MBP-tagged fusion fatty acid synthase from S. cerevisiae
Samani EK, Chen AC, Lou JW, Dai DL, Keszei AFA, Tan G, Boone C, Grininger M, Mazhab-Jafari MT
Commun Biol (2024) 7 pp. 92-92 [ DOI: doi:10.1038/s42003-024-05777-7 Pubmed: 38216676 ]
MBP tagged and Mixed chain fatty acid synthase, FAS2_deltaACP
Samani EK, Chen AC, Lou JW, Dai DL, Keszei AFA, Tan G, Boone C, Grininger M, Mazhab-Jafari MT
Commun Biol (2024) 7 pp. 92-92 [ DOI: doi:10.1038/s42003-024-05777-7 Pubmed: 38216676 ]
MBP tagged mixed chain FAS, fusFAS_deltaACP
Samani EK, Chen AC, Lou JW, Dai DL, Keszei AFA, Tan G, Boone C, Grininger M, Mazhab-Jafari MT
Commun Biol (2024) 7 pp. 92-92 [ DOI: doi:10.1038/s42003-024-05777-7 Pubmed: 38216676 ]
Atomic model of the core modifying region of human fatty acid synthase
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8eyi
Q-score: 0.521
Hasan SMN, Lou JW, Keszei AFA, Dai DL, Mazhab-Jafari MT
Nat Commun (2023) 14 pp. 3460-3460 [ DOI: doi:10.1038/s41467-023-39266-y Pubmed: 37308485 ]
- Fatty acid synthase (182 kDa, Protein from Homo sapiens)
- Fatty acid synthase (340 kDa, Complex from Homo sapiens)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Atomic model of the core modifying region of human fatty acid synthase in complex with TVB-2640
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8eyk
Q-score: 0.555
Hasan SMN, Lou JW, Keszei AFA, Dai DL, Mazhab-Jafari MT
Nat Commun (2023) 14 pp. 3460-3460 [ DOI: doi:10.1038/s41467-023-39266-y Pubmed: 37308485 ]
- Denifanstat (439 Da, Ligand)
- Fatty acid synthase (182 kDa, Protein from Homo sapiens)
- Fatty acid synthase (340 kDa, Complex from Homo sapiens)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Resolution: 2.45 Å
EM Method: Single-particle
Fitted PDBs: 8gkc
Q-score: 0.612
Hasan SMN, Lou JW, Keszei AFA, Dai DL, Mazhab-Jafari MT
Nat Commun (2023) 14 pp. 3460-3460 [ DOI: doi:10.1038/s41467-023-39266-y Pubmed: 37308485 ]
- Denifanstat (439 Da, Ligand)
- Fatty acid synthase (182 kDa, Protein from Homo sapiens)
- Fatty acid synthase (340 kDa, Complex from Homo sapiens)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Resolution: 5.8 Å
EM Method: Single-particle
Fitted PDBs: 6wc7
Q-score: 0.283
Commun Biol (2020) 3 pp. 274-274 [ Pubmed: 32471977 DOI: doi:10.1038/s42003-020-0997-y ]
- Fatty acid synthase (2 MDa, Complex from Saccharomyces cerevisiae)
- Fatty acid synthase subunit beta (229 kDa, Protein from Saccharomyces cerevisiae)
- Fatty acid synthase subunit alpha (207 kDa, Protein from Saccharomyces cerevisiae)
Electron cryomicroscopy Structure of S. cerevisiae FAS in the Apo state
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 6u5t
Q-score: 0.442
Lou JW, Iyer KR, Hasan SMN, Cowen LE, Mazhab-Jafari MT
Sci Rep (2019) 9 pp. 12987-12987 [ Pubmed: 31506493 DOI: doi:10.1038/s41598-019-49261-3 ]
- Fatty acid synthase subunit beta (231 kDa, Protein from Baker's yeast)
- Flavin mononucleotide (456 Da, Ligand)
- Fatty acid synthase subunit alpha (207 kDa, Protein from Baker's yeast)
- Fatty acid synthase (2 MDa, Complex from Saccharomyces cerevisiae)
- 4'-phosphopantetheine (358 Da, Ligand)
Electron cryomicroscopy Structure of S. cerevisiae FAS in the KS-stalled state
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 6u5u
Q-score: 0.449
Lou JW, Iyer KR, Hasan SMN, Cowen LE, Mazhab-Jafari MT
Sci Rep (2019) 9 pp. 12987-12987 [ Pubmed: 31506493 DOI: doi:10.1038/s41598-019-49261-3 ]
- Fatty acid synthase subunit beta (231 kDa, Protein from Baker's yeast)
- Flavin mononucleotide (456 Da, Ligand)
- Nadp nicotinamide-adenine-dinucleotide phosphate (743 Da, Ligand)
- Fatty acid synthase subunit alpha (207 kDa, Protein from Baker's yeast)
- Fatty acid synthase (2 MDa, Complex from Saccharomyces cerevisiae)
- 4'-phosphopantetheine (358 Da, Ligand)
Electron cryomicroscopy Structure of C. albicans FAS in the Apo state
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 6u5v
Q-score: 0.453
Lou JW, Iyer KR, Hasan SMN, Cowen LE, Mazhab-Jafari MT
Sci Rep (2019) 9 pp. 12987-12987 [ Pubmed: 31506493 DOI: doi:10.1038/s41598-019-49261-3 ]
- Flavin mononucleotide (456 Da, Ligand)
- Fatty acid synthase subunit alpha (207 kDa, Protein from Yeast)
- Fatty acid synthase subunit beta (228 kDa, Protein from Yeast)
- Fatty acid synthase (2 MDa, Complex from Candida albicans)
- 4'-phosphopantetheine (358 Da, Ligand)