SARS-CoV-2 Spike S2 bound to Fab 54043-5
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8vcr
Q-score: 0.535
Johnson NV, Wall SC, Kramer KJ, Holt CM, Periasamy S, Richardson SI, Manamela NP, Suryadevara N, Andreano E, Paciello I, Pierleoni G, Piccini G, Huang Y, Ge P, Allen JD, Uno N, Shiakolas AR, Pilewski KA, Nargi RS, Sutton RE, Abu-Shmais AA, Parks R, Haynes BF, Carnahan RH, Crowe Jr JE, Montomoli E, Rappuoli R, Bukreyev A, Ross TM, Sautto GA, McLellan JS, Georgiev IS
Structure (2024) 32 pp. 1893- [ DOI: doi:10.1016/j.str.2024.08.022 Pubmed: 39326419 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- S2 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Fab 54043-5 (Complex from Homo sapiens)
- 54043-5 fab light chain (23 kDa, Protein from Homo sapiens)
- 54043-5 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Spike protein s2 (65 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Trimeric s2 bound to fab 54043-5 (Complex)
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus methaqualone
Resolution: 2.82 Å
EM Method: Single-particle
Fitted PDBs: 8vqy
Q-score: 0.557
Chojnacka W, Teng J, Kim JJ, Jensen AA, Hibbs RE
Nat Commun (2024) 15 pp. 5244-5244 [ Pubmed: 38898000 DOI: doi:10.1038/s41467-024-49471-y ]
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
- Phosphatidylethanolamine (734 Da, Ligand)
- O-[(r)-[(2s)-2-(hexadecanoyloxy)-3-(octadecanoyloxy)propoxy](hydroxy)phosphoryl]-d-serine (764 Da, Ligand)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- Human gabaa receptor alpha1-beta2-gamma2 subtype in complex with gaba plus methaqualone (368 kDa, Complex from Homo sapiens)
- 2-methyl-3-(2-methylphenyl)quinazolin-4(3h)-one (250 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus PPTQ
Resolution: 2.57 Å
EM Method: Single-particle
Fitted PDBs: 8vrn
Q-score: 0.618
Chojnacka W, Teng J, Kim JJ, Jensen AA, Hibbs RE
Nat Commun (2024) 15 pp. 5244-5244 [ Pubmed: 38898000 DOI: doi:10.1038/s41467-024-49471-y ]
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
- Phosphatidylethanolamine (734 Da, Ligand)
- O-[(r)-[(2s)-2-(hexadecanoyloxy)-3-(octadecanoyloxy)propoxy](hydroxy)phosphoryl]-d-serine (764 Da, Ligand)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- 3-(4-methylphenyl)-2-phenylquinazolin-4(3h)-one (312 Da, Ligand)
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- Human gabaa receptor alpha1-beta2-gamma2 subtype in complex with gaba plus pptq (368 kDa, Complex from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
BtCoV-422 in complex with neutralizing antibody JC57-11
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8sak
Q-score: 0.514
Tse LV, Hou YJ, McFadden E, Lee RE, Scobey TD, Leist SR, Martinez DR, Meganck RM, Schafer A, Yount BL, Mascenik T, Powers JM, Randell SH, Zhang Y, Wang L, Mascola J, McLellan JS, Baric RS
Sci Transl Med (2023) 15 pp. eadg5567-eadg5567 [ Pubmed: 37756379 DOI: doi:10.1126/scitranslmed.adg5567 ]
- Spike glycoprotein (142 kDa, Protein from unclassified Merbecovirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Btcov-422 spike (600 kDa, Complex from Middle East respiratory syndrome-related coronavirus)
- Jc57-11 fab light chain (23 kDa, Protein from Macaca)
- Jc57-11 fab heavy chain (25 kDa, Protein from Macaca)
- Jc57-11 fab (50 kDa, Complex from Macaca)
- Btcov-422 in complex with jc57-11 fab (650 kDa, Complex)
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus pregnenolone sulfate
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 8sgo
Q-score: 0.575
Legesse DH, Fan C, Teng J, Zhuang Y, Howard RJ, Noviello CM, Lindahl E, Hibbs RE
Nat Commun (2023) 14 pp. 5091-5091 [ Pubmed: 37607940 DOI: doi:10.1038/s41467-023-40800-1 ]
