HIV-1 BG505 Env SOSIP in complex with bovine Fab Bess4 and non-human primate Fab RM20A3
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8tq1
Q-score: 0.512
Altman PX, Ozorowski G, Stanfield RL, Haakenson J, Appel M, Parren M, Lee WH, Sang H, Woehl J, Saye-Francisco K, Sewall LM, Joyce C, Song G, Porter K, Landais E, Andrabi R, Wilson IA, Ward AB, Mwangi W, Smider VV, Burton DR, Sok D
PLoS Pathog (2024) 20 pp. e1012042-e1012042 [ DOI: doi:10.1371/journal.ppat.1012042 Pubmed: 39250525 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Nhp rm20a3 fab heavy chain (13 kDa, Protein from Macaca mulatta)
- Bovine bess4 fab heavy chain (17 kDa, Protein from Bos taurus)
- Transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 envelope glycoprotein bg505 sosip.664 gp120 (57 kDa, Protein from Human immunodeficiency virus 1)
- Nhp rm20a3 fab light chain (13 kDa, Protein from Macaca mulatta)
- Hiv-1 bg505 sosip env in complex with bovine bess4 fab and nhp rm20a3 fab (Complex from Human immunodeficiency virus 1)
CCHFV GP38 bound with ADI-46143 and ADI-46158 Fabs
Shin OS, Monticelli SR, Hjorth CK, Hornet V, Doyle M, Abelson D, Kuehne AI, Wang A, Bakken RR, Mishra AK, Middlecamp M, Champney E, Stuart L, Maurer DP, Li J, Berrigan J, Barajas J, Balinandi S, Lutwama JJ, Lobel L, Zeitlin L, Walker LM, Dye JM, Chandran K, Herbert AS, Pauli NT, McLellan JS
Cell Rep (2024) 43 pp. 114502-114502 [ Pubmed: 39002130 DOI: doi:10.1016/j.celrep.2024.114502 ]
- Cchfv gp38 bound with adi-46143 fab and adi-46158 fab (Complex)
- Adi-46158 fab light chain (Protein from Homo sapiens)
- Adi-46143 fab (Complex from Homo sapiens)
- Adi-46143 fab heavy chain (Protein from Homo sapiens)
- Cchfv gp38 (Protein from Crimean-Congo hemorrhagic fever virus)
- Adi-46143 fab light chain (Protein from Homo sapiens)
- Adi-46158 fab heavy chain (Protein from Homo sapiens)
- Cchfv gp38 (Complex from Crimean-Congo hemorrhagic fever virus)
- Adi-46158 fab (Complex from Homo sapiens)
CCHFV GP38 bound with ADI-58062 and ADI-63530 Fabs
Shin OS, Monticelli SR, Hjorth CK, Hornet V, Doyle M, Abelson D, Kuehne AI, Wang A, Bakken RR, Mishra AK, Middlecamp M, Champney E, Stuart L, Maurer DP, Li J, Berrigan J, Barajas J, Balinandi S, Lutwama JJ, Lobel L, Zeitlin L, Walker LM, Dye JM, Chandran K, Herbert AS, Pauli NT, McLellan JS
Cell Rep (2024) 43 pp. 114502-114502 [ Pubmed: 39002130 DOI: doi:10.1016/j.celrep.2024.114502 ]
- Cchfv gp38 bound with adi-58062 fab and adi-63530 fab (Complex)
- Adi-63530 fab (Complex from Homo sapiens)
- Adi-63530 fab light chain (Protein from Homo sapiens)
- Adi-63530 fab heavy chain (Protein from Homo sapiens)
- Cchfv gp38 (Protein from Crimean-Congo hemorrhagic fever virus)
- Adi-58062 fab heavy chain (Protein from Homo sapiens)
- Cchfv gp38 (Complex from Crimean-Congo hemorrhagic fever virus)
- Adi-58062 fab light chain (Protein from Homo sapiens)
- Adi-58062 fab (Complex from Homo sapiens)
CCHFV GP38 bound with ADI-58026 and ADI-63547 Fabs
Shin OS, Monticelli SR, Hjorth CK, Hornet V, Doyle M, Abelson D, Kuehne AI, Wang A, Bakken RR, Mishra AK, Middlecamp M, Champney E, Stuart L, Maurer DP, Li J, Berrigan J, Barajas J, Balinandi S, Lutwama JJ, Lobel L, Zeitlin L, Walker LM, Dye JM, Chandran K, Herbert AS, Pauli NT, McLellan JS
