Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7srs
Q-score: 0.523
Cao C, Barros-Alvarez X, Zhang S, Kim K, Damgen MA, Panova O, Suomivuori CM, Fay JF, Zhong X, Krumm BE, Gumpper RH, Seven AB, Robertson MJ, Krogan NJ, Huttenhain R, Nichols DE, Dror RO, Skiniotis G, Roth BL
Neuron (2022) 110 pp. 3154- [ Pubmed: 36087581 DOI: doi:10.1016/j.neuron.2022.08.006 ]
- Anti-5ht2br fab heavy chain (23 kDa, Protein from Mus musculus)
- Fab30 light chain (11 kDa, Protein from Mus musculus)
- Isoform 1b of beta-arrestin-1 (41 kDa, Protein from Homo sapiens)
- 5-ht2b receptor bound to lsd in complex with beta-arrestin1 (Complex)
- Anti-5ht2br fab light chain (22 kDa, Protein from Mus musculus)
- Fab30 heavy chain (13 kDa, Protein from Mus musculus)
- (8alpha)-n,n-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide (323 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 5-hydroxytryptamine receptor 2b (37 kDa, Protein from Homo sapiens)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7t9n
Q-score: 0.495
Faust B, Billesbolle CB, Suomivuori CM, Singh I, Zhang K, Hoppe N, Pinto AFM, Diedrich JK, Muftuoglu Y, Szkudlinski MW, Saghatelian A, Dror RO, Cheng Y, Manglik A
Nature (2022) 609 pp. 846-853 [ DOI: doi:10.1038/s41586-022-05159-1 Pubmed: 35940205 ]
- (2s)-3-hydroxypropane-1,2-diyl dihexadecanoate (568 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (30 kDa, Protein from Homo sapiens)
- M22 fab heavy chain (27 kDa, Protein from Homo sapiens)
- M22 agonist autoantibody bound to human thyrotropin receptor in complex with minigs399 (composite structure) (Complex)
- Thyrotropin receptor (79 kDa, Protein from Homo sapiens)
- M22 fab light chain (25 kDa, Protein from Homo sapiens)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7uap
Q-score: 0.384
Wang Z, Muecksch F, Cho A, Gaebler C, Hoffmann HH, Ramos V, Zong S, Cipolla M, Johnson B, Schmidt F, DaSilva J, Bednarski E, Ben Tanfous T, Raspe R, Yao K, Lee YE, Chen T, Turroja M, Milard KG, Dizon J, Kaczynska A, Gazumyan A, Oliveira TY, Rice CM, Caskey M, Bieniasz PD, Hatziioannou T, Barnes CO, Nussenzweig MC
Immunity (2022) 55 pp. 998-1012.e8 [ DOI: doi:10.1016/j.immuni.2022.04.003 Pubmed: 35447092 ]
- C1520 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- C1520 fab light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 s 6p + c1520 fab fragments (700 kDa, Complex from Homo sapiens)
Structure of the SARS-CoV-2 NTD in complex with C1520, local refinement
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7uaq
Q-score: 0.39
Wang Z, Muecksch F, Cho A, Gaebler C, Hoffmann HH, Ramos V, Zong S, Cipolla M, Johnson B, Schmidt F, DaSilva J, Bednarski E, Ben Tanfous T, Raspe R, Yao K, Lee YE, Chen T, Turroja M, Milard KG, Dizon J, Kaczynska A, Gazumyan A, Oliveira TY, Rice CM, Caskey M, Bieniasz PD, Hatziioannou T, Barnes CO, Nussenzweig MC
Immunity (2022) 55 pp. 998-1012.e8 [ DOI: doi:10.1016/j.immuni.2022.04.003 Pubmed: 35447092 ]
- C1520 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- C1520 fab light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 s 6p + c1520 fab fragments (700 kDa, Complex from Homo sapiens)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7uar
Q-score: 0.444
Wang Z, Muecksch F, Cho A, Gaebler C, Hoffmann HH, Ramos V, Zong S, Cipolla M, Johnson B, Schmidt F, DaSilva J, Bednarski E, Ben Tanfous T, Raspe R, Yao K, Lee YE, Chen T, Turroja M, Milard KG, Dizon J, Kaczynska A, Gazumyan A, Oliveira TY, Rice CM, Caskey M, Bieniasz PD, Hatziioannou T, Barnes CO, Nussenzweig MC
Immunity (2022) 55 pp. 998-1012.e8 [ DOI: doi:10.1016/j.immuni.2022.04.003 Pubmed: 35447092 ]
- Sars-cov-2 s 6p + c1717 fab fragments (700 kDa, Complex from Homo sapiens)
- C1717 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- C1717 fab light chain (22 kDa, Protein from Homo sapiens)
SARS-CoV-2 S-RBD + Fab 54042-4
Resolution: 2.69 Å
EM Method: Single-particle
Fitted PDBs: 7t01
Q-score: 0.463
Kramer KJ, Johnson NV, Shiakolas AR, Suryadevara N, Periasamy S, Raju N, Williams JK, Wrapp D, Zost SJ, Walker LM, Wall SC, Holt CM, Hsieh CL, Sutton RE, Paulo A, Nargi RS, Davidson E, Doranz BJ, Crowe Jr JE, Bukreyev A, Carnahan RH, McLellan JS, Georgiev IS
Cell Rep (2021) 37 pp. 109784-109784 [ DOI: doi:10.1016/j.celrep.2021.109784 Pubmed: 34592170 ]
- 54042-4 fab - heavy chain (13 kDa, Protein from Homo sapiens)
