Structure of native tri-heteromeric GluN1-GluN2A-GluN2B NMDA receptor in rat cortex and hippocampus
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 8xlk
Q-score: 0.278
Zhang M, Feng J, Xie C, Song N, Jin C, Wang J, Zhao Q, Zhang L, Wang B, Sun Y, Guo F, Li Y, Zhu S
Cell (2025) [ Pubmed: 39855198 DOI: doi:10.1016/j.cell.2025.01.004 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Nmda receptor (Complex)
- Glutamate receptor ionotropic, nmda 2b (166 kDa, Protein from Rattus norvegicus)
- Heavy chain of glun2a fab, 28c (24 kDa, Protein from Mus musculoides)
- Native tri-heteromeric glun1-glun2a-glun2b nmda receptor in rat cortex and hippocampus (Tissue from Rattus norvegicus)
- Glutamate receptor ionotropic, nmda 1 (105 kDa, Protein from Rattus norvegicus)
- Light chain of glun2b fab2 (28 kDa, Protein from Mus musculoides)
- Fab 28c (Complex)
- Fab (Complex from Mus musculoides)
- Heavy chain of glun1 fab, 4f11 (15 kDa, Protein from Mus musculoides)
- Light chain of glun2a fab, 28c (22 kDa, Protein from Mus musculoides)
- (2r)-4-(3-phosphonopropyl)piperazine-2-carboxylic acid (252 Da, Ligand)
- Fab 4f11 (Complex)
- Glutamate receptor ionotropic, nmda 2a (165 kDa, Protein from Rattus norvegicus)
- Light chain of glun1 fab, 4f11 (13 kDa, Protein from Mus musculoides)
- Fab2 (Complex)
- Heavy chain of glun2b fab2 (26 kDa, Protein from Mus musculoides)
Structure of native di-heteromeric GluN1-GluN2B NMDA receptor in rat cortex and hippocampus
Resolution: 5.4 Å
EM Method: Single-particle
Fitted PDBs: 9jnn
Q-score: 0.183
Zhang M, Feng J, Xie C, Song N, Jin C, Wang J, Zhao Q, Zhang L, Wang B, Sun Y, Guo F, Li Y, Zhu S
Cell (2025) [ Pubmed: 39855198 DOI: doi:10.1016/j.cell.2025.01.004 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Light chain of glun2b fab2 (11 kDa, Protein from Mus musculus)
- Native di-heteromeric glun1-glun2b nmda receptor in rat cortex and hippocampus (Tissue)
- Glutamate receptor ionotropic, nmda 2b (91 kDa, Protein from Rattus norvegicus)
- Fab (Complex from Mus musculus)
- Glutamate receptor ionotropic, nmda 1 (91 kDa, Protein from Rattus norvegicus)
- Light chain of glun1 fab, 4f11 (11 kDa, Protein from Mus musculus)
- Heavy chain of glun2b fab2 (12 kDa, Protein from Mus musculus)
- (2r)-4-(3-phosphonopropyl)piperazine-2-carboxylic acid (252 Da, Ligand)
- Fab 4f11 (Complex)
- Nmda receptor (Complex from Rattus norvegicus)
- Heavy chain of glun1 fab, 4f11 (13 kDa, Protein from Mus musculus)
- Fab2 (Complex)
Human GluN1-2B with Fab 007-168
Resolution: 4.05 Å
EM Method: Single-particle
Fitted PDBs: 8vuu
Q-score: 0.316
Michalski K, Abdulla T, Kleeman S, Schmidl L, Gomez R, Simorowski N, Vallese F, Pruss H, Heckmann M, Geis C, Furukawa H
Nat Struct Mol Biol (2024) 31 pp. 1975-1986 [ DOI: doi:10.1038/s41594-024-01386-4 Pubmed: 39227719 ]
- 007-168 heavy (22 kDa, Protein from Homo sapiens)
- Glutamate receptor ionotropic, nmda 2b (91 kDa, Protein from Homo sapiens)
- Human glun1-2b with fab 007-168 (Complex from Homo sapiens)
- 007-168 light (23 kDa, Protein from Homo sapiens)
- Glutamate receptor ionotropic, nmda 1 (92 kDa, Protein from Homo sapiens)
Human GluN1-2B with Fab 007-168 Local refinement of ATD
Resolution: 3.69 Å
EM Method: Single-particle
Fitted PDBs: 8vuv
Q-score: 0.394
Michalski K, Abdulla T, Kleeman S, Schmidl L, Gomez R, Simorowski N, Vallese F, Pruss H, Heckmann M, Geis C, Furukawa H
Nat Struct Mol Biol (2024) 31 pp. 1975-1986 [ DOI: doi:10.1038/s41594-024-01386-4 Pubmed: 39227719 ]
- Glutamate receptor ionotropic, nmda 2b (40 kDa, Protein from Homo sapiens)
- 007-168 heavy (22 kDa, Protein from Homo sapiens)
- 007-168 light (23 kDa, Protein from Homo sapiens)
- Glutamate receptor ionotropic, nmda 1 (41 kDa, Protein from Homo sapiens)
- Human glun1-2b with fab 007-168 local refinement of atd (Complex from Homo sapiens)