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
- Phosphatidylethanolamine (734 Da, Ligand)
- Pregnenolone sulfate (396 Da, Ligand)
- O-[(r)-[(2s)-2-(hexadecanoyloxy)-3-(octadecanoyloxy)propoxy](hydroxy)phosphoryl]-d-serine (764 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with gaba and pregnenolone sulfate (Complex from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus allopregnanolone
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8si9
Q-score: 0.524
Legesse DH, Fan C, Teng J, Zhuang Y, Howard RJ, Noviello CM, Lindahl E, Hibbs RE
Nat Commun (2023) 14 pp. 5091-5091 [ Pubmed: 37607940 DOI: doi:10.1038/s41467-023-40800-1 ]
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with gaba and allopregnanolone (Complex from Homo sapiens)
- Allopregnanolone (318 Da, Ligand)
Resolution: 2.71 Å
EM Method: Single-particle
Fitted PDBs: 8sid
Q-score: 0.539
Legesse DH, Fan C, Teng J, Zhuang Y, Howard RJ, Noviello CM, Lindahl E, Hibbs RE
Nat Commun (2023) 14 pp. 5091-5091 [ Pubmed: 37607940 DOI: doi:10.1038/s41467-023-40800-1 ]
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
- Phosphatidylethanolamine (734 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
- O-[(r)-[(2s)-2-(hexadecanoyloxy)-3-(octadecanoyloxy)propoxy](hydroxy)phosphoryl]-d-serine (764 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with gaba and dehydroepiandrosterone sulfate (Complex from Homo sapiens)
- 17-oxoandrost-5-en-3beta-yl hydrogen sulfate (368 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Structure of dengue virus (DENV2) in complex with prM12, an anti-PrM monoclonal antibody
Resolution: 10.2 Å
EM Method: Single-particle
Fitted PDBs: 8fe3
Q-score: 0.059
A Dowd K, Sirohi D, D Speer S, VanBlargan LA, Chen RE, Mukherjee S, Whitener BM, Govero J, Aleshnick M, Larman B, Sukupolvi-Petty S, Sevvana M, Miller AS, Klose T, Zheng A, Koenig S, Kielian M, Kuhn RJ, Diamond MS, Pierson TC
PNAS (2023) 120 pp. e2218899120-e2218899120 [ Pubmed: 36638211 DOI: doi:10.1073/pnas.2218899120 ]
- Envelope protein e (43 kDa, Protein from Dengue virus type 2)
- Dengue virus 2 (Virus from Dengue virus 2)
- Prm12 fab heavy chain (24 kDa, Protein from Mus musculus)
- Prm protein (9 kDa, Protein from Dengue virus type 2)
- Prm12 fab light chain (23 kDa, Protein from Mus musculus)
Structure of dengue virus (DENV2) in complex with prM13, an anti-PrM monoclonal antibody
Resolution: 9.8 Å
EM Method: Single-particle
Fitted PDBs: 8fe4
Q-score: 0.062
A Dowd K, Sirohi D, D Speer S, VanBlargan LA, Chen RE, Mukherjee S, Whitener BM, Govero J, Aleshnick M, Larman B, Sukupolvi-Petty S, Sevvana M, Miller AS, Klose T, Zheng A, Koenig S, Kielian M, Kuhn RJ, Diamond MS, Pierson TC
PNAS (2023) 120 pp. e2218899120-e2218899120 [ Pubmed: 36638211 DOI: doi:10.1073/pnas.2218899120 ]
- Envelope protein e (43 kDa, Protein from Dengue virus type 2)
- Dengue virus 2 (Virus from Dengue virus 2)
- Prm13 fab heavy chain (23 kDa, Protein from Mus musculus)
- Prm13 fab light chain (23 kDa, Protein from Mus musculus)
- Prm protein (9 kDa, Protein from Dengue virus type 2)
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus Zolpidem
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8dd2
Q-score: 0.566
Zhu S, Sridhar A, Teng J, Howard RJ, Lindahl E, Hibbs RE
Nat Commun (2022) 13 pp. 4582-4582 [ Pubmed: 35933426 DOI: doi:10.1038/s41467-022-32212-4 ]
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Human gabaa receptor alpha1-beta2-gamma2 subtype in complex with gaba plus zolpidem (Complex from Mus musculus)
- Zolpidem (307 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)