Cell Rep (2024) 43 pp. 114502-114502 [ Pubmed: 39002130 DOI: doi:10.1016/j.celrep.2024.114502 ]
- Adi-63547 fab (Complex from Homo sapiens)
- Adi-58026 fab heavy chain (Protein from Homo sapiens)
- Adi-58026 fab (Complex from Homo sapiens)
- Adi-63547 fab light chain (Protein from Homo sapiens)
- Cchfv gp38 bound with adi-58026 fab and adi-63547 fab (Complex)
- Adi-63547 fab heavy chain (Protein from Homo sapiens)
- Adi-58026 fab light chain (Protein from Homo sapiens)
- Cchfv gp38 (Protein from Crimean-Congo hemorrhagic fever virus)
- Cchfv gp38 (Complex from Crimean-Congo hemorrhagic fever virus)
CCHFV GP38 bound to ADI-46152 and ADI-58048 Fabs
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8vww
Q-score: 0.412
Shin OS, Monticelli SR, Hjorth CK, Hornet V, Doyle M, Abelson D, Kuehne AI, Wang A, Bakken RR, Mishra AK, Middlecamp M, Champney E, Stuart L, Maurer DP, Li J, Berrigan J, Barajas J, Balinandi S, Lutwama JJ, Lobel L, Zeitlin L, Walker LM, Dye JM, Chandran K, Herbert AS, Pauli NT, McLellan JS
Cell Rep (2024) 43 pp. 114502-114502 [ Pubmed: 39002130 DOI: doi:10.1016/j.celrep.2024.114502 ]
- Adi-46152 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Adi-58048 fab light chain (23 kDa, Protein from Homo sapiens)
- Gp38 (30 kDa, Protein from Crimean-Congo hemorrhagic fever virus strain IbAr10200)
- Adi-46152 fab (Complex from Homo sapiens)
- Adi-58048 fab heavy chain (23 kDa, Protein from Homo sapiens)
- Adi-46152 fab light chain (22 kDa, Protein from Homo sapiens)
- Adi-58048 fab (Complex from Homo sapiens)
- Cchfv gp38 (Complex from Crimean-Congo hemorrhagic fever virus)
- Cchfv gp38 bound with adi-46152 and adi-58048 fabs (Complex)
Structure of AT118-H Nanobody Antagonist in Complex with the Angiotensin II Type I Receptor
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8th3
Q-score: 0.532
Skiba MA, Sterling SM, Rawson S, Zhang S, Xu H, Jiang H, Nemeth GR, Gilman MSA, Hurley JD, Shen P, Staus DP, Kim J, McMahon C, Lehtinen MK, Rockman HA, Barth P, Wingler LM, Kruse AC
Nat Chem Biol (2024) 20 pp. 1577-1585 [ Pubmed: 38744986 DOI: doi:10.1038/s41589-024-01620-6 ]
- At118-h nanobody antagonist in complex with the angiotensin ii type i receptor bril fusion, anti-bril fab, and anti-fab nanobody (Complex from Homo sapiens)
- Bag2 anti-bril fab heavy chain (24 kDa, Protein from synthetic construct)
- At118-h nanobody, type-1 angiotensin ii receptor, soluble cytochrome b562 complex (65 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Bag2 anti-bril fab light chain (23 kDa, Protein from synthetic construct)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8th4
Q-score: 0.495
Skiba MA, Sterling SM, Rawson S, Zhang S, Xu H, Jiang H, Nemeth GR, Gilman MSA, Hurley JD, Shen P, Staus DP, Kim J, McMahon C, Lehtinen MK, Rockman HA, Barth P, Wingler LM, Kruse AC
Nat Chem Biol (2024) 20 pp. 1577-1585 [ Pubmed: 38744986 DOI: doi:10.1038/s41589-024-01620-6 ]
- Bag2 anti-bril fab heavy chain (24 kDa, Protein from synthetic construct)
- Type-1 angiotensin ii receptor soluble cytochrome b562 complex (49 kDa, Protein from Homo sapiens)
- At118-l nanobody antagonist in complex with the angiotensin ii type i receptor bril fusion protein, anti-bril fab, anti-fab nanobody, and losartan (Complex from Homo sapiens)
