Cryo-EM structure of E. coli FimH lectin domain bound to Fabs 440-2 and 454-3
Resolution: 4.24 Å
EM Method: Single-particle
Fitted PDBs: 9d6f
Q-score: 0.412
Silmon de Monerri NC, Che Y, Lees JA, Jasti J, Wu H, Griffor MC, Kodali S, Hawkins JC, Lypowy J, Ponce C, Curley K, Esadze A, Carcamo J, Keeney D, Illenberger A, Matsuka YV, Shanker S, Chorro L, Gribenko AV, Han S, Anderson AS, Donald RGK
To Be Published
- Fimh-dsg tm (Complex from Escherichia coli)
- Fab 440-2 (Complex from Mus musculus)
- 440-2 fab light chain (24 kDa, Protein from Mus musculus)
- Fimh-dsg tm in complex with fabs 440-2 and 445-3 (Complex)
- 445-3 fab heavy chain (24 kDa, Protein from Mus musculus)
- Fab 445-3 (Complex from Mus musculus)
- 440-2 fab heavy chain (24 kDa, Protein from Mus musculus)
- 445-3 fab light chain (23 kDa, Protein from Mus musculus)
- Type 1 fimbrin d-mannose specific adhesin fimh, donor strand complemented with fimg peptide 'triple mutant' (32 kDa, Protein from Escherichia coli)
The Cryo-EM structure of a complex between GAD65 and b96.11 Fab
Resolution: 7.3 Å
EM Method: Single-particle
Fitted PDBs: 7lz6
Q-score: 0.139
Stander SHD, Reboul CF, Le SN, Williams DE, Chandler PG, Costa MGS, Hoke DE, Jimma JDT, Fodor J, Fenalti G, Mannering SI, Porebski BT, Schofield P, Christ D, Buckle M, McGowan S, Elmlund D, Rand KD, Buckle AM
bioRxiv (2024) [ DOI: doi:10.1101/2024.03.18.585568 ]
- Glutamate decarboxylase 2 (56 kDa, Protein from Homo sapiens)
- B96.11 fab light chain (23 kDa, Protein from Homo sapiens)
- Gad65-b96.11 complex (Complex from Homo sapiens)
- B96.11 fab heavy chain (24 kDa, Protein from Homo sapiens)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 9asd
Q-score: 0.506
Rosen LE, Tortorici MA, De Marco A, Pinto D, Foreman WB, Taylor AL, Park YJ, Bohan D, Rietz T, Errico JM, Hauser K, Dang HV, Chartron JW, Giurdanella M, Cusumano G, Saliba C, Zatta F, Sprouse KR, Addetia A, Zepeda SK, Brown J, Lee J, Dellota Jr E, Rajesh A, Noack J, Tao Q, DaCosta Y, Tsu B, Acosta R, Subramanian S, de Melo GD, Kergoat L, Zhang I, Liu Z, Guarino B, Schmid MA, Schnell G, Miller JL, Lempp FA, Czudnochowski N, Cameroni E, Whelan SPJ, Bourhy H, Purcell LA, Benigni F, di Iulio J, Pizzuto MS, Lanzavecchia A, Telenti A, Snell G, Corti D, Veesler D, Starr TN
Cell (2024) 187 pp. 7196- [ Pubmed: 39383863 DOI: doi:10.1016/j.cell.2024.09.026 ]
- Vir-7229 fab heavy chain (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ba 2.86 rbd - s2v29 complex (local refinement) (Complex from Sarbecovirus)
- Spike glycoprotein (141 kDa, Protein from Homo sapiens)
- Vir-7229 fab light chain (11 kDa, Protein from Homo sapiens)
VIR-7229 Fab fragment bound the BA.2.86 spike trimer (global refinement)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9au2
Q-score: 0.499
Rosen LE, Tortorici MA, De Marco A, Pinto D, Foreman WB, Taylor AL, Park YJ, Bohan D, Rietz T, Errico JM, Hauser K, Dang HV, Chartron JW, Giurdanella M, Cusumano G, Saliba C, Zatta F, Sprouse KR, Addetia A, Zepeda SK, Brown J, Lee J, Dellota Jr E, Rajesh A, Noack J, Tao Q, DaCosta Y, Tsu B, Acosta R, Subramanian S, de Melo GD, Kergoat L, Zhang I, Liu Z, Guarino B, Schmid MA, Schnell G, Miller JL, Lempp FA, Czudnochowski N, Cameroni E, Whelan SPJ, Bourhy H, Purcell LA, Benigni F, di Iulio J, Pizzuto MS, Lanzavecchia A, Telenti A, Snell G, Corti D, Veesler D, Starr TN
