Integrin alpha-5 beta-1 in complex with BIIG2 Fab
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 9b9j
Q-score: 0.589
Nguyen A, Heim JB, Cordara G, Chan MC, Johannesen H, Charlesworth C, Li M, Azumaya CM, Madden B, Krengel U, Meves A, Campbell MG
bioRxiv (2025) [ DOI: doi:10.1101/2025.01.08.631572 Pubmed: 39829743 ]
- Integrin alpha-5 light chain (108 kDa, Protein from Homo sapiens)
- Biig2 fab light chain (23 kDa, Protein from Rattus norvegicus)
- Biig2 fab heavy chain (23 kDa, Protein from Rattus norvegicus)
- Integrin beta-1 (80 kDa, Protein from Homo sapiens)
- Protein complex of integrin alpha-5 beta-1 with biig2 fab (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Integrin alpha-5 beta-1 in complex with MINT1526A Fab
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 9b9k
Q-score: 0.547
Nguyen A, Heim JB, Cordara G, Chan MC, Johannesen H, Charlesworth C, Li M, Azumaya CM, Madden B, Krengel U, Meves A, Campbell MG
bioRxiv (2025) [ DOI: doi:10.1101/2025.01.08.631572 Pubmed: 39829743 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Integrin alpha-5 light chain (108 kDa, Protein from Homo sapiens)
- Mint1526a fab heavy chain (13 kDa, Protein from unidentified)
- Protein complex of integrin alpha-5 beta-1 with mint1526a fab (Complex from Homo sapiens)
- Integrin beta-1 (80 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Mint1526a fab light chain (11 kDa, Protein from unidentified)
The Cryo-EM structure of a complex between GAD65 and b96.11 Fab
Resolution: 7.3 Å
EM Method: Single-particle
Fitted PDBs: 7lz6
Q-score: 0.139
Stander SHD, Reboul CF, Le SN, Williams DE, Chandler PG, Costa MGS, Hoke DE, Jimma JDT, Fodor J, Fenalti G, Mannering SI, Porebski BT, Schofield P, Christ D, Buckle M, McGowan S, Elmlund D, Rand KD, Buckle AM
bioRxiv (2024) [ DOI: doi:10.1101/2024.03.18.585568 ]
- B96.11 fab light chain (23 kDa, Protein from Homo sapiens)
- Glutamate decarboxylase 2 (56 kDa, Protein from Homo sapiens)
- B96.11 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Gad65-b96.11 complex (Complex from Homo sapiens)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 9asd
Q-score: 0.506
Rosen LE, Tortorici MA, De Marco A, Pinto D, Foreman WB, Taylor AL, Park YJ, Bohan D, Rietz T, Errico JM, Hauser K, Dang HV, Chartron JW, Giurdanella M, Cusumano G, Saliba C, Zatta F, Sprouse KR, Addetia A, Zepeda SK, Brown J, Lee J, Dellota Jr E, Rajesh A, Noack J, Tao Q, DaCosta Y, Tsu B, Acosta R, Subramanian S, de Melo GD, Kergoat L, Zhang I, Liu Z, Guarino B, Schmid MA, Schnell G, Miller JL, Lempp FA, Czudnochowski N, Cameroni E, Whelan SPJ, Bourhy H, Purcell LA, Benigni F, di Iulio J, Pizzuto MS, Lanzavecchia A, Telenti A, Snell G, Corti D, Veesler D, Starr TN
Cell (2024) 187 pp. 7196- [ DOI: doi:10.1016/j.cell.2024.09.026 Pubmed: 39383863 ]
- Vir-7229 fab light chain (11 kDa, Protein from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Homo sapiens)
- Vir-7229 fab heavy chain (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ba 2.86 rbd - s2v29 complex (local refinement) (Complex from Sarbecovirus)
