Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 7saa
Q-score: 0.505
Chou TH, Epstein M, Michalski K, Fine E, Biggin PC, Furukawa H
Nat Struct Mol Biol (2022) 29 pp. 507-518 [ Pubmed: 35637422 DOI: doi:10.1038/s41594-022-00772-0 ]
- Glutamate receptor ionotropic, nmda 2b (98 kDa, Protein from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Rattus norvegicus)
- Glutamic acid (147 Da, Ligand)
- Glycine (75 Da, Ligand)
- Hetero-tetrameric glun1a-glun2b nmda receptors (Complex from Rattus norvegicus)
S-(+)-ketamine bound GluN1a-GluN2B NMDA receptors at 3.69 Angstrom resolution
Resolution: 3.69 Å
EM Method: Single-particle
Fitted PDBs: 7sac
Q-score: 0.419
Chou TH, Epstein M, Michalski K, Fine E, Biggin PC, Furukawa H
Nat Struct Mol Biol (2022) 29 pp. 507-518 [ Pubmed: 35637422 DOI: doi:10.1038/s41594-022-00772-0 ]
- Glutamate receptor ionotropic, nmda 2b (98 kDa, Protein from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (2~{s})-2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one (237 Da, Ligand)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Rattus norvegicus)
- Glutamic acid (147 Da, Ligand)
- Glycine (75 Da, Ligand)
- Hetero-tetrameric glun1a-glun2b nmda receptors (Complex from Rattus norvegicus)
Memantine-bound GluN1a-GluN2B NMDA receptors
Resolution: 3.96 Å
EM Method: Single-particle
Fitted PDBs: 7sad
Q-score: 0.376
Chou TH, Epstein M, Michalski K, Fine E, Biggin PC, Furukawa H
Nat Struct Mol Biol (2022) 29 pp. 507-518 [ Pubmed: 35637422 DOI: doi:10.1038/s41594-022-00772-0 ]
- Glutamate receptor ionotropic, nmda 2b (98 kDa, Protein from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Rattus norvegicus)
- Memantine (179 Da, Ligand)
- Hetero-tetrameric glun1a-glun2b nmda receptors (Complex from Rattus norvegicus)
GluN1b-GluN2B NMDA receptor in non-active 2 conformation at 4 angstrom resolution
Resolution: 3.99 Å
EM Method: Single-particle
Fitted PDBs: 6whr
Q-score: 0.411
Chou TH, Tajima N, Romero-Hernandez A, Furukawa H
Cell (2020) 182 pp. 357-371.e13 [ DOI: doi:10.1016/j.cell.2020.05.052 Pubmed: 32610085 ]
- Glutamate receptor ionotropic, nmda 2b (98 kDa, Protein from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glutamate receptor ionotropic, nmda 1 (108 kDa, Protein from Rattus norvegicus)
- Nmda receptor glun1b/2b functional ion channel complex (Complex from Rattus norvegicus)
GluN1b-GluN2B NMDA receptor in non-active 1 conformation at 3.95 angstrom resolution
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 6whs
Q-score: 0.421
Chou TH, Tajima N, Romero-Hernandez A, Furukawa H
Cell (2020) 182 pp. 357-371.e13 [ DOI: doi:10.1016/j.cell.2020.05.052 Pubmed: 32610085 ]
- Glutamate receptor ionotropic, nmda 2b (98 kDa, Protein from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glutamate receptor ionotropic, nmda 1 (108 kDa, Protein from Rattus norvegicus)
- Nmda receptor glun1b/2b functional ion channel complex (Complex from Rattus norvegicus)
GluN1b-GluN2B NMDA receptor in active conformation at 4.4 angstrom resolution
Resolution: 4.39 Å
EM Method: Single-particle
Fitted PDBs: 6wht
Q-score: 0.35
Chou TH, Tajima N, Romero-Hernandez A, Furukawa H
Cell (2020) 182 pp. 357-371.e13 [ DOI: doi:10.1016/j.cell.2020.05.052 Pubmed: 32610085 ]
- Glutamate receptor ionotropic, nmda 2b (98 kDa, Protein from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glutamate receptor ionotropic, nmda 1 (108 kDa, Protein from Rattus norvegicus)
- Nmda receptor glun1b/2b functional ion channel complex (Complex from Rattus norvegicus)
GluN1b-GluN2B NMDA receptor in complex with SDZ 220-040 and L689,560, class 1
Resolution: 3.93 Å
EM Method: Single-particle
Fitted PDBs: 6whu
Q-score: 0.42
Chou TH, Tajima N, Romero-Hernandez A, Furukawa H
Cell (2020) 182 pp. 357-371.e13 [ DOI: doi:10.1016/j.cell.2020.05.052 Pubmed: 32610085 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (2s)-2-amino-3-[2',4'-dichloro-4-hydroxy-5-(phosphonomethyl)biphenyl-3-yl]propanoic acid (420 Da, Ligand)
- (2r,4s)-5,7-dichloro-4-[(phenylcarbamoyl)amino]-1,2,3,4-tetrahydroquinoline-2-carboxylic acid (380 Da, Ligand)
- Glutamate receptor ionotropic, nmda 1 (108 kDa, Protein from Rattus norvegicus)
- Glutamate receptor ionotropic, nmda 2b (98 kDa, Protein from Rattus norvegicus)
- Nmda receptor glun1b/2b functional ion channel complex (Complex from Rattus norvegicus)
GluN1b-GluN2B NMDA receptor in complex with SDZ 220-040 and L689,560, class 2
Resolution: 4.05 Å
EM Method: Single-particle
Fitted PDBs: 6whv
Q-score: 0.394
Chou TH, Tajima N, Romero-Hernandez A, Furukawa H
Cell (2020) 182 pp. 357-371.e13 [ DOI: doi:10.1016/j.cell.2020.05.052 Pubmed: 32610085 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (2s)-2-amino-3-[2',4'-dichloro-4-hydroxy-5-(phosphonomethyl)biphenyl-3-yl]propanoic acid (420 Da, Ligand)
- (2r,4s)-5,7-dichloro-4-[(phenylcarbamoyl)amino]-1,2,3,4-tetrahydroquinoline-2-carboxylic acid (380 Da, Ligand)
- Glutamate receptor ionotropic, nmda 1 (108 kDa, Protein from Rattus norvegicus)
- Glutamate receptor ionotropic, nmda 2b (98 kDa, Protein from Rattus norvegicus)
- Nmda receptor glun1b/2b functional ion channel complex (Complex from Rattus norvegicus)
GluN1b-GluN2B NMDA receptor in complex with GluN1 antagonist L689,560, class 2
Resolution: 4.27 Å
EM Method: Single-particle
Fitted PDBs: 6wi0
Q-score: 0.357
Chou TH, Tajima N, Romero-Hernandez A, Furukawa H
Cell (2020) 182 pp. 357-371.e13 [ DOI: doi:10.1016/j.cell.2020.05.052 Pubmed: 32610085 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (2r,4s)-5,7-dichloro-4-[(phenylcarbamoyl)amino]-1,2,3,4-tetrahydroquinoline-2-carboxylic acid (380 Da, Ligand)
- Glutamate receptor ionotropic, nmda 1 (108 kDa, Protein from Rattus norvegicus)
- Glutamate receptor ionotropic, nmda 2b (98 kDa, Protein from Rattus norvegicus)
- Nmda receptor glun1b/2b functional ion channel complex (Complex from Rattus norvegicus)