Cell (2024) 187 pp. 7196- [ Pubmed: 39383863 DOI: doi:10.1016/j.cell.2024.09.026 ]
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Vir-7229 fab light chain (23 kDa, Protein from Homo sapiens)
- Vir-7229 fab heavy chain (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand from Severe acute respiratory syndrome coronavirus 2)
- Ba.2.86 spike glycoprotein in complex with vir-7229 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
Complex of NPR1 ectodomain with ANP plus an allosteric activating antibody, REGN5381
Resolution: 3.08 Å
EM Method: Single-particle
Fitted PDBs: 8tg9
Q-score: 0.495
Dunn ME, Kithcart A, Kim JH, Ho AJ, Franklin MC, Romero Hernandez A, de Hoon J, Botermans W, Meyer J, Jin X, Zhang D, Torello J, Jasewicz D, Kamat V, Garnova E, Liu N, Rosconi M, Pan H, Karnik S, Burczynski ME, Zheng W, Rafique A, Nielsen JB, De T, Verweij N, Pandit A, Locke A, Chalasani N, Melander O, Schwantes-An TH, Baras A, Lotta LA, Musser BJ, Mastaitis J, Devalaraja-Narashimha KB, Rankin AJ, Huang T, Herman G, Olson W, Murphy AJ, Yancopoulos GD, Olenchock BA, Morton L
Nature (2024) 633 pp. 654-661 [ DOI: doi:10.1038/s41586-024-07903-1 Pubmed: 39261724 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Atrial natriuretic peptide (3 kDa, Protein from Homo sapiens)
- Active complex of npr1 ectodomain, anp, and regn5381 fab (Complex from Homo sapiens)
- Atrial natriuretic peptide receptor 1 (52 kDa, Protein from Homo sapiens)
- Regn5381 fab light chain (23 kDa, Protein from Mus musculus)
- Regn5381 fab heavy chain (24 kDa, Protein from Mus musculus)
Complex of NPR1 ectodomain and REGN5381 Fab in an active-like state with no ANP bound
Resolution: 3.65 Å
EM Method: Single-particle
Fitted PDBs: 8tga
Q-score: 0.117
Dunn ME, Kithcart A, Kim JH, Ho AJ, Franklin MC, Romero Hernandez A, de Hoon J, Botermans W, Meyer J, Jin X, Zhang D, Torello J, Jasewicz D, Kamat V, Garnova E, Liu N, Rosconi M, Pan H, Karnik S, Burczynski ME, Zheng W, Rafique A, Nielsen JB, De T, Verweij N, Pandit A, Locke A, Chalasani N, Melander O, Schwantes-An TH, Baras A, Lotta LA, Musser BJ, Mastaitis J, Devalaraja-Narashimha KB, Rankin AJ, Huang T, Herman G, Olson W, Murphy AJ, Yancopoulos GD, Olenchock BA, Morton L
Nature (2024) 633 pp. 654-661 [ DOI: doi:10.1038/s41586-024-07903-1 Pubmed: 39261724 ]
- Regn5381 fab light chain (23 kDa, Protein from Mus musculus)
- Active-like complex of npr1 ectodomain and regn5381 fab, with no anp present (Complex from Homo sapiens)
- Atrial natriuretic peptide receptor 1 (52 kDa, Protein from Homo sapiens)
- Regn5381 fab heavy chain (24 kDa, Protein from Mus musculus)
Local refinement of SARS-CoV-2 BA.2.86 Spike and XBB-7 Fab
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8qtd
Q-score: 0.454
Liu C, Zhou D, Dijokaite-Guraliuc A, Supasa P, Duyvesteyn HME, Ginn HM, Selvaraj M, Mentzer AJ, Das R, de Silva TI, Ritter TG, Plowright M, Newman TAH, Stafford L, Kronsteiner B, Temperton N, Lui Y, Fellermeyer M, Goulder P, Klenerman P, Dunachie SJ, Barton MI, Kutuzov MA, Dushek O, Fry EE, Mongkolsapaya J, Ren J, Stuart DI, Screaton GR