VIR-7229 Fab fragment bound the BA.2.86 spike trimer (global refinement)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9au2
Q-score: 0.499
Rosen LE, Tortorici MA, De Marco A, Pinto D, Foreman WB, Taylor AL, Park YJ, Bohan D, Rietz T, Errico JM, Hauser K, Dang HV, Chartron JW, Giurdanella M, Cusumano G, Saliba C, Zatta F, Sprouse KR, Addetia A, Zepeda SK, Brown J, Lee J, Dellota Jr E, Rajesh A, Noack J, Tao Q, DaCosta Y, Tsu B, Acosta R, Subramanian S, de Melo GD, Kergoat L, Zhang I, Liu Z, Guarino B, Schmid MA, Schnell G, Miller JL, Lempp FA, Czudnochowski N, Cameroni E, Whelan SPJ, Bourhy H, Purcell LA, Benigni F, di Iulio J, Pizzuto MS, Lanzavecchia A, Telenti A, Snell G, Corti D, Veesler D, Starr TN
Cell (2024) 187 pp. 7196- [ DOI: doi:10.1016/j.cell.2024.09.026 Pubmed: 39383863 ]
- Vir-7229 fab light chain (23 kDa, Protein from Homo sapiens)
- Vir-7229 fab heavy chain (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Ba.2.86 spike glycoprotein in complex with vir-7229 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of CCR6 bound by SQA1 and OXM2
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 9d3e
Q-score: 0.499
Wasilko DJ, Gerstenberger BS, Farley KA, Li W, Alley J, Schnute ME, Unwalla RJ, Victorino J, Crouse KK, Ding R, Sahasrabudhe PV, Vincent F, Frisbie RK, Dermenci A, Flick A, Choi C, Chinigo G, Mousseau JJ, Trujillo JI, Nuhant P, Mondal P, Lombardo V, Lamb D, Hogan BJ, Minhas GS, Segala E, Oswald C, Windsor IW, Han S, Rappas M, Cooke RM, Calabrese MF, Berstein G, Thorarensen A, Wu H
Nat Commun (2024) 15 pp. 7574-7574 [ DOI: doi:10.1038/s41467-024-52045-7 Pubmed: 39217154 ]
- Ccr6-bril/fab/nb in complex with sqa1 and oxm2 (120 MDa, Complex from Homo sapiens)
- Human ccr6 (54 kDa, Protein from Homo sapiens)
- Anti-bril fab nanobody (15 kDa, Protein from synthetic construct)
- Anti-bril fab light chain (25 kDa, Protein from Homo sapiens)
- N-{[(2r)-4-(bicyclo[1.1.1]pentan-1-yl)-5-oxomorpholin-2-yl]methyl}-1-[4-(trifluoromethyl)phenyl]cyclopropane-1-carboxamide (408 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- 4-[[3,4-bis(oxidanylidene)-2-[[(1~{r})-1-(4-propan-2-ylfuran-2-yl)propyl]amino]cyclobuten-1-yl]amino]-~{n},~{n}-dimethyl-3-oxidanyl-pyridine-2-carboxamide (426 Da, Ligand)
- Anti-bril fab heavy chain (28 kDa, Protein from Homo sapiens)
Cryo-EM structure of CCR6 bound by SQA1 and OXM1
Wasilko DJ, Gerstenberger BS, Farley KA, Li W, Alley J, Schnute ME, Unwalla RJ, Victorino J, Crouse KK, Ding R, Sahasrabudhe PV, Vincent F, Frisbie RK, Dermenci A, Flick A, Choi C, Chinigo G, Mousseau JJ, Trujillo JI, Nuhant P, Mondal P, Lombardo V, Lamb D, Hogan BJ, Minhas GS, Segala E, Oswald C, Windsor IW, Han S, Rappas M, Cooke RM, Calabrese MF, Berstein G, Thorarensen A, Wu H
Nat Commun (2024) 15 pp. 7574-7574 [ DOI: doi:10.1038/s41467-024-52045-7 Pubmed: 39217154 ]
- Ccr6, soluble cytochrome b562 (54 kDa, Protein from Homo sapiens)
- 1-(4-chlorophenyl)-n-{[(2r)-4-(2,3-dihydro-1h-inden-2-yl)-5-oxomorpholin-2-yl]methyl}cyclopropane-1-carboxamide (424 Da, Ligand)
