Focused refinement on Med1 within the human Mediator-bound transcription pre-initiation complex
Abdella R, Talyzina A, Chen S, Inouye CJ, Tjian R, He Y
Science (2021) 372 pp. 52-56 [ DOI: doi:10.1126/science.abg3074 Pubmed: 33707221 ]
- Mediator-bound pre-initiation complex (2 MDa, Complex)
- Rna polymerase ii (520 kDa, Complex from Homo sapiens)
- General transcription factors (300 kDa, Complex from Homo sapiens)
- Mediator (1 MDa, Complex from Homo sapiens)
- Promoter dna (Complex from Homo sapiens)
- Tfiih (500 kDa, Complex from Homo sapiens)
Human core-PIC in the closed state
Resolution: 5.4 Å
EM Method: Single-particle
Fitted PDBs: 5iya
Q-score: 0.169
He Y, Yan C, Fang J, Inouye C, Tjian R, Ivanov I, Nogales E
Nature (2016) 533 pp. 359-365 [ DOI: doi:10.1038/nature17970 Pubmed: 27193682 ]
- Dna-directed rna polymerase ii subunit rpb4 (16 kDa, Protein from Homo sapiens)
- General transcription factor iif subunit 1 (58 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase ii subunit rpb6 (14 kDa, Protein from Homo sapiens)
- Transcription initiation factor iib (34 kDa, Protein from Homo sapiens)
- Rna polymerase ii (520 kDa, Complex from Homo sapiens)
- General transcription factors (330 kDa, Complex from Homo sapiens)
- Dna-directed rna polymerase ii subunit rpb7 (19 kDa, Protein from Homo sapiens)
- Super core promoter (60 kDa, Complex from Homo sapiens)
- Dna-directed rna polymerase ii subunit rpb10 (7 kDa, Protein from Homo sapiens)
- Transcription elongation factor a protein 1 (34 kDa, Protein from Homo sapiens)
- General transcription factor iif subunit 2 (28 kDa, Protein from Homo sapiens)
- Scp-x (18 kDa, DNA from Homo sapiens)
- General transcription factor iie subunit 1 (49 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase ii subunit rpb5 (24 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase ii subunit rpb11-a (13 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase ii subunit rpb9 (14 kDa, Protein from Homo sapiens)
- Human holo-pic in the closed state (900 kDa, Complex from Homo sapiens)
- Dna-directed rna polymerase ii subunit rpb2 (134 kDa, Protein from Homo sapiens)
- Scp-y (18 kDa, DNA from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Transcription initiation factor iia subunit 2 (12 kDa, Protein from Homo sapiens)
- Transcription initiation factor iie subunit beta (33 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Transcription initiation factor iia subunit 1 (41 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase ii subunit rpb12 (7 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase ii subunit rpb3 (31 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase ii subunit rpb1 (217 kDa, Protein from Homo sapiens)
- Tata-box-binding protein (37 kDa, Protein from Homo sapiens)
- Dna-directed rna polymerase ii subunit rpb8 (17 kDa, Protein from Homo sapiens)