Cell Rep Med (2024) 5 pp. 101553-101553 [ Pubmed: 38723626 DOI: doi:10.1016/j.xcrm.2024.101553 ]
- Xbb-7 fab heavy chain (14 kDa, Protein from Homo sapiens)
- Spike glycoprotein,fibritin (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Xbb-7 fab (Complex from Homo sapiens)
- Ba-2.86 variant sars-cov2 s protein complexed with xbb-7 fab. (Complex)
- Ba.2.86 variant sars-cov2 s protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Xbb-7 fab light chain (10 kDa, Protein from Homo sapiens)
XBB-4 Fab in complex with SARS-CoV-2 BA.2.12.1 Spike Glycoprotein
Resolution: 3.41 Å
EM Method: Single-particle
Fitted PDBs: 8r8k
Q-score: 0.504
Liu C, Zhou D, Dijokaite-Guraliuc A, Supasa P, Duyvesteyn HME, Ginn HM, Selvaraj M, Mentzer AJ, Das R, de Silva TI, Ritter TG, Plowright M, Newman TAH, Stafford L, Kronsteiner B, Temperton N, Lui Y, Fellermeyer M, Goulder P, Klenerman P, Dunachie SJ, Barton MI, Kutuzov MA, Dushek O, Fry EE, Mongkolsapaya J, Ren J, Stuart DI, Screaton GR
Cell Rep Med (2024) 5 pp. 101553-101553 [ Pubmed: 38723626 DOI: doi:10.1016/j.xcrm.2024.101553 ]
- Xbb-4 fab light chain (23 kDa, Protein from Homo sapiens)
- Xbb-4 fab in complex with sars-cov-2 ba.2.12.1 spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein,fibritin (142 kDa, Protein from Tequatrovirus T4)
- Xbb-4 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Ba.2.12.1 spike glycoprotein ectodomain (Complex from Severe acute respiratory syndrome coronavirus 2)
- Xbb-4 fab (Complex from Homo sapiens)
SARS-CoV-2 Omicron Variant Spike Trimer in complex with three 17T2 Fabs
de Campos-Mata L, Trinite B, Modrego A, Tejedor Vaquero S, Pradenas E, Pons-Grifols A, Rodrigo Melero N, Carlero D, Marfil S, Santiago C, Raich-Regue D, Bueno-Carrasco MT, Tarres-Freixas F, Abanco F, Urrea V, Izquierdo-Useros N, Riveira-Munoz E, Ballana E, Perez M, Vergara-Alert J, Segales J, Carolis C, Arranz R, Blanco J, Magri G
Nat Commun (2024) 15 pp. 1051-1051 [ Pubmed: 38316751 DOI: doi:10.1038/s41467-024-45171-9 ]
- 17t2 fab light chain (Protein from Homo sapiens)
- Spike glycoprotein (Protein from Severe acute respiratory syndrome coronavirus)
- Sars-cov-2 omicron variant spike trimer in complex with three 17t2 fabs (Complex)
- 17t2 fab heavy chain (Protein from Homo sapiens)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus)
- 17t2 fab (Complex from Homo sapiens)
Resolution: 4.41 Å
EM Method: Single-particle
Fitted PDBs: 8c89
Q-score: 0.131
de Campos-Mata L, Trinite B, Modrego A, Tejedor Vaquero S, Pradenas E, Pons-Grifols A, Rodrigo Melero N, Carlero D, Marfil S, Santiago C, Raich-Regue D, Bueno-Carrasco MT, Tarres-Freixas F, Abanco F, Urrea V, Izquierdo-Useros N, Riveira-Munoz E, Ballana E, Perez M, Vergara-Alert J, Segales J, Carolis C, Arranz R, Blanco J, Magri G
Nat Commun (2024) 15 pp. 1051-1051 [ Pubmed: 38316751 DOI: doi:10.1038/s41467-024-45171-9 ]
- 17t2 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Sars-cov-2 omicron variant spike trimer in complex with three 17t2 fabs (Complex)
- Spike protein s2' (23 kDa, Protein from Severe acute respiratory syndrome coronavirus)
- 17t2 fab (Complex from Homo sapiens)
- 17t2 fab light chain (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein rbd (Complex from Severe acute respiratory syndrome coronavirus)