Cryo-EM structure of the 3-OH-C12-bound GPR84 receptor-Gi complex
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 8j18
Q-score: 0.499
Liu H, Zhang Q, He X, Jiang M, Wang S, Yan X, Cheng X, Liu Y, Nan FJ, Xu HE, Xie X, Yin W
Nat Commun (2023) 14 pp. 3271-3271 [ Pubmed: 37277332 DOI: doi:10.1038/s41467-023-38985-6 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- G-protein coupled receptor 84 (45 kDa, Protein from Homo sapiens)
- (3r)-3-hydroxydodecanoic acid (216 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- 3-oh-c12-bound gpr84 receptor-gi complex (Complex from Homo sapiens)
- Antibody fragment scfv16 (28 kDa, Protein from synthetic construct)
Cryo-EM structure of the LY237-bound GPR84 receptor-Gi complex
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 8j19
Q-score: 0.49
Liu H, Zhang Q, He X, Jiang M, Wang S, Yan X, Cheng X, Liu Y, Nan FJ, Xu HE, Xie X, Yin W
Nat Commun (2023) 14 pp. 3271-3271 [ Pubmed: 37277332 DOI: doi:10.1038/s41467-023-38985-6 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- G-protein coupled receptor 84 (45 kDa, Protein from Homo sapiens)
- 6-nonylpyridine-2,4-diol (237 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Ly237-bound gpr84 receptor-gi complex (Complex from Homo sapiens)
- Antibody fragment scfv16 (28 kDa, Protein from synthetic construct)
Cryo-EM structure of the GPR84 receptor-Gi complex with no ligand modeled
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 8j1a
Q-score: 0.484
Liu H, Zhang Q, He X, Jiang M, Wang S, Yan X, Cheng X, Liu Y, Nan FJ, Xu HE, Xie X, Yin W
Nat Commun (2023) 14 pp. 3271-3271 [ Pubmed: 37277332 DOI: doi:10.1038/s41467-023-38985-6 ]
- Gpr84 receptor-gi complex with no ligand modeled (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- G-protein coupled receptor 84 (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (28 kDa, Protein from synthetic construct)
Lodoxamide-bound GPR35 in complex with G13
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8h8j
Q-score: 0.416
Duan J, Liu Q, Yuan Q, Ji Y, Zhu S, Tan Y, He X, Xu Y, Shi J, Cheng X, Jiang H, Eric Xu H, Jiang Y
Cell Discov (2022) 8 pp. 135-135 [ DOI: doi:10.1038/s41421-022-00499-8 Pubmed: 36543774 ]
- Lodoxamide-gpr35-g13 complex (Complex from Homo sapiens)
- G-protein coupled receptor 35 (33 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- 2,2'-[(2-chloro-5-cyano-1,3-phenylene)bis(azanediyl)]bis(oxoacetic acid) (311 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein subunit alpha-13 (42 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)