Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus pregnenolone sulfate
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 8sgo
Q-score: 0.575
Legesse DH, Fan C, Teng J, Zhuang Y, Howard RJ, Noviello CM, Lindahl E, Hibbs RE
Nat Commun (2023) 14 pp. 5091-5091 [ Pubmed: 37607940 DOI: doi:10.1038/s41467-023-40800-1 ]
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
- Pregnenolone sulfate (396 Da, Ligand)
- O-[(r)-[(2s)-2-(hexadecanoyloxy)-3-(octadecanoyloxy)propoxy](hydroxy)phosphoryl]-d-serine (764 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
- Phosphatidylethanolamine (734 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with gaba and pregnenolone sulfate (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus allopregnanolone
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8si9
Q-score: 0.524
Legesse DH, Fan C, Teng J, Zhuang Y, Howard RJ, Noviello CM, Lindahl E, Hibbs RE
Nat Commun (2023) 14 pp. 5091-5091 [ Pubmed: 37607940 DOI: doi:10.1038/s41467-023-40800-1 ]
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with gaba and allopregnanolone (Complex from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
- Allopregnanolone (318 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 2.71 Å
EM Method: Single-particle
Fitted PDBs: 8sid
Q-score: 0.539
Legesse DH, Fan C, Teng J, Zhuang Y, Howard RJ, Noviello CM, Lindahl E, Hibbs RE
Nat Commun (2023) 14 pp. 5091-5091 [ Pubmed: 37607940 DOI: doi:10.1038/s41467-023-40800-1 ]
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
- O-[(r)-[(2s)-2-(hexadecanoyloxy)-3-(octadecanoyloxy)propoxy](hydroxy)phosphoryl]-d-serine (764 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with gaba and dehydroepiandrosterone sulfate (Complex from Homo sapiens)
- Phosphatidylethanolamine (734 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- 17-oxoandrost-5-en-3beta-yl hydrogen sulfate (368 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of dengue virus (DENV2) in complex with prM12, an anti-PrM monoclonal antibody
Resolution: 10.2 Å
EM Method: Single-particle
Fitted PDBs: 8fe3
Q-score: 0.059
A Dowd K, Sirohi D, D Speer S, VanBlargan LA, Chen RE, Mukherjee S, Whitener BM, Govero J, Aleshnick M, Larman B, Sukupolvi-Petty S, Sevvana M, Miller AS, Klose T, Zheng A, Koenig S, Kielian M, Kuhn RJ, Diamond MS, Pierson TC
PNAS (2023) 120 pp. e2218899120-e2218899120 [ Pubmed: 36638211 DOI: doi:10.1073/pnas.2218899120 ]
- Dengue virus 2 (Virus from Dengue virus 2)
- Prm12 fab heavy chain (24 kDa, Protein from Mus musculus)
- Envelope protein e (43 kDa, Protein from Dengue virus type 2)
- Prm12 fab light chain (23 kDa, Protein from Mus musculus)
- Prm protein (9 kDa, Protein from Dengue virus type 2)
Structure of dengue virus (DENV2) in complex with prM13, an anti-PrM monoclonal antibody
Resolution: 9.8 Å
EM Method: Single-particle
Fitted PDBs: 8fe4
Q-score: 0.062
A Dowd K, Sirohi D, D Speer S, VanBlargan LA, Chen RE, Mukherjee S, Whitener BM, Govero J, Aleshnick M, Larman B, Sukupolvi-Petty S, Sevvana M, Miller AS, Klose T, Zheng A, Koenig S, Kielian M, Kuhn RJ, Diamond MS, Pierson TC
PNAS (2023) 120 pp. e2218899120-e2218899120 [ Pubmed: 36638211 DOI: doi:10.1073/pnas.2218899120 ]
- Dengue virus 2 (Virus from Dengue virus 2)
- Prm13 fab light chain (23 kDa, Protein from Mus musculus)
- Prm13 fab heavy chain (23 kDa, Protein from Mus musculus)
- Envelope protein e (43 kDa, Protein from Dengue virus type 2)
- Prm protein (9 kDa, Protein from Dengue virus type 2)
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus Zolpidem
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8dd2
Q-score: 0.566
Zhu S, Sridhar A, Teng J, Howard RJ, Lindahl E, Hibbs RE
Nat Commun (2022) 13 pp. 4582-4582 [ DOI: doi:10.1038/s41467-022-32212-4 Pubmed: 35933426 ]
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Zolpidem (307 Da, Ligand)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Human gabaa receptor alpha1-beta2-gamma2 subtype in complex with gaba plus zolpidem (Complex from Mus musculus)
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus DMCM
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8dd3
Q-score: 0.549
Zhu S, Sridhar A, Teng J, Howard RJ, Lindahl E, Hibbs RE
Nat Commun (2022) 13 pp. 4582-4582 [ DOI: doi:10.1038/s41467-022-32212-4 Pubmed: 35933426 ]
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Human gabaa receptor alpha1-beta2-gamma2 subtype in complex with gaba plus dmcm (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Methyl 4-ethyl-6,7-dimethoxy-9h-pyrido[3,4-b]indole-3-carboxylate (314 Da, Ligand)
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with bicuculline methbromide
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 6x3s
Q-score: 0.531
Kim JJ, Gharpure A, Teng J, Zhuang Y, Howard RJ, Zhu S, Noviello CM, Walsh Jr RM, Lindahl E, Hibbs RE
Nature (2020) 585 pp. 303-308 [ DOI: doi:10.1038/s41586-020-2654-5 Pubmed: 32879488 ]
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
- (5s)-6,6-dimethyl-5-[(6r)-8-oxo-6,8-dihydrofuro[3,4-e][1,3]benzodioxol-6-yl]-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-6-ium (382 Da, Ligand)
- Alpha-d-mannopyranose (180 Da, Ligand)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with bicuculline (Complex from Homo sapiens)
- Gamma-aminobutyric acid type a receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype (Complex from Homo sapiens)
- Igg2b/kappa antibody (Complex from Mus musculus)
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus propofol
Resolution: 2.55 Å
EM Method: Single-particle
Fitted PDBs: 6x3t
Q-score: 0.642
Kim JJ, Gharpure A, Teng J, Zhuang Y, Howard RJ, Zhu S, Noviello CM, Walsh Jr RM, Lindahl E, Hibbs RE
Nature (2020) 585 pp. 303-308 [ DOI: doi:10.1038/s41586-020-2654-5 Pubmed: 32879488 ]
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
- 2,6-bis(1-methylethyl)phenol (178 Da, Ligand)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with gaba and propofol (Complex from Homo sapiens)
- Gamma-aminobutyric acid type a receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype (Complex from Homo sapiens)
- Igg2b/kappa antibody (Complex from Mus musculus)
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus flumazenil
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6x3u
Q-score: 0.462
Kim JJ, Gharpure A, Teng J, Zhuang Y, Howard RJ, Zhu S, Noviello CM, Walsh Jr RM, Lindahl E, Hibbs RE
Nature (2020) 585 pp. 303-308 [ DOI: doi:10.1038/s41586-020-2654-5 Pubmed: 32879488 ]
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
- Ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4h-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate (303 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Igg2b/kappa antibody (Complex from Mus musculus)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype (Complex from Homo sapiens)
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with gaba and flumazenil (Complex)