CryoEM structure of Gi-coupled MRGPRX1 with peptide agonist CNF-Tx2
Resolution: 2.84 Å
EM Method: Single-particle
Fitted PDBs: 8jgb
Q-score: 0.551
Guo L, Zhang Y, Fang G, Tie L, Zhuang Y, Xue C, Liu Q, Zhang M, Zhu K, You C, Xu P, Yuan Q, Zhang C, Liu L, Rong N, Peng S, Liu Y, Wang C, Luo X, Lv Z, Kang D, Yu X, Zhang C, Jiang Y, Dong X, Zhou J, Liu Z, Yang F, Eric Xu H, Sun JP
Nat Commun (2023) 14 pp. 5004-5004 [ Pubmed: 37591889 DOI: doi:10.1038/s41467-023-40705-z ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from Homo sapiens)
- Mas-related g-protein coupled receptor member x1 (35 kDa, Protein from Homo sapiens)
- Cryo-em structure of the bam8-22-bound mrgprx1-gq complex (Complex from Homo sapiens)
- Conorfamide-tx2 (2 kDa, Protein from Conus textile)
CryoEM structure of Gq-coupled MRGPRX1 with peptide agonist BAM8-22
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8jgf
Q-score: 0.486
Guo L, Zhang Y, Fang G, Tie L, Zhuang Y, Xue C, Liu Q, Zhang M, Zhu K, You C, Xu P, Yuan Q, Zhang C, Liu L, Rong N, Peng S, Liu Y, Wang C, Luo X, Lv Z, Kang D, Yu X, Zhang C, Jiang Y, Dong X, Zhou J, Liu Z, Yang F, Eric Xu H, Sun JP
Nat Commun (2023) 14 pp. 5004-5004 [ Pubmed: 37591889 DOI: doi:10.1038/s41467-023-40705-z ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Mas-related g-protein coupled receptor member x1 (35 kDa, Protein from Homo sapiens)
- Bam8-22 (1 kDa, Protein from Homo sapiens)
- Cryo-em structure of the bam8-22-bound mrgprx1-gq complex (Complex from Homo sapiens)
- Single-chain fragment variable 16 (30 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein gq (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
CryoEM structure of Gi-coupled MRGPRX1 with peptide agonist BAM8-22
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8jgg
Q-score: 0.54
Guo L, Zhang Y, Fang G, Tie L, Zhuang Y, Xue C, Liu Q, Zhang M, Zhu K, You C, Xu P, Yuan Q, Zhang C, Liu L, Rong N, Peng S, Liu Y, Wang C, Luo X, Lv Z, Kang D, Yu X, Zhang C, Jiang Y, Dong X, Zhou J, Liu Z, Yang F, Eric Xu H, Sun JP
Nat Commun (2023) 14 pp. 5004-5004 [ Pubmed: 37591889 DOI: doi:10.1038/s41467-023-40705-z ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Single-chain fragment variable 16 (30 kDa, Protein from Homo sapiens)
- Mas-related g-protein coupled receptor member x1 (36 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Cryoem structure of gi-coupled mrgprx1 with peptide agonist bam8-22 (Complex from Homo sapiens)
- Bam8-22 (1 kDa, Protein from Homo sapiens)
Cryo-EM structure of the 3-OH-C12-bound GPR84 receptor-Gi complex
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 8j18
Q-score: 0.499
Liu H, Zhang Q, He X, Jiang M, Wang S, Yan X, Cheng X, Liu Y, Nan FJ, Xu HE, Xie X, Yin W
Nat Commun (2023) 14 pp. 3271-3271 [ Pubmed: 37277332 DOI: doi:10.1038/s41467-023-38985-6 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- G-protein coupled receptor 84 (45 kDa, Protein from Homo sapiens)
- (3r)-3-hydroxydodecanoic acid (216 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- 3-oh-c12-bound gpr84 receptor-gi complex (Complex from Homo sapiens)
- Antibody fragment scfv16 (28 kDa, Protein from synthetic construct)
Cryo-EM structure of the LY237-bound GPR84 receptor-Gi complex
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 8j19
Q-score: 0.49
Liu H, Zhang Q, He X, Jiang M, Wang S, Yan X, Cheng X, Liu Y, Nan FJ, Xu HE, Xie X, Yin W
Nat Commun (2023) 14 pp. 3271-3271 [ Pubmed: 37277332 DOI: doi:10.1038/s41467-023-38985-6 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- G-protein coupled receptor 84 (45 kDa, Protein from Homo sapiens)
