Cryo-EM structure of the compound 2-bound human GLP-1 receptor-Gs complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7dur
Q-score: 0.273
Cong Z, Chen LN, Ma H, Zhou Q, Zou X, Ye C, Dai A, Liu Q, Huang W, Sun X, Wang X, Xu P, Zhao L, Xia T, Zhong W, Yang D, Eric Xu H, Zhang Y, Wang MW
Nat Commun (2021) 12 pp. 3763-3763 [ Pubmed: 34145245 DOI: doi:10.1038/s41467-021-24058-z ]
- Nanobody-35 (Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
- Cryo-em structure of the compound 2-bound human glp-1 receptor-gs complex (Complex)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- N-tert-butyl-6,7-bis(chloranyl)quinoxalin-2-amine (270 Da, Ligand)
- Guanine nucleotide-binding protein (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Glucagon-like peptide 1 receptor (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
Cryo-EM structure of the compound 2-bound human GLP-1 receptor-Gs complex
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 7evm
Q-score: 0.481
Cong Z, Chen LN, Ma H, Zhou Q, Zou X, Ye C, Dai A, Liu Q, Huang W, Sun X, Wang X, Xu P, Zhao L, Xia T, Zhong W, Yang D, Eric Xu H, Zhang Y, Wang MW
Nat Commun (2021) 12 pp. 3763-3763 [ Pubmed: 34145245 DOI: doi:10.1038/s41467-021-24058-z ]
- Nanobody-35 (Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
- Cryo-em structure of the compound 2-bound human glp-1 receptor-gs complex (Complex)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- N-tert-butyl-6,7-bis(chloranyl)quinoxalin-2-amine (270 Da, Ligand)
- Glp-1 receptor (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
Cryo-EM structure of the compound 2 and GLP-1-bound human GLP-1 receptor-Gs complex
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 7duq
Q-score: 0.536
Cong Z, Chen LN, Ma H, Zhou Q, Zou X, Ye C, Dai A, Liu Q, Huang W, Sun X, Wang X, Xu P, Zhao L, Xia T, Zhong W, Yang D, Eric Xu H, Zhang Y, Wang MW
Nat Commun (2021) 12 pp. 3763-3763 [ Pubmed: 34145245 DOI: doi:10.1038/s41467-021-24058-z ]
- Glucagon-like peptide 1 (Complex from Homo sapiens)
- Nanobody-35 (Complex from synthetic construct)
- Cryo-em structure of the compound 2 and glp-1-bound human glp-1 receptor-gs complex (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- N-tert-butyl-6,7-bis(chloranyl)quinoxalin-2-amine (270 Da, Ligand)
- Guanine nucleotide-binding protein (Complex from Homo sapiens)
- Glucagon-like peptide 1 (3 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Glucagon-like peptide 1 receptor (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
GLP-1R-Gs complex structure with a small molecule full agonist
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 7c2e
Q-score: 0.259
Ma H, Huang W, Wang X, Zhao L, Jiang Y, Liu F, Guo W, Sun X, Zhong W, Yuan D, Xu HE
Cell Res (2020) 30 pp. 1140-1142 [ Pubmed: 32724086 DOI: doi:10.1038/s41422-020-0384-8 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- 2-[[4-[6-[(4-cyano-2-fluoranyl-phenyl)methoxy]pyridin-2-yl]-3,6-dihydro-2~{h}-pyridin-1-yl]methyl]-3-[[(2~{s})-oxetan-2-yl]methyl]imidazo[4,5-b]pyridine-5-carboxylic acid (554 Da, Ligand)
- Nanobody 35|lama glama (15 kDa, Protein from Lama glama)
- Glp-1r-gs-nanobody (Complex from Homo sapiens)
- Glucagon-like peptide 1 receptor (56 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)