- [2-butyl-5-chloranyl-3-[[4-[2-(2h-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol (422 Da, Ligand)
- At118-l nanobody (15 kDa, Protein from synthetic construct)
- Bag2 anti-bril fab light chain (23 kDa, Protein from synthetic construct)
cryo-EM structure of BG505 SOSIP.664 HIV-1 Env trimer in complex with bNAbs EPTC112 and 3BNC117
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8c8t
Q-score: 0.511
Molinos-Albert LM, Baquero E, Bouvin-Pley M, Lorin V, Charre C, Planchais C, Dimitrov JD, Monceaux V, Vos M, Hocqueloux L, Berger JL, Seaman MS, Braibant M, Avettand-Fenoel V, Saez-Cirion A, Mouquet H
Cell Host Microbe (2023) 31 pp. 1275- [ DOI: doi:10.1016/j.chom.2023.06.006 Pubmed: 37433296 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Igg 3bnc117 fab light chain (23 kDa, Protein from Homo sapiens)
- Ternary complex of bg505 sosip.664 hiv-1 env with bnabs eptc112 and 3bnc117 (Complex from Homo sapiens)
- Envelope glycoprotein gp160 (52 kDa, Protein from Human immunodeficiency virus 1)
- Gp41 bg505 t332n sosip.664 (16 kDa, Protein from Human immunodeficiency virus 1)
- Igg 3bnc117 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Igg eptc112 fab light chain (22 kDa, Protein from Homo sapiens)
- Igg eptc112 fab fragment heavy chain (25 kDa, Protein from Homo sapiens)
Cryo-EM structure of Human respiratory syncytial virus F variant (construct pXCS847A)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7uja
Q-score: 0.492
Che Y, Gribenko AV, Song X, Handke LD, Efferen KS, Tompkins K, Kodali S, Nunez L, Prasad AK, Phelan LM, Ammirati M, Yu X, Lees JA, Chen W, Martinez L, Roopchand V, Han S, Qiu X, DeVincenzo JP, Jansen KU, Dormitzer PR, Swanson KA
Sci Transl Med (2023) 15 pp. eade6422-eade6422 [ Pubmed: 37023209 DOI: doi:10.1126/scitranslmed.ade6422 ]
- Human respiratory syncytial virus f variant (construct pxcs847a) with fabs am14 and am22 (Complex from Respiratory syncytial virus)
- Am14 fab light chain (23 kDa, Protein from Mus musculus)
- Am22 fab heavy chain (25 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Am14 fab heavy chain (26 kDa, Protein from Mus musculus)
- Rsv variant (construct pxcs847a) f2 (12 kDa, Protein from Respiratory syncytial virus)
- Am22 fab light chain (23 kDa, Protein from Mus musculus)
- Rsv variant (construct pxcs847a) f1 (45 kDa, Protein from Respiratory syncytial virus)
SARS-CoV-2 Delta Spike in complex with FP-12A
Resolution: 3.62 Å
EM Method: Single-particle
Fitted PDBs: 8hhx
Q-score: 0.301
Huang KA, Chen X, Mohapatra A, Nguyen HTV, Schimanski L, Tan TK, Rijal P, Vester SK, Hills RA, Howarth M, Keeffe JR, Cohen AA, Kakutani LM, Wu YM, Shahed-Al-Mahmud M, Chou YC, Bjorkman PJ, Townsend AR, Ma C
Nat Commun (2023) 14 pp. 311-311 [ Pubmed: 36658148 DOI: doi:10.1038/s41467-023-35949-8 ]
- Complex of delta spike and fp-12a with two fabs bound to one spike in 3-rbd-up conformation (550 kDa, Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 delta spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Fp-12a fab heavy chain (23 kDa, Protein from Homo sapiens)
- Fp-12a fab light chain (23 kDa, Protein from Homo sapiens)
- Fp-12a (Complex from Homo sapiens)