CryoEM structure of Gq-coupled MRGPRD with a new agonist EP-2825
Resolution: 2.92 Å
EM Method: Single-particle
Fitted PDBs: 9dqh
Q-score: 0.123
Wang C, Liu Y, Lanier M, Yeager A, Singh I, Gumpper RH, Krumm BE, DeLeon C, Zhang S, Boehm M, Pittner R, Baron A, Dvorak L, Bacon C, Shoichet BK, Martinborough E, Fay JF, Cao C, Roth BL
Cell Rep (2024) 43 pp. 114942-114942 [ DOI: doi:10.1016/j.celrep.2024.114942 Pubmed: 39580805 ]
- Scfv16 (27 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Ep-2825-bound mrgprd-gq complex (137 kDa, Complex)
- Gs-mini-gq chimera (28 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Mas-related g-protein coupled receptor member d (36 kDa, Protein from Homo sapiens)
- 2-({1-[2-(4-chlorophenyl)-2-methylpropanoyl]piperidin-4-yl}amino)-5,6,7,8-tetrahydroquinazolin-4(3h)-one (428 Da, Ligand)
CryoEM structure of Gq-coupled MRGPRD with a new agonist EP-3945
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 9dqj
Q-score: 0.095
Wang C, Liu Y, Lanier M, Yeager A, Singh I, Gumpper RH, Krumm BE, DeLeon C, Zhang S, Boehm M, Pittner R, Baron A, Dvorak L, Bacon C, Shoichet BK, Martinborough E, Fay JF, Cao C, Roth BL
Cell Rep (2024) 43 pp. 114942-114942 [ DOI: doi:10.1016/j.celrep.2024.114942 Pubmed: 39580805 ]
- G(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Scfv16 (27 kDa, Protein from Mus musculus)
- 2-({1-[1-(4-methoxyphenyl)cyclopropane-1-carbonyl]piperidin-4-yl}amino)quinazolin-4(3h)-one (418 Da, Ligand)
- Ep-3945-bound mrgprd-gq complex (137 kDa, Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- G(i) subunit alpha-2/g(s) subunit alpha isoforms xlas (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-2,guanine nucleotide-binding protein g(s) subunit alpha isoforms xlas (28 kDa, Protein from Homo sapiens)
- Mas-related g-protein coupled receptor member d (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Mas-related g-protein coupled receptor member d (36 kDa, Protein from Homo sapiens)
- G(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
Cryo-EM structure of kisspeptin receptor bound to KP-10
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8zjd
Q-score: 0.495
Shen S, Wang D, Liu H, He X, Cao Y, Chen J, Li S, Cheng X, Xu HE, Duan J
Cell Rep (2024) 43 pp. 114389-114389 [ DOI: doi:10.1016/j.celrep.2024.114389 Pubmed: 38935498 ]
- Kiss-1 receptor,kiss-1 receptor,kiss-1 receptor,kiss-1 receptor,kiss-1 receptor, g-protein coupled receptor 54, gpr54, kiss1r (55 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus sp.)
- Cryo-em structure of kisspeptin receptor in complex with g proteins (Complex from Homo Sapiens)
- Kisspeptin-10 (1 kDa, Protein from synthetic construct)