Nonactive state of Gly-,Glu- bound GluN1a-2B-2D NMDAR
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 9d37
Q-score: 0.443
Kang H, Epstein M, Banke TG, Perszyk R, Simorowski N, Paladugu S, Liotta DC, Traynelis SF, Furukawa H
Neuron (2025) [ DOI: doi:10.1016/j.neuron.2025.01.013 ]
- Glutamic acid (147 Da, Ligand)
- Tri-heteromeric glun1-2b-2d nmdar (377 kDa, Complex from Homo sapiens)
- Glutamate receptor ionotropic, nmda 2d (94 kDa, Protein from Homo sapiens)
- Glutamate receptor ionotropic, nmda 1 (92 kDa, Protein from Homo sapiens)
- Glycine (75 Da, Ligand)
- Glutamate receptor ionotropic, nmda 2b (98 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Water (18 Da, Ligand)
Open state of Gly-,Glu-,EU1622-240 bound GluN1a-2B-2D NMDAR
Resolution: 3.95 Å
EM Method: Single-particle
Fitted PDBs: 9d38
Q-score: 0.323
Kang H, Epstein M, Banke TG, Perszyk R, Simorowski N, Paladugu S, Liotta DC, Traynelis SF, Furukawa H
Neuron (2025) [ DOI: doi:10.1016/j.neuron.2025.01.013 ]
- Glutamic acid (147 Da, Ligand)
- Tri-heteromeric glun1-2b-2d nmdar (377 kDa, Complex from Homo sapiens)
- Glutamate receptor ionotropic, nmda 2d (94 kDa, Protein from Homo sapiens)
- Glutamate receptor ionotropic, nmda 1 (92 kDa, Protein from Homo sapiens)
- Glycine (75 Da, Ligand)
- Glutamate receptor ionotropic, nmda 2b (98 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Gly-,PPDA- bound GluN1a-2B-2D NMDAR
Resolution: 3.65 Å
EM Method: Single-particle
Fitted PDBs: 9d39
Q-score: 0.385
Kang H, Epstein M, Banke TG, Perszyk R, Simorowski N, Paladugu S, Liotta DC, Traynelis SF, Furukawa H
Neuron (2025) [ DOI: doi:10.1016/j.neuron.2025.01.013 ]
- Glutamate receptor ionotropic, nmda 2d (94 kDa, Protein from Homo sapiens)
- Glutamate receptor ionotropic, nmda 1 (92 kDa, Protein from Homo sapiens)
- Glycine (75 Da, Ligand)
- Glutamate receptor ionotropic, nmda 2b (98 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (2s,3r)-1-(phenanthren-2-ylcarbonyl)piperazine-2,3-dicarboxylic acid (378 Da, Ligand)
- Tri-heteromeric glun1a-2b-2d nmdar (377 kDa, Complex from Homo sapiens)
Nonactive state of Gly-,Glu- bound GluN1a-2B-2D NMDAR (Low-res)
Resolution: 3.78 Å
EM Method: Single-particle
Fitted PDBs: 9d3a
Q-score: 0.368
Kang H, Epstein M, Banke TG, Perszyk R, Simorowski N, Paladugu S, Liotta DC, Traynelis SF, Furukawa H
Neuron (2025) [ DOI: doi:10.1016/j.neuron.2025.01.013 ]
- Glutamic acid (147 Da, Ligand)
- Tri-heteromeric glun1-2b-2d nmdar (377 kDa, Complex from Homo sapiens)
- Glutamate receptor ionotropic, nmda 2d (94 kDa, Protein from Homo sapiens)
- Glutamate receptor ionotropic, nmda 1 (92 kDa, Protein from Homo sapiens)
- Glycine (75 Da, Ligand)
- Glutamate receptor ionotropic, nmda 2b (98 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Gly-,Glu-,(S)-DQP-997-74 bound GluN1a-2B-2D NMDAR
Resolution: 3.71 Å
EM Method: Single-particle
Fitted PDBs: 9d3b
Q-score: 0.311
Kang H, Epstein M, Banke TG, Perszyk R, Simorowski N, Paladugu S, Liotta DC, Traynelis SF, Furukawa H
Neuron (2025) [ DOI: doi:10.1016/j.neuron.2025.01.013 ]
- Glutamic acid (147 Da, Ligand)
- Tri-heteromeric glun1-2b-2d nmdar (377 kDa, Complex from Homo sapiens)
- Glutamate receptor ionotropic, nmda 2d (94 kDa, Protein from Homo sapiens)
- 4-{(3r,5s)-5-(4-chlorophenyl)-3-[4-(4-chlorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]pyrazolidin-1-yl}-3,3-difluoro-4-oxobutanoic acid (572 Da, Ligand)
