Cryo-EM structure of BG505 Env mutant A517E in complex with antibody ACS202 Fab
Reveiz M, Xu K, Lee M, Wang S, Olia AS, Harris DR, Liu K, Liu T, Schaub AJ, Stephens T, Wang Y, Zhang B, Huang R, Tsybovsky Y, Kwong PD, Rawi R
Front Immunol (2024) 15 pp. 1484029-1484029 [ Pubmed: 39611147 DOI: doi:10.3389/fimmu.2024.1484029 ]
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 env trimer complexed with antibody fab (Complex from Human immunodeficiency virus 1)
- Water (18 Da, Ligand)
- Antibody acs202 fab light chain (23 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp120 (53 kDa, Protein from Human immunodeficiency virus 1)
- Antibody acs202 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Antibody fab (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Antibody vFP53.02 in complex with HIV-1 envelope trimer BG505 DS-SOSIP
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8fr6
Q-score: 0.528
Sastry M, Changela A, Gorman J, Xu K, Chuang GY, Shen CH, Cheng C, Geng H, O'Dell S, Ou L, Rawi R, Reveiz M, Stewart-Jones GBE, Wang S, Zhang B, Zhou T, Biju A, Chambers M, Chen X, Corrigan AR, Lin BC, Louder MK, McKee K, Nazzari AF, Olia AS, Parchment DK, Sarfo EK, Stephens T, Stuckey J, Tsybovsky Y, Verardi R, Wang Y, Zheng CY, Chen Y, Doria-Rose NA, McDermott AB, Mascola JR, Kwong PD
J Virol (2023) 97 pp. e0160422-e0160422 [ Pubmed: 37098956 DOI: doi:10.1128/jvi.01604-22 ]
- Envelope glycoprotein gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Antibody fab (Complex from Mus musculus)
- Vfp53.02 fab heavy chain (24 kDa, Protein from Mus musculus)
- Hiv-1 env trimer bg505 ds-sosip (Complex from Human immunodeficiency virus 1)
- Complex of antibody fab vfp53.02 with hiv-1 env trimer bg505 ds-sosip (Complex)
- Vfp53.02 fab light chain (24 kDa, Protein from Mus musculus)
SARS-CoV-2 spike trimer in complex with Fab NA8, ensemble map
Chen Z, Zhang P, Matsuoka Y, Tsybovsky Y, West K, Santos C, Boyd LF, Nguyen H, Pomerenke A, Stephens T, Olia AS, Zhang B, De Giorgi V, Holbrook MR, Gross R, Postnikova E, Garza NL, Johnson RF, Margulies DH, Kwong PD, Alter HJ, Buchholz UJ, Lusso P, Farci P
Cell Rep (2022) 41 pp. 111528-111528 [ Pubmed: 36302375 DOI: doi:10.1016/j.celrep.2022.111528 ]
- Sars-cov-2 s6p spike trimer in complex with fab na8 (580 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Na8 fab light chain (Protein from Homo sapiens)
- Sars-cov-2 s6p spike trimer (Protein from Severe acute respiratory syndrome coronavirus 2)
- Na8 fab heavy chain (Protein from Homo sapiens)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7uap
Q-score: 0.384
Wang Z, Muecksch F, Cho A, Gaebler C, Hoffmann HH, Ramos V, Zong S, Cipolla M, Johnson B, Schmidt F, DaSilva J, Bednarski E, Ben Tanfous T, Raspe R, Yao K, Lee YE, Chen T, Turroja M, Milard KG, Dizon J, Kaczynska A, Gazumyan A, Oliveira TY, Rice CM, Caskey M, Bieniasz PD, Hatziioannou T, Barnes CO, Nussenzweig MC
Immunity (2022) 55 pp. 998-1012.e8 [ DOI: doi:10.1016/j.immuni.2022.04.003 Pubmed: 35447092 ]
- C1520 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- C1520 fab light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 s 6p + c1520 fab fragments (700 kDa, Complex from Homo sapiens)