Saccharomyces cerevisiae FAS type I
Henderikx RJM, Mann D, Domanska A, Dong J, Shahzad S, Lak B, Filopoulou A, Ludig D, Grininger M, Momoh J, Laanto E, Oksanen HM, Bisikalo K, Williams PA, Butcher SJ, Peters PJ, Beulen BWAMM
Acta Crystallogr D Struct Biol (2024) 80 pp. 232-246 [ DOI: doi:10.1107/S2059798324001852 Pubmed: 38488730 ]
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8prv
Q-score: 0.581
Singh K, Bunzel G, Graf B, Yip KM, Neumann-Schaal M, Stark H, Chari A
Cell (2023) 186 pp. 5054-5067.e16 [ Pubmed: 37949058 DOI: doi:10.1016/j.cell.2023.10.009 ]
- Yeast fatty acid synthase (Complex from Saccharomyces cerevisiae)
- Flavin mononucleotide (456 Da, Ligand)
- ~{s}-[2-[3-[[(2~{r})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] 3-oxidanylidenebutanethioate (442 Da, Ligand)
- Nadp nicotinamide-adenine-dinucleotide phosphate (743 Da, Ligand)
- Fatty acid synthase subunit alpha (207 kDa, Protein from Saccharomyces cerevisiae)
- Coenzyme a (767 Da, Ligand)
- Fatty acid synthase subunit beta (229 kDa, Protein from Saccharomyces cerevisiae)
Cryo-EM structure of the yeast fatty acid synthase at 1.9 angstrom resolution
Resolution: 1.9 Å
EM Method: Single-particle
Fitted PDBs: 8prw
Q-score: 0.712
Singh K, Bunzel G, Graf B, Yip KM, Neumann-Schaal M, Stark H, Chari A
Cell (2023) 186 pp. 5054-5067.e16 [ Pubmed: 37949058 DOI: doi:10.1016/j.cell.2023.10.009 ]
- Water (18 Da, Ligand)
- Yeast fatty acid synthase (Complex from Saccharomyces cerevisiae)
- 1-deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydro-2h-benzo[g]pteridin-1-id-10(5h)-yl)-5-o-phosphonato-d-ribitol (458 Da, Ligand)
- Nadp nicotinamide-adenine-dinucleotide phosphate (743 Da, Ligand)
- Fatty acid synthase subunit alpha (207 kDa, Protein from Saccharomyces cerevisiae)
- Coenzyme a (767 Da, Ligand)
- Fatty acid synthase subunit beta (229 kDa, Protein from Saccharomyces cerevisiae)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8ps1
Q-score: 0.588
Singh K, Bunzel G, Graf B, Yip KM, Neumann-Schaal M, Stark H, Chari A
Cell (2023) 186 pp. 5054-5067.e16 [ Pubmed: 37949058 DOI: doi:10.1016/j.cell.2023.10.009 ]
- Yeast fatty acid synthase (Complex from Saccharomyces cerevisiae)
- Flavin mononucleotide (456 Da, Ligand)
- Nadp nicotinamide-adenine-dinucleotide phosphate (743 Da, Ligand)
- Fatty acid synthase subunit alpha (207 kDa, Protein from Saccharomyces cerevisiae)
- Coenzyme a (767 Da, Ligand)
- Fatty acid synthase subunit beta (229 kDa, Protein from Saccharomyces cerevisiae)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8ps2
Q-score: 0.575
Singh K, Bunzel G, Graf B, Yip KM, Neumann-Schaal M, Stark H, Chari A
Cell (2023) 186 pp. 5054-5067.e16 [ Pubmed: 37949058 DOI: doi:10.1016/j.cell.2023.10.009 ]
- Yeast fatty acid synthase (Complex from Saccharomyces cerevisiae)
- Fatty acid synthase subunit beta (228 kDa, Protein from Saccharomyces cerevisiae)
- Malonyl-coenzyme a (853 Da, Ligand)
- Flavin mononucleotide (456 Da, Ligand)
- ~{s}-[2-[3-[[(2~{r})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (~{e})-but-2-enethioate (426 Da, Ligand)
- Fatty acid synthase subunit alpha (207 kDa, Protein from Saccharomyces cerevisiae)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8ps8
Q-score: 0.38
Singh K, Bunzel G, Graf B, Yip KM, Neumann-Schaal M, Stark H, Chari A
Cell (2023) 186 pp. 5054-5067.e16 [ Pubmed: 37949058 DOI: doi:10.1016/j.cell.2023.10.009 ]
- Fatty acid synthase subunit alpha (207 kDa, Protein from Saccharomyces cerevisiae)
- Yeast fatty acid synthase (Complex from Saccharomyces cerevisiae)
- Fatty acid synthase subunit beta (228 kDa, Protein from Saccharomyces cerevisiae)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8ps9
Q-score: 0.574
Singh K, Bunzel G, Graf B, Yip KM, Neumann-Schaal M, Stark H, Chari A
Cell (2023) 186 pp. 5054-5067.e16 [ Pubmed: 37949058 DOI: doi:10.1016/j.cell.2023.10.009 ]
- Yeast fatty acid synthase (Complex from Saccharomyces cerevisiae)
- Malonyl-coenzyme a (853 Da, Ligand)
- Fatty acid synthase subunit beta (228 kDa, Protein from Saccharomyces cerevisiae)
- Flavin mononucleotide (456 Da, Ligand)
- Fatty acid synthase subunit alpha (207 kDa, Protein from Saccharomyces cerevisiae)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8psa
Q-score: 0.423
Singh K, Bunzel G, Graf B, Yip KM, Neumann-Schaal M, Stark H, Chari A
Cell (2023) 186 pp. 5054-5067.e16 [ Pubmed: 37949058 DOI: doi:10.1016/j.cell.2023.10.009 ]
- Fatty acid synthase subunit alpha (207 kDa, Protein from Saccharomyces cerevisiae)
- Flavin mononucleotide (456 Da, Ligand)
- Yeast fatty acid synthase (Complex from Saccharomyces cerevisiae)
- Fatty acid synthase subunit beta (228 kDa, Protein from Saccharomyces cerevisiae)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8psf
Q-score: 0.541
Singh K, Bunzel G, Graf B, Yip KM, Neumann-Schaal M, Stark H, Chari A
Cell (2023) 186 pp. 5054-5067.e16 [ Pubmed: 37949058 DOI: doi:10.1016/j.cell.2023.10.009 ]
- Yeast fatty acid synthase (Complex from Saccharomyces cerevisiae)
- Fatty acid synthase subunit beta (228 kDa, Protein from Saccharomyces cerevisiae)
- Flavin mononucleotide (456 Da, Ligand)
- 4'-phosphopantetheine (358 Da, Ligand)
- Fatty acid synthase subunit alpha (207 kDa, Protein from Saccharomyces cerevisiae)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8psg
Q-score: 0.407
Singh K, Bunzel G, Graf B, Yip KM, Neumann-Schaal M, Stark H, Chari A
Cell (2023) 186 pp. 5054-5067.e16 [ Pubmed: 37949058 DOI: doi:10.1016/j.cell.2023.10.009 ]
- Fatty acid synthase subunit alpha (207 kDa, Protein from Saccharomyces cerevisiae)
- Flavin mononucleotide (456 Da, Ligand)
- Yeast fatty acid synthase (Complex from Saccharomyces cerevisiae)
- Fatty acid synthase subunit beta (228 kDa, Protein from Saccharomyces cerevisiae)