The BRIL-SLC19A1/Fab/Nb ternary complex
Resolution: 3.57 Å
EM Method: Single-particle
Fitted PDBs: 8hii
Q-score: 0.338
Dang Y, Zhou D, Du X, Zhao H, Lee CH, Yang J, Wang Y, Qin C, Guo Z, Zhang Z
Cell Discov (2022) 8 pp. 141-141 [ Pubmed: 36575193 DOI: doi:10.1038/s41421-022-00508-w ]
- Bril-slc19a1 chimera (75 kDa, Protein from Homo sapiens)
- Anti-fab nanobody (16 kDa, Protein from Lama glama)
- The bril-slc19a1/fab/nb ternary complex (Complex from Homo sapiens)
- Anti-bril fab heavy chain (27 kDa, Protein from Homo sapiens)
- Anti-bril fab light chain (25 kDa, Protein from Homo sapiens)
The 5-MTHF-bound BRIL-SLC19A1/Fab/Nb ternary complex
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 8hij
Q-score: 0.296
Dang Y, Zhou D, Du X, Zhao H, Lee CH, Yang J, Wang Y, Qin C, Guo Z, Zhang Z
Cell Discov (2022) 8 pp. 141-141 [ Pubmed: 36575193 DOI: doi:10.1038/s41421-022-00508-w ]
- Bril-slc19a1 chimera (75 kDa, Protein from Homo sapiens)
- Anti-fab nanobody (16 kDa, Protein from Lama glama)
- N-[4-({[(6s)-2-amino-4-hydroxy-5-methyl-5,6,7,8-tetrahydropteridin-6-yl]methyl}amino)benzoyl]-l-glutamic acid (459 Da, Ligand)
- Anti-bril fab light chain (25 kDa, Protein from Homo sapiens)
- Anti-bril fab heavy chain (27 kDa, Protein from Homo sapiens)
- The 5-mthf-bound bril-slc19a1/fab/nb ternary complex (Complex from Homo sapiens)
The TPP-bound BRIL-SLC19A1/Fab/Nb ternary complex
Resolution: 3.72 Å
EM Method: Single-particle
Fitted PDBs: 8hik
Q-score: 0.249
Dang Y, Zhou D, Du X, Zhao H, Lee CH, Yang J, Wang Y, Qin C, Guo Z, Zhang Z
Cell Discov (2022) 8 pp. 141-141 [ Pubmed: 36575193 DOI: doi:10.1038/s41421-022-00508-w ]
- The tpp-bound bril-slc19a1/fab/nb ternary complex (Complex from Homo sapiens)
- Bril-slc19a1 chimera (75 kDa, Protein from Homo sapiens)
- Anti-fab nanobody (16 kDa, Protein from Lama glama)
- Anti-bril fab light chain (25 kDa, Protein from Homo sapiens)
- Anti-bril fab heavy chain (27 kDa, Protein from Homo sapiens)
- Thiamine diphosphate (425 Da, Ligand)
Structure of the SARS-CoV-2 S 6P trimer in complex with the mouse antibody Fab fragment, M8a-3
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7uz4
Q-score: 0.368
Fan C, Cohen AA, Park M, Hung AF, Keeffe JR, Gnanapragasam PNP, Lee YE, Gao H, Kakutani LM, Wu Z, Kleanthous H, Malecek KE, Williams JC, Bjorkman PJ
Immunity (2022) 55 pp. 2419- [ Pubmed: 36370711 DOI: doi:10.1016/j.immuni.2022.10.019 ]
- Sars-cov-2 s 6p in complex with m8a-3 fab (25 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- M8a-3 fab heavy chain (25 kDa, Protein from Mus musculus)
- Severe acute respiratory syndrome coronavirus 2 spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- M8a-3 fab ch1 and cl domains (Complex from Mus musculus)
- M8a-3 fab light chain (23 kDa, Protein from Mus musculus)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- M8a-3 fab vh and vl domains (Complex from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of the SARS-CoV-2 S 6P trimer in complex with the mouse antibody Fab fragment, M8a-6
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7uz5
Q-score: 0.355
Fan C, Cohen AA, Park M, Hung AF, Keeffe JR, Gnanapragasam PNP, Lee YE, Gao H, Kakutani LM, Wu Z, Kleanthous H, Malecek KE, Williams JC, Bjorkman PJ
Immunity (2022) 55 pp. 2419- [ Pubmed: 36370711 DOI: doi:10.1016/j.immuni.2022.10.019 ]
- M8a-6 fab vh and vl domains (Complex from Mus musculus)
- M8a-6 fab ch1 and cl domains (Complex from Mus musculus)
- M8a-6 fab heavy chain (25 kDa, Protein from Mus musculus)
- Sars-cov-2 s 6p in complex with m8a-6 fab (25 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Severe acute respiratory syndrome coronavirus 2 spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- M8a-6 fab light chain (23 kDa, Protein from Mus musculus)
Structure of the SARS-CoV-2 S 6P trimer in complex with the mouse antibody Fab fragment, M8a-28
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7uz6
Q-score: 0.477
