Gangwar SP, Yelshanskaya MV, Nadezhdin KD, Yen LY, Newton TP, Aktolun M, Kurnikova MG, Sobolevsky AI
Nature (2024) 630 pp. 762-768 [ Pubmed: 38778115 DOI: doi:10.1038/s41586-024-07475-0 ]
Gangwar SP, Yelshanskaya MV, Nadezhdin KD, Yen LY, Newton TP, Aktolun M, Kurnikova MG, Sobolevsky AI
Nature (2024) 630 pp. 762-768 [ Pubmed: 38778115 DOI: doi:10.1038/s41586-024-07475-0 ]
- Concanavalin a (Complex from Canavalia ensiformis)
- Glutamate receptor ionotropic, kainate 2 (Complex from Rattus norvegicus)
- Glutamate ionotropic receptor kainate type subunit 2 (Protein from Rattus norvegicus)
- Full-length rat gluk2 tetramer in complex with two concanavalin a dimers (510 kDa, Complex)
Gangwar SP, Yelshanskaya MV, Nadezhdin KD, Yen LY, Newton TP, Aktolun M, Kurnikova MG, Sobolevsky AI
Nature (2024) 630 pp. 762-768 [ Pubmed: 38778115 DOI: doi:10.1038/s41586-024-07475-0 ]
- Concanavalin a (Complex from Canavalia ensiformis)
- Glutamate receptor ionotropic, kainate 2 (Complex from Rattus norvegicus)
- Full-length rat gluk2 tetramer in complex with one concanavalin a homodimer (460 kDa, Complex)
- Glutamate ionotropic receptor kainate type subunit 2 (Protein from Rattus norvegicus)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 9b35
Q-score: 0.44
Gangwar SP, Yelshanskaya MV, Nadezhdin KD, Yen LY, Newton TP, Aktolun M, Kurnikova MG, Sobolevsky AI
Nature (2024) 630 pp. 762-768 [ Pubmed: 38778115 DOI: doi:10.1038/s41586-024-07475-0 ]
- Glutamic acid (147 Da, Ligand)
- Full-length rat gluk2 tetramer (410 kDa, Complex from Rattus norvegicus)
- Glutamate receptor ionotropic, kainate 2 (102 kDa, Protein from Rattus norvegicus)
Resolution: 4.29 Å
EM Method: Single-particle
Fitted PDBs: 9b36
Q-score: 0.402
Gangwar SP, Yelshanskaya MV, Nadezhdin KD, Yen LY, Newton TP, Aktolun M, Kurnikova MG, Sobolevsky AI
Nature (2024) 630 pp. 762-768 [ Pubmed: 38778115 DOI: doi:10.1038/s41586-024-07475-0 ]
- Full-length rat gluk2 tetramer in complex with two concanavalin a dimers (510 kDa, Complex from Rattus norvegicus)
- Concanavalin a (25 kDa, Protein from Canavalia ensiformis)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Glutamate receptor ionotropic, kainate 2 (102 kDa, Protein from Rattus norvegicus)
- Cholesterol (386 Da, Ligand)
- Glutamic acid (147 Da, Ligand)
- 4-cyclopropyl-7-fluoro-3,4-dihydro-2h-1,2,4-benzothiadiazine 1,1-dioxide (242 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Resolution: 6.66 Å
EM Method: Single-particle
Fitted PDBs: 9b37
Q-score: 0.369
Gangwar SP, Yelshanskaya MV, Nadezhdin KD, Yen LY, Newton TP, Aktolun M, Kurnikova MG, Sobolevsky AI
Nature (2024) 630 pp. 762-768 [ Pubmed: 38778115 DOI: doi:10.1038/s41586-024-07475-0 ]
- Concanavalin a (25 kDa, Protein from Canavalia ensiformis)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Glutamate receptor ionotropic, kainate 2 (102 kDa, Protein from Rattus norvegicus)
- Calcium ion (40 Da, Ligand)
- Full-length rat gluk2 tetramer in complex with one concanavalin a homodimer (460 kDa, Complex from Rattus norvegicus)
- Cholesterol (386 Da, Ligand)
- Glutamic acid (147 Da, Ligand)
- 4-cyclopropyl-7-fluoro-3,4-dihydro-2h-1,2,4-benzothiadiazine 1,1-dioxide (242 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
Resolution: 3.36 Å
EM Method: Single-particle
Fitted PDBs: 9b38
Q-score: 0.426
Gangwar SP, Yelshanskaya MV, Nadezhdin KD, Yen LY, Newton TP, Aktolun M, Kurnikova MG, Sobolevsky AI
Nature (2024) 630 pp. 762-768 [ Pubmed: 38778115 DOI: doi:10.1038/s41586-024-07475-0 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glutamate receptor ionotropic, kainate 2 (102 kDa, Protein from Rattus norvegicus)
- Full-length rat gluk2 tetramer (410 kDa, Complex from Rattus norvegicus)
- Glutamic acid (147 Da, Ligand)
- Alpha-d-mannopyranose (180 Da, Ligand)
Kainate receptor GluK2 in complex with agonist glutamate with asymmetric ligand-binding domain layer
Resolution: 3.84 Å
EM Method: Single-particle
Fitted PDBs: 9b39
Q-score: 0.339
Gangwar SP, Yelshanskaya MV, Nadezhdin KD, Yen LY, Newton TP, Aktolun M, Kurnikova MG, Sobolevsky AI
Nature (2024) 630 pp. 762-768 [ Pubmed: 38778115 DOI: doi:10.1038/s41586-024-07475-0 ]
- Glutamic acid (147 Da, Ligand)
- Full-length rat gluk2 tetramer (410 kDa, Complex from Rattus norvegicus)
- Glutamate receptor ionotropic, kainate 2 (102 kDa, Protein from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
cryo-EM structure of homomeric kainate receptor GluK2 in resting (apo) state
Resolution: 2.99 Å
EM Method: Single-particle
Fitted PDBs: 8f0o
Q-score: 0.361
To Be Published