SFTSV Gn in complex with JK-8/12 Fab
Resolution: 2.37 Å
EM Method: Single-particle
Fitted PDBs: 8zhq
Q-score: 0.505
Zhang S, Shang H, Han S, Li J, Peng X, Wu Y, Yang X, Leng Y, Wang F, Cui N, Xu L, Zhang H, Guo Y, Xu X, Zhang N, Liu W, Li H
Ebiomedicine (2024) 111 pp. 105481-105481 [ Pubmed: 39644769 DOI: doi:10.1016/j.ebiom.2024.105481 ]
- Envelopment polyprotein (38 kDa, Protein from Severe fever with thrombocytopenia syndrome virus)
- Jk-8 fab heavy chain (23 kDa, Protein from Homo sapiens)
- Jk-8 fab light chain (23 kDa, Protein from Homo sapiens)
- Jk-12 fab light chain (22 kDa, Protein from Homo sapiens)
- Jk-12 fab heavy chain (22 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ternary complex of sftsv gn with neutralizing antibodies fab jk-8 and jk-12 (150 kDa, Complex from Homo sapiens)
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 9c44
Q-score: 0.535
Liu P, Huang ML, Guo H, McCallum M, Si JY, Chen YM, Wang CL, Yu X, Shi LL, Xiong Q, Ma CB, Bowen JE, Tong F, Liu C, Sun YH, Yang X, Chen J, Guo M, Li J, Corti D, Veesler D, Shi ZL, Yan H
Nature (2024) 635 pp. 978-986 [ DOI: doi:10.1038/s41586-024-08121-5 Pubmed: 39478224 ]
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- S2l20 fab light chain variable region (11 kDa, Protein from Homo sapiens)
- Sars-cov-2 s bound by s2l20 fab (Complex from Homo sapiens)
- S2l20 fab heavy chain variable (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
SARS-CoV-2 S + S2L20 (local refinement of NTD and S2L20 Fab variable region)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 9c45
Q-score: 0.552
Liu P, Huang ML, Guo H, McCallum M, Si JY, Chen YM, Wang CL, Yu X, Shi LL, Xiong Q, Ma CB, Bowen JE, Tong F, Liu C, Sun YH, Yang X, Chen J, Guo M, Li J, Corti D, Veesler D, Shi ZL, Yan H
Nature (2024) 635 pp. 978-986 [ DOI: doi:10.1038/s41586-024-08121-5 Pubmed: 39478224 ]
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- S2l20 fab light chain variable region (11 kDa, Protein from Homo sapiens)
- Sars-cov-2 s bound by s2l20 fab (Complex from Homo sapiens)
- S2l20 fab heavy chain variable (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 2.49 Å
EM Method: Single-particle
Fitted PDBs: 8wpw
Q-score: 0.542
Su C, He JH, Qi JX, Yang MS, Wang QH, Gao GF
To Be Published
- Cb6 fab mutant heavy chain (24 kDa, Protein from Homo sapiens)
- S304 fab heavy chain (24 kDa, Protein from Homo sapiens)
- S309 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Spike protein s1 (25 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Fab (Complex from Severe acute respiratory syndrome-related coronavirus)
- Cb6 fab mutant light chain (23 kDa, Protein from Homo sapiens)
- S304 fab light chain (23 kDa, Protein from Homo sapiens)
- S309 fab light chain (23 kDa, Protein from Homo sapiens)
- Cryo-em structure of sars-cov-2 xbb.1.5 receptor-binding domain (rbd) complexed with cb6 mutant,s309, and s304 antibodies (Complex from Homo sapiens)
- Sars-cov-2 xbb.1.5 rbd (Complex)
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 8wpy
Q-score: 0.488
Su C, He JH, Qi JX, Yang MS, Wang QH, Gao GF
To Be Published
- Cb6 fab mutant heavy chain (24 kDa, Protein from Homo sapiens)
- S304 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Spike protein s1 (25 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- S309 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Fab (Complex from Severe acute respiratory syndrome-related coronavirus)
- Cb6 fab mutant light chain (23 kDa, Protein from Homo sapiens)
- Cryo-em structure of sars-cov-2 receptor-binding domain (rbd) complexed with cb6 mutant,s309, and s304 antibodies (Complex from Homo sapiens)
- S304 fab light chain (23 kDa, Protein from Homo sapiens)
