CH235.12 Fab bound to the HIV-1 CH505.M5 SOSIP
Resolution: 4.08 Å
EM Method: Single-particle
Fitted PDBs: 8vh1
Q-score: 0.404
Henderson R, Anasti K, Manne K, Stalls V, Saunders C, Bililign Y, Williams A, Bubphamala P, Montani M, Kachhap S, Li J, Jaing C, Newman A, Cain DW, Lu X, Venkatayogi S, Berry M, Wagh K, Korber B, Saunders KO, Tian M, Alt F, Wiehe K, Acharya P, Alam SM, Haynes BF
Nat Commun (2024) 15 pp. 9503-9503 [ Pubmed: 39489734 DOI: doi:10.1038/s41467-024-53120-9 ]
- Antibody fab bound hiv-1 ectodomain (Complex from Human immunodeficiency virus 1)
- Ch235.i60 fab light chain (23 kDa, Protein from Homo sapiens)
- Ch505.m5 sosip gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
- Ch505.m5 sosip gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Ch235.i60 fab heavy chain (23 kDa, Protein from Homo sapiens)
CH235.12 Fab bound to the HIV-1 CH505.M5 SOSIP
Resolution: 4.31 Å
EM Method: Single-particle
Fitted PDBs: 8vh2
Q-score: 0.32
Henderson R, Anasti K, Manne K, Stalls V, Saunders C, Bililign Y, Williams A, Bubphamala P, Montani M, Kachhap S, Li J, Jaing C, Newman A, Cain DW, Lu X, Venkatayogi S, Berry M, Wagh K, Korber B, Saunders KO, Tian M, Alt F, Wiehe K, Acharya P, Alam SM, Haynes BF
Nat Commun (2024) 15 pp. 9503-9503 [ Pubmed: 39489734 DOI: doi:10.1038/s41467-024-53120-9 ]
- Ch235.12 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Ch235.12 fab light chain (23 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp160 (18 kDa, Protein from Human immunodeficiency virus 1)
- Antibody fab bound hiv-1 ectodomain (Complex from Human immunodeficiency virus 1)
- Ch505.m5.g458y sosip gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
SARS-CoV-2 S protein in complex with pT1644 Fab
Resolution: 4.11 Å
EM Method: Single-particle
Fitted PDBs: 8bg6
Q-score: 0.45
Stein CS, Hansen G, Ssebyatika GL, Stroeh L, Benecke T, Menz S, Waldmann J-Y, Vollmer B, Tipp S, Ochulor O, Herold E, Schwarzloh B, Mutschall D, Zischke J-Y, Cordes A, Puppe W, Schneider T, Hinrichs I, Blasczyk R, Kleine-Weber H, Hoffmann M, Hoeper M, Kaiser FK, Gonzalez-Hernandez M, Armando FK, Ciurkiewicz M, Beythien G, Poehlmann S, Baumgaertner W, Gruenewald K, Osterhaus A, Schulz T, Krey T
To Be Published
- 3:3 pt1644 fab-spike complex (Complex)
- Spike protein s1 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Pt1644 fab (Complex from Homo sapiens)
- Pt1644 fab light chain (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (140 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Pt1644 fab heavy chain (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7m6h
Q-score: 0.254
Scheid JF, Barnes CO, Eraslan B, Hudak A, Keeffe JR, Cosimi LA, Brown EM, Muecksch F, Weisblum Y, Zhang S, Delorey T, Woolley AE, Ghantous F, Park SM, Phillips D, Tusi B, Huey-Tubman KE, Cohen AA, Gnanapragasam PNP, Rzasa K, Hatziioanno T, Durney MA, Gu X, Tada T, Landau NR, West Jr AP, Rozenblatt-Rosen O, Seaman MS, Baden LR, Graham DB, Deguine J, Bieniasz PD, Regev A, Hung D, Bjorkman PJ, Xavier RJ
Cell (2021) 184 pp. 3205- [ DOI: doi:10.1016/j.cell.2021.04.032 Pubmed: 34015271 ]
- Bg7-20 fab (Complex from Homo sapiens)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Bg7-20 fab light chain (22 kDa, Protein from Homo sapiens)
