Modifying portion of human FASN with NADPH and the ACP at the ER domain
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8vf7
Q-score: 0.487
Schultz K, Costa-Pinheiro P, Gardner L, Pinheiro LV, Ramirez-Solis J, Gardner SM, Wellen KE, Marmorstein R
To Be Published
- Human fatty acid synthase (554 kDa, Complex from Homo sapiens)
- Fatty acid synthase (278 kDa, Protein from Homo sapiens)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
- Fatty acid synthase (279 kDa, Protein from Homo sapiens)
Modifying portion of human FASN with NADPH and the ACP at the DH domain
Resolution: 3.11 Å
EM Method: Single-particle
Fitted PDBs: 8vg4
Q-score: 0.492
Schultz K, Costa-Pinheiro P, Gardner L, Pinheiro LV, Ramirez-Solis J, Gardner SM, Wellen KE, Marmorstein R
To Be Published
- Human fatty acid synthase (554 kDa, Complex from Homo sapiens)
- Fatty acid synthase (278 kDa, Protein from Homo sapiens)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
- Fatty acid synthase (279 kDa, Protein from Homo sapiens)
Composite structure of human FASN with NADPH in State 1
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8vle
Q-score: 0.469
Schultz K, Costa-Pinheiro P, Gardner L, Pinheiro LV, Ramirez-Solis J, Gardner SM, Wellen KE, Marmorstein R
Nature (2025) [ DOI: doi:10.1038/s41586-025-08587-x ]
- Human fatty acid synthase (554 kDa, Complex from Homo sapiens)
- Fatty acid synthase (278 kDa, Protein from Homo sapiens)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Composite structure of human FASN with NADPH in State 2
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8vlo
Q-score: 0.466
Schultz K, Costa-Pinheiro P, Gardner L, Pinheiro LV, Ramirez-Solis J, Gardner SM, Wellen KE, Marmorstein R
Nature (2025) [ DOI: doi:10.1038/s41586-025-08587-x ]
- Human fatty acid synthase (554 kDa, Complex from Homo sapiens)
- Fatty acid synthase (278 kDa, Protein from Homo sapiens)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Composite structure of human FASN with NADPH in State 3
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8vlp
Q-score: 0.474
Schultz K, Costa-Pinheiro P, Gardner L, Pinheiro LV, Ramirez-Solis J, Gardner SM, Wellen KE, Marmorstein R
Nature (2025) [ DOI: doi:10.1038/s41586-025-08587-x ]
- Human fatty acid synthase (554 kDa, Complex from Homo sapiens)
- Fatty acid synthase (278 kDa, Protein from Homo sapiens)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Composite structure of human FASN with NADPH in State 4
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8vm0
Q-score: 0.453
Schultz K, Costa-Pinheiro P, Gardner L, Pinheiro LV, Ramirez-Solis J, Gardner SM, Wellen KE, Marmorstein R
Nature (2025) [ DOI: doi:10.1038/s41586-025-08587-x ]
- Human fatty acid synthase (554 kDa, Complex from Homo sapiens)
- Fatty acid synthase (278 kDa, Protein from Homo sapiens)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Composite structure of human FASN with NADPH in State 5
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8vm5
Q-score: 0.452
Schultz K, Costa-Pinheiro P, Gardner L, Pinheiro LV, Ramirez-Solis J, Gardner SM, Wellen KE, Marmorstein R
Nature (2025) [ DOI: doi:10.1038/s41586-025-08587-x ]
- Human fatty acid synthase (554 kDa, Complex from Homo sapiens)
- Fatty acid synthase (278 kDa, Protein from Homo sapiens)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Composite structure of human FASN with NADPH in State 8
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8vm6
Q-score: 0.429
Schultz K, Costa-Pinheiro P, Gardner L, Pinheiro LV, Ramirez-Solis J, Gardner SM, Wellen KE, Marmorstein R
Nature (2025) [ DOI: doi:10.1038/s41586-025-08587-x ]
- Human fatty acid synthase (554 kDa, Complex from Homo sapiens)
- Fatty acid synthase (278 kDa, Protein from Homo sapiens)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Composite structure of human FASN with NADPH in State 7
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8vm7
Q-score: 0.463
Schultz K, Costa-Pinheiro P, Gardner L, Pinheiro LV, Ramirez-Solis J, Gardner SM, Wellen KE, Marmorstein R
Nature (2025) [ DOI: doi:10.1038/s41586-025-08587-x ]
- Human fatty acid synthase (554 kDa, Complex from Homo sapiens)
- Fatty acid synthase (278 kDa, Protein from Homo sapiens)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Composite structure of human FASN with NADPH in State 6
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8vmc
Q-score: 0.464
Schultz K, Costa-Pinheiro P, Gardner L, Pinheiro LV, Ramirez-Solis J, Gardner SM, Wellen KE, Marmorstein R
Nature (2025) [ DOI: doi:10.1038/s41586-025-08587-x ]
- Human fatty acid synthase (554 kDa, Complex from Homo sapiens)
- Fatty acid synthase (278 kDa, Protein from Homo sapiens)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)