Resolution: 3.81 Å
EM Method: Single-particle
Fitted PDBs: 8vuy
Q-score: 0.394
Michalski K, Abdulla T, Kleeman S, Schmidl L, Gomez R, Simorowski N, Vallese F, Pruss H, Heckmann M, Geis C, Furukawa H
Nat Struct Mol Biol (2024) 31 pp. 1975-1986 [ DOI: doi:10.1038/s41594-024-01386-4 Pubmed: 39227719 ]
- Glutamate receptor ionotropic, nmda 2b (91 kDa, Protein from Rattus norvegicus)
- Glutamate receptor ionotropic, nmda 1 (91 kDa, Protein from Rattus norvegicus)
- Rat glun1-2b with fab 003-102 (Complex from Homo sapiens)
- 003-102 light (11 kDa, Protein from Homo sapiens)
- 003-102 heavy (12 kDa, Protein from Homo sapiens)
rat GluN1a-2B Fab 003-102 local refinement
Resolution: 3.95 Å
EM Method: Single-particle
Fitted PDBs: 8vvh
Q-score: 0.442
Michalski K, Abdulla T, Kleeman S, Schmidl L, Gomez R, Simorowski N, Vallese F, Pruss H, Heckmann M, Geis C, Furukawa H
Nat Struct Mol Biol (2024) 31 pp. 1975-1986 [ DOI: doi:10.1038/s41594-024-01386-4 Pubmed: 39227719 ]
- Glutamate receptor ionotropic, nmda 1 (41 kDa, Protein from Rattus norvegicus)
- Rat glun1a-2b fab 003-102 local refinement (Complex from Homo sapiens)
- Glutamate receptor ionotropic, nmda 2b (40 kDa, Protein from Rattus norvegicus)
- 003-102 light (11 kDa, Protein from Homo sapiens)
- 003-102 heavy (12 kDa, Protein from Homo sapiens)
Resolution: 3.72 Å
EM Method: Single-particle
Fitted PDBs: 9are
Q-score: 0.362
Chou TH, Epstein M, Fritzemeier RG, Akins NS, Paladugu S, Ullman EZ, Liotta DC, Traynelis SF, Furukawa H
Nature (2024) 632 pp. 209-217 [ DOI: doi:10.1038/s41586-024-07742-0 Pubmed: 39085540 ]
- Glycine (75 Da, Ligand)
- Glutamate receptor ionotropic, nmda 2b (98 kDa, Protein from Rattus norvegicus)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Rattus norvegicus)
- Glutamic acid (147 Da, Ligand)
- Di-heterotetrameric glun1-glun2b nmda receptors (400 kDa, Complex from Rattus norvegicus)
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 9arf
Q-score: 0.473
Chou TH, Epstein M, Fritzemeier RG, Akins NS, Paladugu S, Ullman EZ, Liotta DC, Traynelis SF, Furukawa H
Nature (2024) 632 pp. 209-217 [ DOI: doi:10.1038/s41586-024-07742-0 Pubmed: 39085540 ]
- Glycine (75 Da, Ligand)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Rattus norvegicus)
- Rat glun1-glu2b di-heterotetrameric nmda receptor channel (400 kDa, Complex from Rattus norvegicus)
- Glutamate receptor ionotropic, nmda 2b (98 kDa, Protein from Rattus norvegicus)
- Glutamic acid (147 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Rat GluN1-GluN2B NMDA receptor channel in apo conformation
Resolution: 4.05 Å
EM Method: Single-particle
Fitted PDBs: 9arg
Q-score: 0.292
Chou TH, Epstein M, Fritzemeier RG, Akins NS, Paladugu S, Ullman EZ, Liotta DC, Traynelis SF, Furukawa H
Nature (2024) 632 pp. 209-217 [ DOI: doi:10.1038/s41586-024-07742-0 Pubmed: 39085540 ]
- Glutamate receptor ionotropic, nmda 2b (98 kDa, Protein from Rattus norvegicus)
- Di-heterotetrameric glun1-glun2b nmda receptors (400 kDa, Complex from Rattus norvegicus)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Rattus norvegicus)
Rat GluN1-GluN2B NMDA receptor channel in complex with glycine
Resolution: 3.69 Å
EM Method: Single-particle
Fitted PDBs: 9arh
Q-score: 0.419
Chou TH, Epstein M, Fritzemeier RG, Akins NS, Paladugu S, Ullman EZ, Liotta DC, Traynelis SF, Furukawa H
Nature (2024) 632 pp. 209-217 [ DOI: doi:10.1038/s41586-024-07742-0 Pubmed: 39085540 ]
- Glutamate receptor ionotropic, nmda 2b (98 kDa, Protein from Rattus norvegicus)
- Isoform b of glutamate receptor ionotropic, nmda 1 (108 kDa, Protein from Rattus norvegicus)
- Glycine (75 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Di-heterotetrameric glun1-glun2b nmda receptors (400 kDa, Complex from Rattus norvegicus)