- Anti-bril fab nanobody (15 kDa, Protein from synthetic construct)
- Anti-bril fab light chain (25 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Ccr6-bril/fab/nb in complex with sqa1 and oxm1 (120 MDa, Complex from Homo sapiens)
- 4-[[3,4-bis(oxidanylidene)-2-[[(1~{r})-1-(4-propan-2-ylfuran-2-yl)propyl]amino]cyclobuten-1-yl]amino]-~{n},~{n}-dimethyl-3-oxidanyl-pyridine-2-carboxamide (426 Da, Ligand)
- Anti-bril fab heavy chain (28 kDa, Protein from Homo sapiens)
the complex structure of the H4B6 Fab with the RBD of Omicron BA.5 S protein
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8ywx
Q-score: 0.387
Sun H, Xia L, Li J, Zhang Y, Zhang G, Huang P, Wang X, Cui Y, Fang T, Fan P, Zhou Q, Chi X, Yu C
Emerg Microbes Infect (2024) 13 pp. 2373307-2373307 [ DOI: doi:10.1080/22221751.2024.2373307 Pubmed: 38953857 ]
- The complex structure of the h4b6 fab with the rbd of omicron ba.5 s protein (Complex from Homo sapiens)
- Spike protein s2' (124 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- H4b6 fab's heavy chain (76 kDa, Protein from Homo sapiens)
- H4b6 fab's light chain (23 kDa, Protein from Homo sapiens)
SARS-CoV-2 Spike S2 bound to Fab 54043-5
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8vcr
Q-score: 0.535
Johnson NV, Wall SC, Kramer KJ, Holt CM, Periasamy S, Richardson SI, Manamela NP, Suryadevara N, Andreano E, Paciello I, Pierleoni G, Piccini G, Huang Y, Ge P, Allen JD, Uno N, Shiakolas AR, Pilewski KA, Nargi RS, Sutton RE, Abu-Shmais AA, Parks R, Haynes BF, Carnahan RH, Crowe Jr JE, Montomoli E, Rappuoli R, Bukreyev A, Ross TM, Sautto GA, McLellan JS, Georgiev IS
Structure (2024) 32 pp. 1893- [ Pubmed: 39326419 DOI: doi:10.1016/j.str.2024.08.022 ]
- S2 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike protein s2 (65 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Fab 54043-5 (Complex from Homo sapiens)
- 54043-5 fab light chain (23 kDa, Protein from Homo sapiens)
- Trimeric s2 bound to fab 54043-5 (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 54043-5 fab heavy chain (25 kDa, Protein from Homo sapiens)
SARS-CoV-2 spike omicron (BA.1) ectodomain trimer in complex with SC27 Fab, local refinement
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8vif
Q-score: 0.545
Voss WN, Mallory MA, Byrne PO, Marchioni JM, Knudson SA, Powers JM, Leist SR, Dadonaite B, Townsend DR, Kain J, Huang Y, Satterwhite E, Castillo IN, Mattocks M, Paresi C, Munt JE, Scobey T, Seeger A, Premkumar L, Bloom JD, Georgiou G, McLellan JS, Baric RS, Lavinder JJ, Ippolito GC
Cell Rep Med (2024) 5 pp. 101668-101668 [ DOI: doi:10.1016/j.xcrm.2024.101668 Pubmed: 39094579 ]
- Sc27 fab light chain (11 kDa, Protein from Homo sapiens)
- Sc27 fab heavy chain (14 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike omicron (ba.1) ectodomain trimer in complex with sc27 fab, global refinement (Complex)
- Sars-cov-2 spike omicron (ba.1) ectodomain (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (144 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sc27 fab (Complex from Homo sapiens)