- Bg7-20 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Ternary complex of bg7-20 fab bound to sars-cov-2 spike trimer (720 kDa, Complex)
- Sars-cov-2 spike trimer (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7m6i
Q-score: 0.277
Scheid JF, Barnes CO, Eraslan B, Hudak A, Keeffe JR, Cosimi LA, Brown EM, Muecksch F, Weisblum Y, Zhang S, Delorey T, Woolley AE, Ghantous F, Park SM, Phillips D, Tusi B, Huey-Tubman KE, Cohen AA, Gnanapragasam PNP, Rzasa K, Hatziioanno T, Durney MA, Gu X, Tada T, Landau NR, West Jr AP, Rozenblatt-Rosen O, Seaman MS, Baden LR, Graham DB, Deguine J, Bieniasz PD, Regev A, Hung D, Bjorkman PJ, Xavier RJ
Cell (2021) 184 pp. 3205- [ DOI: doi:10.1016/j.cell.2021.04.032 Pubmed: 34015271 ]
- Ternary complex of bg1-24 fab bound to sars-cov-2 spike trimer (720 kDa, Complex)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Bg1-24 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Bg1-24 fab light chain (23 kDa, Protein from Homo sapiens)
- Bg1-24 fab (Complex from Homo sapiens)
- Sars-cov-2 spike trimer (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 4.8 Å
EM Method: Single-particle
Fitted PDBs: 7llk
Q-score: 0.236
Cottrell CA, Manne K, Kong R, Wang S, Zhou T, Chuang GY, Edwards RJ, Henderson R, Janowska K, Kopp M, Lin BC, Louder MK, Olia AS, Rawi R, Shen CH, Taft JD, Torres JL, Wu NR, Zhang B, Doria-Rose NA, Cohen MS, Haynes BF, Shapiro L, Ward AB, Acharya P, Mascola JR, Kwong PD
Cell Rep (2021) 37 pp. 109922-109922 [ DOI: doi:10.1016/j.celrep.2021.109922 Pubmed: 34731616 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Trimeric hiv-1 env in complex with vrc33.01 fab (Complex from Human immunodeficiency virus 1)
- 179nc75 fab light chain (23 kDa, Protein from Homo sapiens)
- 179nc75 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp120 (53 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Manne K, Stalls V, Hsu AL, Borgnia MJ, Stewart-Jones G, Lee MS, Bronkema N, Perfect J, Moody MA, Wiehe K, Bradley T, Kepler TB, Alam SM, Foulger A, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelso G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
bioRxiv (2020) https://doi.org/10.1101/2020.06.30.178921 [ DOI: doi:10.1101/2020.06.30.178921 ]
- Hiv env ch848.3.d0949.10.17chim.6r.ds.sosip.664 (Protein from Human immunodeficiency virus 1)
- Antibody dh898.1 fragment antigen binding (fab) light chain (Protein from Macaca mulatta)
- Antibody dh898.1 fragment antigen binding (fab) heavy chain (Protein from Macaca mulatta)
- Hiv env ch848.3.d0949.10.17chim.6r.ds.sosip.664 trimer (Complex from Human immunodeficiency virus 1)
- Antibody dh898.1 fragment antigen binding (fab) dimer (Complex from Macaca mulatta)
- Antibody dh898.1 fab-dimer bound near the cd4 binding site of hiv env ch848.3.d0949.10.17chim.6r.ds.sosip.664 trimer (94 kDa, Complex)
SARS-CoV-2 spike in complex with the S304 neutralizing antibody Fab fragment
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 7jw0
Q-score: 0.338
