Ex4-D-Ala bound to the glucagon-like peptide-1 receptor/g protein complex (conformer 1)
Resolution: 2.41 Å
EM Method: Single-particle
Fitted PDBs: 7s1m
Q-score: 0.581
Cary BP, Deganutti G, Zhao P, Truong TT, Piper SJ, Liu X, Belousoff MJ, Danev R, Sexton PM, Wootten D, Gellman SH
Nat Chem Biol (2022) 18 pp. 256-263 [ Pubmed: 34937906 DOI: doi:10.1038/s41589-021-00945-w ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Nb35 (13 kDa, Protein from Lama glama)
- Ex4-d-ala (4 kDa, Protein from synthetic construct)
- Glucagon-like peptide 1 receptor (56 kDa, Protein from Homo sapiens)
- Glp-1r bound to ex4-d-ala, g alpha s, g beta-1, g gamma-2, and nb35 (Complex from Homo sapiens)
Ex4-D-Ala bound to the glucagon-like peptide-1 receptor/g protein complex (conformer 2)
Resolution: 2.51 Å
EM Method: Single-particle
Fitted PDBs: 7s3i
Q-score: 0.58
Cary BP, Deganutti G, Zhao P, Truong TT, Piper SJ, Liu X, Belousoff MJ, Danev R, Sexton PM, Wootten D, Gellman SH
Nat Chem Biol (2022) 18 pp. 256-263 [ Pubmed: 34937906 DOI: doi:10.1038/s41589-021-00945-w ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Nb35 (13 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Glucagon-like peptide 1 receptor (56 kDa, Protein from Homo sapiens)
- Glp-1r bound to ex4-d-ala, g alpha s, g beta-1, g gamma-2, and nb35 (Complex from Homo sapiens)
Peptide-19 bound to the Glucagon-Like Peptide-1 Receptor (GLP-1R)
Resolution: 2.14 Å
EM Method: Single-particle
Fitted PDBs: 7rtb
Q-score: 0.533
Johnson RM, Zhang X, Piper SJ, Nettleton TJ, Vandekolk TH, Langmead CJ, Danev R, Sexton PM, Wootten D
Biochem Biophys Res Commun (2021) 578 pp. 84-90 [ Pubmed: 34547628 DOI: doi:10.1016/j.bbrc.2021.09.016 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Peptide-19-glp-1r-gs complex (Complex from Homo sapiens)
- Glucagon-like peptide 1 receptor (56 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Nb35 (13 kDa, Protein from Lama glama)
- Peptide-19 (4 kDa, Protein from synthetic construct)
- Water (18 Da, Ligand)