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 54042-4 fab - light chain (11 kDa, Protein from Homo sapiens)
- Complex of sars-cov-2 s-ecd with 54042-4 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
Resolution: 3.95 Å
EM Method: Single-particle
Fitted PDBs: 7r7n
Q-score: 0.411
Starr TN, Czudnochowski N, Liu Z, Zatta F, Park YJ, Addetia A, Pinto D, Beltramello M, Hernandez P, Greaney AJ, Marzi R, Glass WG, Zhang I, Dingens AS, Bowen JE, Tortorici MA, Walls AC, Wojcechowskyj JA, De Marco A, Rosen LE, Zhou J, Montiel-Ruiz M, Kaiser H, Dillen JR, Tucker H, Bassi J, Silacci-Fregni C, Housley MP, di Iulio J, Lombardo G, Agostini M, Sprugasci N, Culap K, Jaconi S, Meury M, Dellota Jr E, Abdelnabi R, Foo SC, Cameroni E, Stumpf S, Croll TI, Nix JC, Havenar-Daughton C, Piccoli L, Benigni F, Neyts J, Telenti A, Lempp FA, Pizzuto MS, Chodera JD, Hebner CM, Virgin HW, Whelan SPJ, Veesler D, Corti D, Bloom JD, Snell G
Nature (2021) 597 pp. 97-102 [ DOI: doi:10.1038/s41586-021-03807-6 Pubmed: 34261126 ]
- Sars-cov-2 spike in complex with the s2d106 neutralizing antibody fab fragment (Complex)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- S2d106 (Complex from Homo sapiens)
- Sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- S2d106 fab heavy chain (13 kDa, Protein from Homo sapiens)
- S2d106 fab light chain (11 kDa, Protein from Homo sapiens)
SARS-CoV 2 Spike Protein bound to LY-CoV555
Resolution: 3.27 Å
EM Method: Single-particle
Fitted PDBs: 7l3n
Q-score: 0.361
Jones BE, Brown-Augsburger PL, Corbett KS, Westendorf K, Davies J, Cujec TP, Wiethoff CM, Blackbourne JL, Heinz BA, Foster D, Higgs RE, Balasubramaniam D, Wang L, Bidshahri R, Kraft L, Hwang Y, Zentelis S, Jepson KR, Goya R, Smith MA, Collins DW, Hinshaw SJ, Tycho SA, Pellacani D, Xiang P, Muthuraman K, Sobhanifar S, Piper MH, Triana FJ, Hendle J, Pustilnik A, Adams AC, Berens SJ, Baric RS, Martinez DR, Cross RW, Geisbert TW, Borisevich V, Abiona O, Belli HM, de Vries M, Mohamed A, Dittmann M, Samanovic M, Mulligan MJ, Goldsmith JA, Hsieh CL, Johnson NV, Wrapp D, McLellan JS, Barnhart BC, Graham BS, Mascola JR, Hansen CL, Falconer E
bioRxiv (2020) [ DOI: doi:10.1101/2020.09.30.318972 Pubmed: 33024963 ]
- Sars-cov-2 spike protein bound to neutralizing antibody ly-cov555 (Complex)
- Ly-cov555 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Ly-cov555 fab light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Neutralizing antibody ly-cov555 (Complex from Homo sapiens)
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with bicuculline methbromide
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 6x3s
Q-score: 0.531
Kim JJ, Gharpure A, Teng J, Zhuang Y, Howard RJ, Zhu S, Noviello CM, Walsh Jr RM, Lindahl E, Hibbs RE
Nature (2020) 585 pp. 303-308 [ DOI: doi:10.1038/s41586-020-2654-5 Pubmed: 32879488 ]
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
- (5s)-6,6-dimethyl-5-[(6r)-8-oxo-6,8-dihydrofuro[3,4-e][1,3]benzodioxol-6-yl]-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-6-ium (382 Da, Ligand)
- Alpha-d-mannopyranose (180 Da, Ligand)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with bicuculline (Complex from Homo sapiens)
- Gamma-aminobutyric acid type a receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype (Complex from Homo sapiens)
- Igg2b/kappa antibody (Complex from Mus musculus)
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus propofol
Resolution: 2.55 Å
EM Method: Single-particle
Fitted PDBs: 6x3t
Q-score: 0.642
Kim JJ, Gharpure A, Teng J, Zhuang Y, Howard RJ, Zhu S, Noviello CM, Walsh Jr RM, Lindahl E, Hibbs RE
Nature (2020) 585 pp. 303-308 [ DOI: doi:10.1038/s41586-020-2654-5 Pubmed: 32879488 ]
- Gamma-aminobutyric acid receptor subunit beta-2 (41 kDa, Protein from Homo sapiens)
- 2,6-bis(1-methylethyl)phenol (178 Da, Ligand)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with gaba and propofol (Complex from Homo sapiens)
- Gamma-aminobutyric acid type a receptor subunit gamma-2 (47 kDa, Protein from Homo sapiens)
- Gamma-aminobutyric acid receptor subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Kappa fab light chain (23 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Human gaba-a receptor alpha1-beta2-gamma2 subtype (Complex from Homo sapiens)
- Igg2b/kappa antibody (Complex from Mus musculus)
- Igg2b fab heavy chain (49 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)