- 6-nonylpyridine-2,4-diol (237 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Ly237-bound gpr84 receptor-gi complex (Complex from Homo sapiens)
- Antibody fragment scfv16 (28 kDa, Protein from synthetic construct)
Cryo-EM structure of the GPR84 receptor-Gi complex with no ligand modeled
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 8j1a
Q-score: 0.484
Liu H, Zhang Q, He X, Jiang M, Wang S, Yan X, Cheng X, Liu Y, Nan FJ, Xu HE, Xie X, Yin W
Nat Commun (2023) 14 pp. 3271-3271 [ Pubmed: 37277332 DOI: doi:10.1038/s41467-023-38985-6 ]
- Gpr84 receptor-gi complex with no ligand modeled (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- G-protein coupled receptor 84 (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (28 kDa, Protein from synthetic construct)
Lodoxamide-bound GPR35 in complex with G13
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8h8j
Q-score: 0.416
Duan J, Liu Q, Yuan Q, Ji Y, Zhu S, Tan Y, He X, Xu Y, Shi J, Cheng X, Jiang H, Eric Xu H, Jiang Y
Cell Discov (2022) 8 pp. 135-135 [ DOI: doi:10.1038/s41421-022-00499-8 Pubmed: 36543774 ]
- Lodoxamide-gpr35-g13 complex (Complex from Homo sapiens)
- G-protein coupled receptor 35 (33 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- 2,2'-[(2-chloro-5-cyano-1,3-phenylene)bis(azanediyl)]bis(oxoacetic acid) (311 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein subunit alpha-13 (42 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of the beclomethasone-bound adhesion receptor GPR97-Go complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7d76
Q-score: 0.526
Ping YQ, Mao C, Xiao P, Zhao RJ, Jiang Y, Yang Z, An WT, Shen DD, Yang F, Zhang H, Qu C, Shen Q, Tian C, Li ZJ, Li S, Wang GY, Tao X, Wen X, Zhong YN, Yang J, Yi F, Yu X, Xu HE, Zhang Y, Sun JP
Nature (2021) 589 pp. 620-626 [ DOI: doi:10.1038/s41586-020-03083-w Pubmed: 33408414 ]
- (8~{s},9~{r},10~{s},11~{s},13~{s},14~{s},16~{s},17~{r})-9-chloranyl-10,13,16-trimethyl-11,17-bis(oxidanyl)-17-(2-oxidanylethanoyl)-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one (408 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Adhesion g protein-coupled receptor g3; gpr97 (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Guanine nucleotide-binding protein g(o) subunit alpha (25 kDa, Protein from Homo sapiens)
- Beclomethasone-bound adhesion receptor gpr97-go complex (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Go (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Adhesion g protein-coupled receptor g3; gpr97 (62 kDa, Protein from Homo sapiens)
Cryo-EM structure of the cortisol-bound adhesion receptor GPR97-Go complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7d77
Q-score: 0.56
Ping YQ, Mao C, Xiao P, Zhao RJ, Jiang Y, Yang Z, An WT, Shen DD, Yang F, Zhang H, Qu C, Shen Q, Tian C, Li ZJ, Li S, Wang GY, Tao X, Wen X, Zhong YN, Yang J, Yi F, Yu X, Xu HE, Zhang Y, Sun JP
Nature (2021) 589 pp. 620-626 [ DOI: doi:10.1038/s41586-020-03083-w Pubmed: 33408414 ]
- (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione (362 Da, Ligand)
- Water (18 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Adhesion g protein-coupled receptor g3; gpr97 (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(o) subunit alpha (25 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Go (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Cortisol-bound adhesion receptor gpr97-go complex (Complex)
- Adhesion g protein-coupled receptor g3; gpr97 (62 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from synthetic construct)