Consensus olfactory receptor consOR1 bound to L-menthol and in complex with mini-Gs trimeric protein
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8uxy
Q-score: 0.402
de March CA, Ma N, Billesbolle CB, Tewari J, Llinas Del Torrent C, van der Velden WJC, Ojiro I, Takayama I, Faust B, Li L, Vaidehi N, Manglik A, Matsunami H
Nature (2024) 635 pp. 499-508 [ DOI: doi:10.1038/s41586-024-08126-0 Pubmed: 39478229 ]
- Gnas complex locus (30 kDa, Protein from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Consor1 (35 kDa, Protein from synthetic construct)
- Consor51-minigs complex bound to nb35 (100 kDa, Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- (1r,2s,5r)-5-methyl-2-(propan-2-yl)cyclohexan-1-ol (156 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8uyq
Q-score: 0.262
de March CA, Ma N, Billesbolle CB, Tewari J, Llinas Del Torrent C, van der Velden WJC, Ojiro I, Takayama I, Faust B, Li L, Vaidehi N, Manglik A, Matsunami H
Nature (2024) 635 pp. 499-508 [ DOI: doi:10.1038/s41586-024-08126-0 Pubmed: 39478229 ]
- Gnas complex locus (30 kDa, Protein from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Consor4 (36 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Consor4-minigs complex bound to nb35 (100 kDa, Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- (2r)-2-methyl-1,3-thiazolidine (103 Da, Ligand)
ADP-bound purinergic receptor 1 in complex with miniGs/q
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8wjx
Q-score: 0.49
To Be Published
- Nanobody 35 (17 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Gnas complex locus (30 kDa, Protein from Homo sapiens)
- Adp-bound purinergic receptor 1 in complex with minigs/q (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,p2y purinoceptor 1,soluble cytochrome b562,p2y purinoceptor 1 (76 kDa, Protein from Homo sapiens)
MRE-269 bound Prostacyclin Receptor G protein complex
Resolution: 2.41 Å
EM Method: Single-particle
Fitted PDBs: 8x79
Q-score: 0.512
Wang JJ, Jin S, Zhang H, Xu Y, Hu W, Jiang Y, Chen C, Wang DW, Xu HE, Wu C
Sci Adv (2024) 10 pp. eadk5184-eadk5184 [ DOI: doi:10.1126/sciadv.adk5184 Pubmed: 38335293 ]
- Prostacyclin receptor (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short,gnas complex locus,gnas complex locus (29 kDa, Protein from Homo sapiens)
- Ip-gs complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- 2-[4-[(5,6-diphenylpyrazin-2-yl)-propan-2-yl-amino]butoxy]ethanoic acid (419 Da, Ligand)
- Nanobody35 (14 kDa, Protein from Homo sapiens)
Treprostinil bound Prostacyclin Receptor G protein complex
Resolution: 2.56 Å
EM Method: Single-particle
Fitted PDBs: 8x7a
Q-score: 0.439
Wang JJ, Jin S, Zhang H, Xu Y, Hu W, Jiang Y, Chen C, Wang DW, Xu HE, Wu C
Sci Adv (2024) 10 pp. eadk5184-eadk5184 [ DOI: doi:10.1126/sciadv.adk5184 Pubmed: 38335293 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short,gnas complex locus (29 kDa, Protein from Homo sapiens)
- Prostacyclin receptor (40 kDa, Protein from Homo sapiens)
- Ip-gs complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Treprostinil (390 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Nanobody35 (14 kDa, Protein from Homo sapiens)