Piccoli L, Park YJ, Tortorici MA, Czudnochowski N, Walls AC, Beltramello M, Silacci-Fregni C, Pinto D, Rosen LE, Bowen JE, Acton OJ, Jaconi S, Guarino B, Minola A, Zatta F, Sprugasci N, Bassi J, Peter A, De Marco A, Nix JC, Mele F, Jovic S, Rodriguez BF, Gupta SV, Jin F, Piumatti G, Lo Presti G, Pellanda AF, Biggiogero M, Tarkowski M, Pizzuto MS, Cameroni E, Havenar-Daughton C, Smithey M, Hong D, Lepori V, Albanese E, Ceschi A, Bernasconi E, Elzi L, Ferrari P, Garzoni C, Riva A, Snell G, Sallusto F, Fink K, Virgin HW, Lanzavecchia A, Corti D, Veesler D
Cell (2020) 183 pp. 1024-1042.e21 [ DOI: doi:10.1016/j.cell.2020.09.037 Pubmed: 32991844 ]
- Sars-cov-2 spike in complex (Complex from Severe acute respiratory syndrome coronavirus 2)
- S304 fab heavy chain (23 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike in complex with the s304 neutralizing antibody fab fragment (Complex)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- S304 fab light chain (23 kDa, Protein from Homo sapiens)
- S304 neutralizing antibody fab fragment (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
EBOV GPdMuc (Makona) in complex with rEBOV-520 and rEBOV-548 Fabs
Resolution: 4.12 Å
EM Method: Single-particle
Fitted PDBs: 6pci
Q-score: 0.38
Gilchuk P, Murin CD, Milligan JC, Cross RW, Mire CE, Ilinykh PA, Huang K, Kuzmina N, Altman PX, Hui S, Gunn BM, Bryan AL, Davidson E, Doranz BJ, Turner HL, Alkutkar T, Flinko R, Orlandi C, Carnahan R, Nargi R, Bombardi RG, Vodzak ME, Li S, Okoli A, Ibeawuchi M, Ohiaeri B, Lewis GK, Alter G, Bukreyev A, Saphire EO, Geisbert TW, Ward AB, Crowe Jr JE
Immunity (2020) 52 pp. 388-403.e12 [ DOI: doi:10.1016/j.immuni.2020.01.001 Pubmed: 32023489 ]
- Rebov-548 fab (Complex)
- Rebov-520 fab light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Virion spike glycoprotein (31 kDa, Protein from Ebola virus)
- Ebola virus (makona) gp (Complex)
- Rebov-548 fab light chain (23 kDa, Protein from Homo sapiens)
- Rebov-520 fab (Complex)
- Virion spike glycoprotein,virion spike glycoprotein,ebola virus (makona) gp2 (22 kDa, Protein from Ebola virus)
- Rebov-520 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Ebov gpdmuc (makona) in complex with rebov-520 and rebov-548 fabs (450 kDa, Complex from Homo sapiens)
- Rebov-548 fab heavy chain (25 kDa, Protein from Homo sapiens)
Cryo-EM structure of HIV-1 neutralizing antibody DH270 UCA3 in complex with CH848 10.17DT Env
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6um5
Q-score: 0.347
Saunders KO, Wiehe K, Tian M, Acharya P, Bradley T, Alam SM, Go EP, Scearce R, Sutherland L, Henderson R, Hsu AL, Borgnia MJ, Chen H, Lu X, Wu NR, Watts B, Jiang C, Easterhoff D, Cheng HL, McGovern K, Waddicor P, Chapdelaine-Williams A, Eaton A, Zhang J, Rountree W, Verkoczy L, Tomai M, Lewis MG, Desaire HR, Edwards RJ, Cain DW, Bonsignori M, Montefiori D, Alt FW, Haynes BF
Science (2019) 366 [ Pubmed: 31806786 DOI: doi:10.1126/science.aay7199 ]
- Dh270 uca3 fab light chain (22 kDa, Protein from Homo sapiens)
- Dh270 uca3 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp160 (17 kDa, Protein from Human immunodeficiency virus 1)
- Dh270 uca3 fab bound to hiv-1 env ch848 10.17dt (360 kDa, Complex from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ch848 10.17 dt gp120 (51 kDa, Protein from Human immunodeficiency virus 1)