cryo-EM of human Glucagon-like peptide 1 receptor GLP-1R in apo form
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7rg9
Q-score: 0.476
Sun B, Willard FS, Feng D, Alsina-Fernandez J, Chen Q, Vieth M, Ho JD, Showalter AD, Stutsman C, Ding L, Suter TM, Dunbar JD, Carpenter JW, Mohammed FA, Aihara E, Brown RA, Bueno AB, Emmerson PJ, Moyers JS, Kobilka TS, Coghlan MP, Kobilka BK, Sloop KW
PNAS (2022) 119 pp. e2116506119-e2116506119 [ Pubmed: 35333651 DOI: doi:10.1073/pnas.2116506119 ]
- Single-chain variable fragment 16 (31 kDa, Protein from Mus musculus)
- Nanobody 35 (17 kDa, Protein from Lama glama)
- Glucagon-like peptide 1 receptor (51 kDa, Protein from Homo sapiens)
- Glucagon-like peptide 1 receptor in apo form (Complex from Homo sapiens)
- Isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short (43 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Trimeric stimulatory g protein (Complex from Homo sapiens)
- Cryo-em of apo form human glucagon-like peptide 1 receptor glp-1r, trimeric g protein complex and stabilizing antibodies (150 kDa, Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
cryo-EM of human Glucagon-like peptide 1 receptor GLP-1R bound to tirzepatide
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7rgp
Q-score: 0.484
Sun B, Willard FS, Feng D, Alsina-Fernandez J, Chen Q, Vieth M, Ho JD, Showalter AD, Stutsman C, Ding L, Suter TM, Dunbar JD, Carpenter JW, Mohammed FA, Aihara E, Brown RA, Bueno AB, Emmerson PJ, Moyers JS, Kobilka TS, Coghlan MP, Kobilka BK, Sloop KW
PNAS (2022) 119 pp. e2116506119-e2116506119 [ Pubmed: 35333651 DOI: doi:10.1073/pnas.2116506119 ]
- Single-chain variable fragment 16 (31 kDa, Protein from Mus musculus)
- Nanobody 35 (17 kDa, Protein from Lama glama)
- Glucagon-like peptide 1 receptor (51 kDa, Protein from Homo sapiens)
- Tirzepatide (4 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-3,isoform gnas-2 of guanine nucleotide-binding protein g(s) subunit alpha isoforms short (43 kDa, Protein from Homo sapiens)
- Glucagon-like peptide 1 receptor bound to tirzepatide (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Trimeric stimulatory g protein (Complex from Homo sapiens)
- Cryo-em of human glucagon-like peptide 1 receptor glp-1r bound to tirzepatide, trimeric g protein complex and stabilizing antibodies (150 kDa, Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)