de March CA, Ma N, Billesbolle CB, Tewari J, Llinas Del Torrent C, van der Velden WJC, Ojiro I, Takayama I, Faust B, Li L, Vaidehi N, Manglik A, Matsunami H
Nature (2024) 635 pp. 499-508 [ DOI: doi:10.1038/s41586-024-08126-0 Pubmed: 39478229 ]
- Consor1-minigs complex bound to nb35 (100 kDa, Complex from synthetic construct)
de March CA, Ma N, Billesbolle CB, Tewari J, Llinas Del Torrent C, van der Velden WJC, Ojiro I, Takayama I, Faust B, Li L, Vaidehi N, Manglik A, Matsunami H
Nature (2024) 635 pp. 499-508 [ DOI: doi:10.1038/s41586-024-08126-0 Pubmed: 39478229 ]
- Consor2-minigs complex bound to nb35 (100 kDa, Complex from synthetic construct)
de March CA, Ma N, Billesbolle CB, Tewari J, Llinas Del Torrent C, van der Velden WJC, Ojiro I, Takayama I, Faust B, Li L, Vaidehi N, Manglik A, Matsunami H
Nature (2024) 635 pp. 499-508 [ DOI: doi:10.1038/s41586-024-08126-0 Pubmed: 39478229 ]
- Consor51-minigs complex bound to nb35 (100 kDa, Complex from synthetic construct)
Consensus olfactory receptor consOR51 in complex with
de March CA, Ma N, Billesboelle CB, Tewari J, del Torrent CL, van der Velden WJC, Faust B, Vaidehi N, Manglik A, Matsunami H
To Be Published
- Consor51-minigs complex bound to nb35 (100 kDa, Complex from synthetic construct)
- Consor51 (Macromolecule from synthetic construct)
de March CA, Ma N, Billesbolle CB, Tewari J, Llinas Del Torrent C, van der Velden WJC, Ojiro I, Takayama I, Faust B, Li L, Vaidehi N, Manglik A, Matsunami H
Nature (2024) 635 pp. 499-508 [ DOI: doi:10.1038/s41586-024-08126-0 Pubmed: 39478229 ]
- Consor4-minigs complex bound to nb35 (100 kDa, Complex from synthetic construct)
Consensus olfactory receptor consOR51 in complex with mini-Gs trimeric protein
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8uxv
Q-score: 0.544
de March CA, Ma N, Billesbolle CB, Tewari J, Llinas Del Torrent C, van der Velden WJC, Ojiro I, Takayama I, Faust B, Li L, Vaidehi N, Manglik A, Matsunami H
Nature (2024) 635 pp. 499-508 [ DOI: doi:10.1038/s41586-024-08126-0 Pubmed: 39478229 ]
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Consor51 (36 kDa, Protein from synthetic construct)
- Minigs399 (30 kDa, Protein from Homo sapiens)
- Consor51-minigs complex bound to nb35 (100 kDa, Complex from synthetic construct)
Consensus olfactory receptor consOR1 bound to L-menthol and in complex with mini-Gs trimeric protein
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8uxy
Q-score: 0.402
de March CA, Ma N, Billesbolle CB, Tewari J, Llinas Del Torrent C, van der Velden WJC, Ojiro I, Takayama I, Faust B, Li L, Vaidehi N, Manglik A, Matsunami H
Nature (2024) 635 pp. 499-508 [ DOI: doi:10.1038/s41586-024-08126-0 Pubmed: 39478229 ]
- Nanobody 35 (15 kDa, Protein from Lama glama)
- (1r,2s,5r)-5-methyl-2-(propan-2-yl)cyclohexan-1-ol (156 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Consor1 (35 kDa, Protein from synthetic construct)
- Gnas complex locus (30 kDa, Protein from Homo sapiens)
- Consor51-minigs complex bound to nb35 (100 kDa, Complex from synthetic construct)
Consensus olfactory receptor consOR2 bound to S-carvone and in complex with mini-Gs trimeric protein
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8uy0
Q-score: 0.489
de March CA, Ma N, Billesbolle CB, Tewari J, Llinas Del Torrent C, van der Velden WJC, Ojiro I, Takayama I, Faust B, Li L, Vaidehi N, Manglik A, Matsunami H
Nature (2024) 635 pp. 499-508 [ DOI: doi:10.1038/s41586-024-08126-0 Pubmed: 39478229 ]
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Consor2-minigs complex bound to nb35 (100 kDa, Complex from synthetic construct)
- Consor2 (35 kDa, Protein from synthetic construct)
- Minigs399 (30 kDa, Protein from Homo sapiens)
- (5s)-2-methyl-5-(prop-1-en-2-yl)cyclohex-2-en-1-one (150 Da, Ligand)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8uyq
Q-score: 0.262
de March CA, Ma N, Billesbolle CB, Tewari J, Llinas Del Torrent C, van der Velden WJC, Ojiro I, Takayama I, Faust B, Li L, Vaidehi N, Manglik A, Matsunami H
Nature (2024) 635 pp. 499-508 [ DOI: doi:10.1038/s41586-024-08126-0 Pubmed: 39478229 ]
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Consor4-minigs complex bound to nb35 (100 kDa, Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- (2r)-2-methyl-1,3-thiazolidine (103 Da, Ligand)
- Consor4 (36 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gnas complex locus (30 kDa, Protein from Homo sapiens)
Propionate bound to human olfactory receptor OR51E2 in complex with miniGs399 (transmembrane domain)
Billesbolle CB, de March CA, van der Velden WJC, Ma N, Tewari J, Del Torrent CL, Li L, Faust B, Vaidehi N, Matsunami H, Manglik A
Nature (2023) 615 pp. 742-749 [ DOI: doi:10.1038/s41586-023-05798-y Pubmed: 36922591 ]
- Or51e2-gs complex (100 kDa, Complex from Homo sapiens)