- Glutamate receptor ionotropic, nmda 1 (92 kDa, Protein from Homo sapiens)
- Glycine (75 Da, Ligand)
- Glutamate receptor ionotropic, nmda 2b (98 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Gly-,Glu-,(S)-(+)-ketamine bound GluN1a-2B-2D NMDAR
Resolution: 3.96 Å
EM Method: Single-particle
Fitted PDBs: 9d3c
Q-score: 0.353
Kang H, Epstein M, Banke TG, Perszyk R, Simorowski N, Paladugu S, Liotta DC, Traynelis SF, Furukawa H
Neuron (2025) [ DOI: doi:10.1016/j.neuron.2025.01.013 ]
- Glutamic acid (147 Da, Ligand)
- Tri-heteromeric glun1-2b-2d nmdar (377 kDa, Complex from Homo sapiens)
- Glutamate receptor ionotropic, nmda 2d (94 kDa, Protein from Homo sapiens)
- Glutamate receptor ionotropic, nmda 1 (92 kDa, Protein from Homo sapiens)
- (2~{s})-2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one (237 Da, Ligand)
- Glycine (75 Da, Ligand)
- Glutamate receptor ionotropic, nmda 2b (98 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.72 Å
EM Method: Single-particle
Fitted PDBs: 9are
Q-score: 0.362
Chou TH, Epstein M, Fritzemeier RG, Akins NS, Paladugu S, Ullman EZ, Liotta DC, Traynelis SF, Furukawa H
Nature (2024) 632 pp. 209-217 [ Pubmed: 39085540 DOI: doi:10.1038/s41586-024-07742-0 ]
- Di-heterotetrameric glun1-glun2b nmda receptors (400 kDa, Complex from Rattus norvegicus)
- Glutamate receptor ionotropic, nmda 2b (98 kDa, Protein from Rattus norvegicus)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Rattus norvegicus)
- Glutamic acid (147 Da, Ligand)
- Glycine (75 Da, Ligand)
Resolution: 3.13 Å
EM Method: Single-particle
Fitted PDBs: 9arf
Q-score: 0.473
Chou TH, Epstein M, Fritzemeier RG, Akins NS, Paladugu S, Ullman EZ, Liotta DC, Traynelis SF, Furukawa H
Nature (2024) 632 pp. 209-217 [ Pubmed: 39085540 DOI: doi:10.1038/s41586-024-07742-0 ]
- Glutamate receptor ionotropic, nmda 2b (98 kDa, Protein from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Rat glun1-glu2b di-heterotetrameric nmda receptor channel (400 kDa, Complex from Rattus norvegicus)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Rattus norvegicus)
- Glutamic acid (147 Da, Ligand)
- Glycine (75 Da, Ligand)
Rat GluN1-GluN2B NMDA receptor channel in apo conformation
Resolution: 4.05 Å
EM Method: Single-particle
Fitted PDBs: 9arg
Q-score: 0.292
Chou TH, Epstein M, Fritzemeier RG, Akins NS, Paladugu S, Ullman EZ, Liotta DC, Traynelis SF, Furukawa H
Nature (2024) 632 pp. 209-217 [ Pubmed: 39085540 DOI: doi:10.1038/s41586-024-07742-0 ]
- Glutamate receptor ionotropic, nmda 2b (98 kDa, Protein from Rattus norvegicus)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Rattus norvegicus)
- Di-heterotetrameric glun1-glun2b nmda receptors (400 kDa, Complex from Rattus norvegicus)
Rat GluN1-GluN2B NMDA receptor channel in complex with glycine
Resolution: 3.69 Å
EM Method: Single-particle
Fitted PDBs: 9arh
Q-score: 0.419
Chou TH, Epstein M, Fritzemeier RG, Akins NS, Paladugu S, Ullman EZ, Liotta DC, Traynelis SF, Furukawa H
Nature (2024) 632 pp. 209-217 [ Pubmed: 39085540 DOI: doi:10.1038/s41586-024-07742-0 ]
- Di-heterotetrameric glun1-glun2b nmda receptors (400 kDa, Complex from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glutamate receptor ionotropic, nmda 2b (98 kDa, Protein from Rattus norvegicus)
- Isoform b of glutamate receptor ionotropic, nmda 1 (108 kDa, Protein from Rattus norvegicus)
- Glycine (75 Da, Ligand)