SARS-CoV-2 Spike S2 bound to Fab 54043-5
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8vcr
Q-score: 0.535
Johnson NV, Wall SC, Kramer KJ, Holt CM, Periasamy S, Richardson SI, Manamela NP, Suryadevara N, Andreano E, Paciello I, Pierleoni G, Piccini G, Huang Y, Ge P, Allen JD, Uno N, Shiakolas AR, Pilewski KA, Nargi RS, Sutton RE, Abu-Shmais AA, Parks R, Haynes BF, Carnahan RH, Crowe Jr JE, Montomoli E, Rappuoli R, Bukreyev A, Ross TM, Sautto GA, McLellan JS, Georgiev IS
Structure (2024) 32 pp. 1893- [ Pubmed: 39326419 DOI: doi:10.1016/j.str.2024.08.022 ]
- S2 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike protein s2 (65 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Fab 54043-5 (Complex from Homo sapiens)
- 54043-5 fab light chain (23 kDa, Protein from Homo sapiens)
- Trimeric s2 bound to fab 54043-5 (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 54043-5 fab heavy chain (25 kDa, Protein from Homo sapiens)
BtCoV-422 in complex with neutralizing antibody JC57-11
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8sak
Q-score: 0.514
Tse LV, Hou YJ, McFadden E, Lee RE, Scobey TD, Leist SR, Martinez DR, Meganck RM, Schafer A, Yount BL, Mascenik T, Powers JM, Randell SH, Zhang Y, Wang L, Mascola J, McLellan JS, Baric RS
Sci Transl Med (2023) 15 pp. eadg5567-eadg5567 [ DOI: doi:10.1126/scitranslmed.adg5567 Pubmed: 37756379 ]
- Btcov-422 spike (600 kDa, Complex from Middle East respiratory syndrome-related coronavirus)
- Jc57-11 fab heavy chain (25 kDa, Protein from Macaca)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Btcov-422 in complex with jc57-11 fab (650 kDa, Complex)
- Spike glycoprotein (142 kDa, Protein from unclassified Merbecovirus)
- Jc57-11 fab light chain (23 kDa, Protein from Macaca)
- Jc57-11 fab (50 kDa, Complex from Macaca)
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus pregnenolone sulfate
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 8sgo
Q-score: 0.575
Legesse DH, Fan C, Teng J, Zhuang Y, Howard RJ, Noviello CM, Lindahl E, Hibbs RE
Nat Commun (2023) 14 pp. 5091-5091 [ Pubmed: 37607940 DOI: doi:10.1038/s41467-023-40800-1 ]
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
- Pregnenolone sulfate (396 Da, Ligand)
- O-[(r)-[(2s)-2-(hexadecanoyloxy)-3-(octadecanoyloxy)propoxy](hydroxy)phosphoryl]-d-serine (764 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
- Phosphatidylethanolamine (734 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with gaba and pregnenolone sulfate (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus allopregnanolone
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8si9
Q-score: 0.524
Legesse DH, Fan C, Teng J, Zhuang Y, Howard RJ, Noviello CM, Lindahl E, Hibbs RE
Nat Commun (2023) 14 pp. 5091-5091 [ Pubmed: 37607940 DOI: doi:10.1038/s41467-023-40800-1 ]
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with gaba and allopregnanolone (Complex from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
- Allopregnanolone (318 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 2.71 Å
EM Method: Single-particle
Fitted PDBs: 8sid
Q-score: 0.539
Legesse DH, Fan C, Teng J, Zhuang Y, Howard RJ, Noviello CM, Lindahl E, Hibbs RE
Nat Commun (2023) 14 pp. 5091-5091 [ Pubmed: 37607940 DOI: doi:10.1038/s41467-023-40800-1 ]
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
- O-[(r)-[(2s)-2-(hexadecanoyloxy)-3-(octadecanoyloxy)propoxy](hydroxy)phosphoryl]-d-serine (764 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with gaba and dehydroepiandrosterone sulfate (Complex from Homo sapiens)
- Phosphatidylethanolamine (734 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- 17-oxoandrost-5-en-3beta-yl hydrogen sulfate (368 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus Zolpidem
