted PDBs: 9eh8
Q-score: 0.741
Park YJ, Liu C, Lee J, Brown JT, Ma CB, Liu P, Gen R, Xiong Q, Zepeda SK, Stewart C, Addetia A, Craig CJ, Tortorici MA, Alshukairi AN, Starr TN, Yan H, Veesler D
Cell (2025) [ Pubmed: 39922192 DOI: doi:10.1016/j.cell.2024.12.032 ]
- Water (18 Da, Ligand)
- Prefusion hku5-19s s trimer (Complex from Homo sapiens)
- Folic acid (441 Da, Ligand)
- Spike glycoprotein (150 kDa, Protein from Pipistrellus bat coronavirus HKU5)
- Linoleic acid (280 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
MERS-CoV S bound to the broadly neutralizing B6 Fab fragment (C3 refinement)
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 7m5e
Q-score: 0.605
Sauer MM, Tortorici MA, Park YJ, Walls AC, Homad L, Acton OJ, Bowen JE, Wang C, Xiong X, de van der Schueren W, Quispe J, Hoffstrom BG, Bosch BJ, McGuire AT, Veesler D
Nat Struct Mol Biol (2021) 28 pp. 478-486 [ Pubmed: 33981021 DOI: doi:10.1038/s41594-021-00596-4 ]
- Spike glycoprotein (149 kDa, Protein from Middle East respiratory syndrome-related coronavirus)
- Folic acid (441 Da, Ligand)
- N-acetyl-alpha-neuraminic acid (309 Da, Ligand)
- Mers-cov s ectodomain trimer bound to the b6 fab fragment in the presence of 100 mm neuraminic acid (Complex)
- Mers-cov s ectodomain trimer (Complex from Middle East respiratory syndrome-related coronavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- B6 fab fragment (Complex from Mus musculus)
MERS-CoV S structure in complex with 5-N-acetyl neuraminic acid
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 6q04
Q-score: 0.569
Park YJ, Walls AC, Wang Z, Sauer MM, Li W, Tortorici MA, Bosch BJ, DiMaio F, Veesler D
Nat Struct Mol Biol (2019) 26 pp. 1151-1157 [ DOI: doi:10.1038/s41594-019-0334-7 Pubmed: 31792450 ]
- Mers-cov s ectodomain in complex with 5-n-acetyl neuraminic acid (Complex from Middle East respiratory syndrome-related coronavirus)
- Water (18 Da, Ligand)
- Spike glycoprotein (149 kDa, Protein from Human betacoronavirus 2c EMC/2012)
- Folic acid (441 Da, Ligand)
- N-acetyl-alpha-neuraminic acid (309 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
MERS-CoV S structure in complex with sialyl-lewisX
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 6q05
Q-score: 0.579
Park YJ, Walls AC, Wang Z, Sauer MM, Li W, Tortorici MA, Bosch BJ, DiMaio F, Veesler D
Nat Struct Mol Biol (2019) 26 pp. 1151-1157 [ DOI: doi:10.1038/s41594-019-0334-7 Pubmed: 31792450 ]
- Mers-cov s ectodomain in complex with 5-n-acetyl neuraminic acid (Complex from Middle East respiratory syndrome-related coronavirus)
- Water (18 Da, Ligand)
- Spike glycoprotein (149 kDa, Protein from Human betacoronavirus 2c EMC/2012)
- Folic acid (441 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
MERS-CoV S structure in complex with 2,3-sialyl-N-acetyl-lactosamine
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 6q06
Q-score: 0.574
Park YJ, Walls AC, Wang Z, Sauer MM, Li W, Tortorici MA, Bosch BJ, DiMaio F, Veesler D
Nat Struct Mol Biol (2019) 26 pp. 1151-1157 [ DOI: doi:10.1038/s41594-019-0334-7 Pubmed: 31792450 ]
- Mers-cov s ectodomain in complex with 5-n-acetyl neuraminic acid (Complex from Middle East respiratory syndrome-related coronavirus)
- Water (18 Da, Ligand)
- Spike glycoprotein (149 kDa, Protein from Human betacoronavirus 2c EMC/2012)
- Folic acid (441 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
MERS-CoV S structure in complex with 2,6-sialyl-N-acetyl-lactosamine
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 6q07
Q-score: 0.543
Park YJ, Walls AC, Wang Z, Sauer MM, Li W, Tortorici MA, Bosch BJ, DiMaio F, Veesler D
Nat Struct Mol Biol (2019) 26 pp. 1151-1157 [ DOI: doi:10.1038/s41594-019-0334-7 Pubmed: 31792450 ]
- Mers-cov s ectodomain in complex with 5-n-acetyl neuraminic acid (Complex from Middle East respiratory syndrome-related coronavirus)
- Water (18 Da, Ligand)
- Spike glycoprotein (149 kDa, Protein from Human betacoronavirus 2c EMC/2012)
- Folic acid (441 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)