Fan C, Cohen AA, Park M, Hung AF, Keeffe JR, Gnanapragasam PNP, Lee YE, Gao H, Kakutani LM, Wu Z, Kleanthous H, Malecek KE, Williams JC, Bjorkman PJ
Immunity (2022) 55 pp. 2419- [ Pubmed: 36370711 DOI: doi:10.1016/j.immuni.2022.10.019 ]
- M8a-28 fab ch1 and cl domains (Complex from Mus musculus)
- Sars-cov-2 s 6p in complex with m8a-28 fab (25 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- M8a-28 fab heavy chain (25 kDa, Protein from Mus musculus)
- M8a-28 fab light chain (23 kDa, Protein from Mus musculus)
- Severe acute respiratory syndrome coronavirus 2 spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- M8a-28 fab vh and vl domains (Complex from Mus musculus)
Structure of the SARS-CoV-2 S 6P trimer in complex with the mouse antibody Fab fragment, M8a-31
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7uz7
Q-score: 0.36
Fan C, Cohen AA, Park M, Hung AF, Keeffe JR, Gnanapragasam PNP, Lee YE, Gao H, Kakutani LM, Wu Z, Kleanthous H, Malecek KE, Williams JC, Bjorkman PJ
Immunity (2022) 55 pp. 2419- [ Pubmed: 36370711 DOI: doi:10.1016/j.immuni.2022.10.019 ]
- M8a-31 fab light chain (24 kDa, Protein from Mus musculus)
- M8a-31 fab vh and vl domains (Complex from Mus musculus)
- M8a-31 fab heavy chain (24 kDa, Protein from Mus musculus)
- M8a-31 fab ch1 and cl domains (Complex from Mus musculus)
- Severe acute respiratory syndrome coronavirus 2 spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 s 6p in complex with m8a-31 fab (25 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7uz8
Q-score: 0.35
Fan C, Cohen AA, Park M, Hung AF, Keeffe JR, Gnanapragasam PNP, Lee YE, Gao H, Kakutani LM, Wu Z, Kleanthous H, Malecek KE, Williams JC, Bjorkman PJ
Immunity (2022) 55 pp. 2419- [ Pubmed: 36370711 DOI: doi:10.1016/j.immuni.2022.10.019 ]
- M8a-31 fab light chain (24 kDa, Protein from Mus musculus)
- M8a-31 fab vh and vl domains (Complex from Mus musculus)
- M8a-31 fab heavy chain (24 kDa, Protein from Mus musculus)
- M8a-31 fab ch1 and cl domains (Complex from Mus musculus)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 omicron ba.1 s 6p in complex with m8a-31 fab (25 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Severe acute respiratory syndrome coronavirus 2 omicron spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of the SARS-CoV-2 S 6P trimer in complex with the mouse antibody Fab fragment, M8a-34
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7uz9
Q-score: 0.289
Fan C, Cohen AA, Park M, Hung AF, Keeffe JR, Gnanapragasam PNP, Lee YE, Gao H, Kakutani LM, Wu Z, Kleanthous H, Malecek KE, Williams JC, Bjorkman PJ
Immunity (2022) 55 pp. 2419- [ Pubmed: 36370711 DOI: doi:10.1016/j.immuni.2022.10.019 ]
- M8a-34 fab ch1 and cl domains (Complex from Mus musculus)
- M8a-34 fab heavy chain (25 kDa, Protein from Mus musculus)
- M8a-34 fab light chain (23 kDa, Protein from Mus musculus)
- Severe acute respiratory syndrome coronavirus 2 spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- M8a-34 fab vh and vl domains (Complex from Mus musculus)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 s 6p in complex with m8a-34 fab (25 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of the SARS-CoV-2 S 6P trimer in complex with the mouse antibody Fab fragment, HSW-1
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7uza
Q-score: 0.377
Fan C, Cohen AA, Park M, Hung AF, Keeffe JR, Gnanapragasam PNP, Lee YE, Gao H, Kakutani LM, Wu Z, Kleanthous H, Malecek KE, Williams JC, Bjorkman PJ
Immunity (2022) 55 pp. 2419- [ Pubmed: 36370711 DOI: doi:10.1016/j.immuni.2022.10.019 ]
- Hsw-1 fab ch1 and cl domains (Complex from Mus musculus)
- Sars-cov-2 s 6p in complex with hsw-1 fab (25 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Hsw-1 fab light chain (23 kDa, Protein from Mus musculus)
- Hsw-1 fab heavy chain (25 kDa, Protein from Mus musculus)
- Severe acute respiratory syndrome coronavirus 2 spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Hsw-1 fab vh and vl domains (Complex from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)