- S309 fab light chain (23 kDa, Protein from Homo sapiens)
- Sars-cov-2 rbd (Complex)
Engineered peptide-specific binder in complex with HLA-DR1/CLIP
Resolution: 2.28 Å
EM Method: Single-particle
Fitted PDBs: 8vsj
Q-score: 0.528
Du H, Liu J, Jude KM, Yang X, Li Y, Bell B, Yang H, Kassardjian A, Blackson W, Mobedi A, Parekh U, Parra Sperberg RA, Julien JP, Mellins ED, Garcia KC, Huang PS
Nat Biotechnol (2024) [ Pubmed: 39672953 DOI: doi:10.1038/s41587-024-02466-y ]
- Hla class ii histocompatibility antigen, dr alpha chain (21 kDa, Protein from Homo sapiens)
- Engineered peptide-specific binder in complex with hla-dr1/clip (Complex from Homo sapiens)
- Hla class ii histocompatibility antigen dr beta chain (22 kDa, Protein from Homo sapiens)
- C44h10 fab light chain (23 kDa, Protein from Homo sapiens)
- C44h10 fab heavy chain (23 kDa, Protein from Homo sapiens)
- Superantigen (15 kDa, Protein from Metamycoplasma arthritidis)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Class-ii-associated invariant chain peptide (1 kDa, Protein from Homo sapiens)
Cryo-EM structure of ETAR bound with Macitentan
Hou J, Liu S, Zhang X, Tu G, Wu L, Zhang Y, Yang H, Li X, Liu J, Jiang L, Tan Q, Bai F, Liu Z, Miao C, Hua T, Luo Z
Cell Discov (2024) 10 pp. 79-79 [ DOI: doi:10.1038/s41421-024-00705-9 Pubmed: 39075075 ]
- Macitentan (588 Da, Ligand)
- Endoglucanase h,endothelin-1 receptor,soluble cytochrome b562 (89 kDa, Protein from Homo sapiens)
- Anti-bril fab light chain (25 kDa, Protein from Homo sapiens)
- Anti-fab nanobody (15 kDa, Protein from synthetic construct)
- Anti-bril fab heavy chain (28 kDa, Protein from Homo sapiens)
- Complex of endothelin receptor type a with macitentan (Complex from Homo sapiens)
Cryo-EM structure of ETAR bound with Ambrisentan
Hou J, Liu S, Zhang X, Tu G, Wu L, Zhang Y, Yang H, Li X, Liu J, Jiang L, Tan Q, Bai F, Liu Z, Miao C, Hua T, Luo Z
Cell Discov (2024) 10 pp. 79-79 [ DOI: doi:10.1038/s41421-024-00705-9 Pubmed: 39075075 ]
- Complex of endothelin receptor type a with ambrisentan (Complex from Homo sapiens)
- Endoglucanase h,endothelin-1 receptor,soluble cytochrome b562 (89 kDa, Protein from Homo sapiens)
- Anti-bril fab light chain (25 kDa, Protein from Homo sapiens)
- Anti-bril fab heavy chain (28 kDa, Protein from Homo sapiens)
- Anti-fab nanobody (15 kDa, Protein from synthetic construct)
- Ambrisentan (378 Da, Ligand)
Cryo-EM structure of ETAR bound with Zibotentan
Hou J, Liu S, Zhang X, Tu G, Wu L, Zhang Y, Yang H, Li X, Liu J, Jiang L, Tan Q, Bai F, Liu Z, Miao C, Hua T, Luo Z
Cell Discov (2024) 10 pp. 79-79 [ DOI: doi:10.1038/s41421-024-00705-9 Pubmed: 39075075 ]
- Zibotentan (424 Da, Ligand)
- Complex of endothelin receptor type a with zibotentan (Complex from Homo sapiens)
- Endoglucanase h,endothelin-1 receptor,soluble cytochrome b562 (89 kDa, Protein from Homo sapiens)
- Anti-bril fab light chain (25 kDa, Protein from Homo sapiens)
- Anti-bril fab heavy chain (28 kDa, Protein from Homo sapiens)
- Anti-fab nanobody (15 kDa, Protein from synthetic construct)
Cryo-EM structure of X6 COBRA (H1N1) hemagglutinin bound to CR6261 Fab
Resolution: 2.64 Å
EM Method: Single-particle
Fitted PDBs: 8f38
Q-score: 0.615
Nagashima KA, Dzimianski JV, Yang M, Abendroth J, Sautto GA, Ross TM, DuBois RM, Edwards TE, Mousa JJ
Structure (2024) 32 pp. 1079- [ Pubmed: 38810648 DOI: doi:10.1016/j.str.2024.05.001 ]
- Water (18 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cr6261 fab light chain (23 kDa, Protein from Homo sapiens)
- Hemagglutinin (63 kDa, Protein from synthetic construct)
- Cryo-em structure of x6 cobra (h1n1) hemagglutinin bound to cr6261 fab (450 kDa, Complex)
- Cr6261 fab heavy chain (24 kDa, Protein from Homo sapiens)