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8dd2
Q-score: 0.566
Zhu S, Sridhar A, Teng J, Howard RJ, Lindahl E, Hibbs RE
Nat Commun (2022) 13 pp. 4582-4582 [ DOI: doi:10.1038/s41467-022-32212-4 Pubmed: 35933426 ]
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Zolpidem (307 Da, Ligand)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Human gabaa receptor alpha1-beta2-gamma2 subtype in complex with gaba plus zolpidem (Complex from Mus musculus)
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus DMCM
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8dd3
Q-score: 0.549
Zhu S, Sridhar A, Teng J, Howard RJ, Lindahl E, Hibbs RE
Nat Commun (2022) 13 pp. 4582-4582 [ DOI: doi:10.1038/s41467-022-32212-4 Pubmed: 35933426 ]
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Human gabaa receptor alpha1-beta2-gamma2 subtype in complex with gaba plus dmcm (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Methyl 4-ethyl-6,7-dimethoxy-9h-pyrido[3,4-b]indole-3-carboxylate (314 Da, Ligand)
SARS-CoV-2 S-RBD + Fab 54042-4
Resolution: 2.69 Å
EM Method: Single-particle
Fitted PDBs: 7t01
Q-score: 0.463
Kramer KJ, Johnson NV, Shiakolas AR, Suryadevara N, Periasamy S, Raju N, Williams JK, Wrapp D, Zost SJ, Walker LM, Wall SC, Holt CM, Hsieh CL, Sutton RE, Paulo A, Nargi RS, Davidson E, Doranz BJ, Crowe Jr JE, Bukreyev A, Carnahan RH, McLellan JS, Georgiev IS
Cell Rep (2021) 37 pp. 109784-109784 [ DOI: doi:10.1016/j.celrep.2021.109784 Pubmed: 34592170 ]
- 54042-4 fab - heavy chain (13 kDa, Protein from Homo sapiens)
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 54042-4 fab - light chain (11 kDa, Protein from Homo sapiens)
- Complex of sars-cov-2 s-ecd with 54042-4 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV 2 Spike Protein bound to LY-CoV555
Resolution: 3.27 Å
EM Method: Single-particle
Fitted PDBs: 7l3n
Q-score: 0.361
Jones BE, Brown-Augsburger PL, Corbett KS, Westendorf K, Davies J, Cujec TP, Wiethoff CM, Blackbourne JL, Heinz BA, Foster D, Higgs RE, Balasubramaniam D, Wang L, Bidshahri R, Kraft L, Hwang Y, Zentelis S, Jepson KR, Goya R, Smith MA, Collins DW, Hinshaw SJ, Tycho SA, Pellacani D, Xiang P, Muthuraman K, Sobhanifar S, Piper MH, Triana FJ, Hendle J, Pustilnik A, Adams AC, Berens SJ, Baric RS, Martinez DR, Cross RW, Geisbert TW, Borisevich V, Abiona O, Belli HM, de Vries M, Mohamed A, Dittmann M, Samanovic M, Mulligan MJ, Goldsmith JA, Hsieh CL, Johnson NV, Wrapp D, McLellan JS, Barnhart BC, Graham BS, Mascola JR, Hansen CL, Falconer E
bioRxiv (2020) [ DOI: doi:10.1101/2020.09.30.318972 Pubmed: 33024963 ]
- Sars-cov-2 spike protein bound to neutralizing antibody ly-cov555 (Complex)
- Ly-cov555 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Ly-cov555 fab light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Neutralizing antibody ly-cov555 (Complex from Homo sapiens)
CryoEM structure of Eastern Equine Encephalitis (EEEV) VLP with Fab EEEV-143.
Resolution: 8.5 Å
EM Method: Single-particle
Fitted PDBs: 6xob
Q-score: 0.182
Williamson LE, Gilliland Jr T, Yadav PK, Binshtein E, Bombardi R, Kose N, Nargi RS, Sutton RE, Durie CL, Armstrong E, Carnahan RH, Walker LM, Kim AS, Fox JM, Diamond MS, Ohi MD, Klimstra WB, Crowe Jr JE
Cell (2020) 183 pp. 1884-1900.e23 [ Pubmed: 33301709 DOI: doi:10.1016/j.cell.2020.11.011 ]
- Togavirin (47 kDa, Protein from Eastern equine encephalitis virus)
- Eeev-143 fab heavy chain (23 kDa, Protein from Homo sapiens)
- Togavirin (29 kDa, Protein from Eastern equine encephalitis virus)
- Togavirin (47 kDa, Protein from Eastern equine encephalitis virus)
- Eastern equine encephalitis virus (Virus from Eastern equine encephalitis virus)
- Eeev-143 fab light chain (23 kDa, Protein from Homo sapiens)