GLP-1 receptor bound with Pfizer small molecule agonist
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7s15
Q-score: 0.405
Griffith DA, Edmonds DJ, Fortin JP, Kalgutkar AS, Kuzmiski JB, Loria PM, Saxena AR, Bagley SW, Buckeridge C, Curto JM, Derksen DR, Dias JM, Griffor MC, Han S, Jackson VM, Landis MS, Lettiere D, Limberakis C, Liu Y, Mathiowetz AM, Patel JC, Piotrowski DW, Price DA, Ruggeri RB, Tess DA
J Med Chem (2022) 65 pp. 8208-8226 [ Pubmed: 35647711 DOI: doi:10.1021/acs.jmedchem.1c01856 ]
Cryo-EM structure of the compound 2-bound human GLP-1 receptor-Gs complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7dur
Q-score: 0.273
Cong Z, Chen LN, Ma H, Zhou Q, Zou X, Ye C, Dai A, Liu Q, Huang W, Sun X, Wang X, Xu P, Zhao L, Xia T, Zhong W, Yang D, Eric Xu H, Zhang Y, Wang MW
Nat Commun (2021) 12 pp. 3763-3763 [ Pubmed: 34145245 DOI: doi:10.1038/s41467-021-24058-z ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Glucagon-like peptide 1 receptor (Complex from Homo sapiens)
- N-tert-butyl-6,7-bis(chloranyl)quinoxalin-2-amine (270 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein (Complex from Homo sapiens)
- Cryo-em structure of the compound 2-bound human glp-1 receptor-gs complex (Complex)
- Nanobody-35 (Complex from synthetic construct)
- Cholesterol (386 Da, Ligand)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
Cryo-EM structure of the compound 2-bound human GLP-1 receptor-Gs complex
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 7evm
Q-score: 0.481
Cong Z, Chen LN, Ma H, Zhou Q, Zou X, Ye C, Dai A, Liu Q, Huang W, Sun X, Wang X, Xu P, Zhao L, Xia T, Zhong W, Yang D, Eric Xu H, Zhang Y, Wang MW
Nat Commun (2021) 12 pp. 3763-3763 [ Pubmed: 34145245 DOI: doi:10.1038/s41467-021-24058-z ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Nanobody-35 (Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- N-tert-butyl-6,7-bis(chloranyl)quinoxalin-2-amine (270 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
- Cryo-em structure of the compound 2-bound human glp-1 receptor-gs complex (Complex)
- Guanine nucleotide-binding (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Glp-1 receptor (Complex from Homo sapiens)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
Cryo-EM structure of the compound 2 and GLP-1-bound human GLP-1 receptor-Gs complex
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 7duq
Q-score: 0.536
Cong Z, Chen LN, Ma H, Zhou Q, Zou X, Ye C, Dai A, Liu Q, Huang W, Sun X, Wang X, Xu P, Zhao L, Xia T, Zhong W, Yang D, Eric Xu H, Zhang Y, Wang MW
Nat Commun (2021) 12 pp. 3763-3763 [ Pubmed: 34145245 DOI: doi:10.1038/s41467-021-24058-z ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Glucagon-like peptide 1 receptor (Complex from Homo sapiens)
- Cryo-em structure of the compound 2 and glp-1-bound human glp-1 receptor-gs complex (Complex)
- Glucagon-like peptide 1 (3 kDa, Protein from Homo sapiens)
- Glucagon-like peptide 1 (Complex from Homo sapiens)
- N-tert-butyl-6,7-bis(chloranyl)quinoxalin-2-amine (270 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein (Complex from Homo sapiens)
- Nanobody-35 (Complex from synthetic construct)
- Cholesterol (386 Da, Ligand)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
GLP-1 peptide hormone bound to Glucagon-Like peptide-1 (GLP-1) Receptor
Resolution: 2.1 Å
EM Method: Single-particle
Fitted PDBs: 6x18
Q-score: 0.563
Zhang X, Belousoff MJ, Zhao P, Kooistra AJ, Truong TT, Ang SY, Underwood CR, Egebjerg T, Senel P, Stewart GD, Liang YL, Glukhova A, Venugopal H, Christopoulos A, Furness SGB, Miller LJ, Reedtz-Runge S, Langmead CJ, Gloriam DE, Danev R, Sexton PM, Wootten D
Mol Cell (2020) 80 pp. 485- [ Pubmed: 33027691 DOI: doi:10.1016/j.molcel.2020.09.020 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short, guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1, guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2, glucagon-like peptide 1 receptor (Complex from Homo sapiens)
- Nanobody 35 (Complex from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Nanobody35 (13 kDa, Protein from Lama glama)
- Glucagon-like peptide 1 receptor (56 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Glp-1 peptide hormone bound to glucagon-like peptide-1 (glp-1) receptor (120 kDa, Complex)
- Glucagon (3 kDa, Protein from Homo sapiens)