Human Cx36/GJD2 gap junction channel with pore-lining N-terminal helices in porcine brain lipids.
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8xgd
Q-score: 0.568
Nat Commun (2024) 15 pp. 9223-9223 [ DOI: doi:10.1038/s41467-024-53587-6 Pubmed: 39455592 ]
- Cholesterol hemisuccinate (486 Da, Ligand)
- Gap junction delta-2 protein (37 kDa, Protein from Homo sapiens)
- Human cx36/gjd2 gap junction channel in brain lipids (Complex from Homo sapiens)
- 1,2-dimyristoyl-rac-glycero-3-phosphocholine (677 Da, Ligand)
Human Cx36/GJD2 gap junction channel in porcine brain lipids.
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 8xge
Q-score: 0.462
Nat Commun (2024) 15 pp. 9223-9223 [ DOI: doi:10.1038/s41467-024-53587-6 Pubmed: 39455592 ]
Human Cx36/GJD2 gap junction channel in complex with arachidonic acid.
Resolution: 2.95 Å
EM Method: Single-particle
Fitted PDBs: 8xgf
Q-score: 0.556
Nat Commun (2024) 15 pp. 9223-9223 [ DOI: doi:10.1038/s41467-024-53587-6 Pubmed: 39455592 ]
- Arachidonic acid (304 Da, Ligand)
- Human cx36/gjd2 gap junction channel (Complex from Homo sapiens)
- Gap junction delta-2 protein (37 kDa, Protein from Homo sapiens)
- 1,2-dimyristoyl-rac-glycero-3-phosphocholine (677 Da, Ligand)
Human Cx36/GJD2 gap junction channel in complex with mefloquine.
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8xgj
Q-score: 0.567
Nat Commun (2024) 15 pp. 9223-9223 [ DOI: doi:10.1038/s41467-024-53587-6 Pubmed: 39455592 ]
- Human cx36/gjd2 gap junction channel in complex with mefloquine (Cellular component from Homo sapiens)
- Gap junction delta-2 protein (37 kDa, Protein from Homo sapiens)
- 1,2-dimyristoyl-rac-glycero-3-phosphocholine (677 Da, Ligand)
- (11r,12s)- mefloquine (378 Da, Ligand)
Human Cx36/GJD2 (Ala14-deleted mutant) gap junction channel in porcine brain lipids
Resolution: 2.72 Å
EM Method: Single-particle
Fitted PDBs: 8xh8
Q-score: 0.582
Nat Commun (2024) 15 pp. 9223-9223 [ DOI: doi:10.1038/s41467-024-53587-6 Pubmed: 39455592 ]
- Human cx36/gjd2 gap junction channel (Complex from Homo sapiens)
- 1,2-dimyristoyl-rac-glycero-3-phosphocholine (677 Da, Ligand)
- Gap junction delta-2 protein (37 kDa, Protein from Homo sapiens)
Resolution: 2.58 Å
EM Method: Single-particle
Fitted PDBs: 8xh9
Q-score: 0.562
Nat Commun (2024) 15 pp. 9223-9223 [ DOI: doi:10.1038/s41467-024-53587-6 Pubmed: 39455592 ]
Cryo-EM structure of Cx26 from Gallus Gallus in bicarbonate buffer
Resolution: 2.07 Å
EM Method: Single-particle
Fitted PDBs: 8qvn
Q-score: 0.624
Nijjar S, Brotherton D, Butler J, Dospinescu VM, Gannon HG, Linthwaite V, Cann M, Cameron A, Dale N
J Physiol (2025) [ Pubmed: 39907096 DOI: doi:10.1113/JP285885 ]
- Water (18 Da, Ligand)
- Connexin 26 (gallus gallus) in 90mmhg pco2, ph7.4 (Complex from Gallus gallus)
- Phosphatidylethanolamine (734 Da, Ligand)
- Dodecyl-beta-d-maltoside (510 Da, Ligand)
- Gap junction protein (26 kDa, Protein from Gallus gallus)
human connexin36 gap junction channel in complex with quinidine
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 8r7r
Q-score: 0.587
To Be Published
- Quinidine (324 Da, Ligand)
- Gap junction delta-2 protein (37 kDa, Protein from Homo sapiens)
- Human connexin36 gap junction channel in complex with quinidine (Complex from Homo sapiens)
Connexin-32 gap junction channel in complex with 2-aminoethoxydiphenyl borate
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 8qjf
Q-score: 0.552
Lavriha P, Han Y, Ding X, Schuster D, Qi C, Vaithia A, Picotti P, Korkhov VM
PLoS One (2024) 19 pp. e0315510-e0315510 [ Pubmed: 39739741 DOI: doi:10.1371/journal.pone.0315510 ]
Connexin-32 gap junction channel in complex with mefloquine
Resolution: 2.91 Å
EM Method: Single-particle
Fitted PDBs: 8qjh
Q-score: 0.524
Lavriha P, Han Y, Ding X, Schuster D, Qi C, Vaithia A, Picotti P, Korkhov VM
PLoS One (2024) 19 pp. e0315510-e0315510 [ Pubmed: 39739741 DOI: doi:10.1371/journal.pone.0315510 ]