Cryo-EM structure of the retatrutide-bound human GLP-1R-Gs complex
Resolution: 2.68 Å
EM Method: Single-particle
Fitted PDBs: 8yw3
Q-score: 0.514
Li W, Zhou Q, Cong Z, Yuan Q, Li W, Zhao F, Xu HE, Zhao LH, Yang D, Wang MW
Cell Discov (2024) 10 pp. 77-77 [ Pubmed: 39019866 DOI: doi:10.1038/s41421-024-00700-0 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Retatrutide (3 kDa, Protein from Homo sapiens)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Cryo-em structure of the human glucagon-like peptide-1 receptor in complex with retatrutide and g protein (Complex from Homo sapiens)
Cryo-EM structure of peptide free and Gs-coupled GIPR
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 8wa3
Q-score: 0.464
Cong Z, Zhao F, Li Y, Luo G, Mai Y, Chen X, Chen Y, Lin S, Cai X, Zhou Q, Yang D, Wang MW
Cell Discov (2024) 10 pp. 18-18 [ Pubmed: 38346960 DOI: doi:10.1038/s41421-024-00649-0 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Bos taurus)
- Gastric inhibitory polypeptide receptor,fusion protein (64 kDa, Protein from Homo sapiens)
- Cryo-em structure of the human glucose-dependent insulinotropic polypeptide receptor in complex with gip and g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,o-antigen polymerase (40 kDa, Protein from Leptolinea tardivitalis)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
Cryo-EM structures of peptide free and Gs-coupled GLP-1R
Resolution: 2.54 Å
EM Method: Single-particle
Fitted PDBs: 8wg7
Q-score: 0.513
Cong Z, Zhao F, Li Y, Luo G, Mai Y, Chen X, Chen Y, Lin S, Cai X, Zhou Q, Yang D, Wang MW
Cell Discov (2024) 10 pp. 18-18 [ Pubmed: 38346960 DOI: doi:10.1038/s41421-024-00649-0 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Rattus norvegicus)
- Cryo-em structure of the human glucagon like peptide 1 receptor in complex with tirzepatide and g protein (Complex from Homo sapiens)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Nanobody-35 (13 kDa, Protein from synthetic construct)
Cryo-EM structures of peptide free and Gs-coupled GCGR
Resolution: 2.71 Å
EM Method: Single-particle
Fitted PDBs: 8wg8
Q-score: 0.498
Cong Z, Zhao F, Li Y, Luo G, Mai Y, Chen X, Chen Y, Lin S, Cai X, Zhou Q, Yang D, Wang MW
Cell Discov (2024) 10 pp. 18-18 [ Pubmed: 38346960 DOI: doi:10.1038/s41421-024-00649-0 ]
- Pro-pro-pro-pro-phe-ser-asn-leu-val-met-asp-asp-leu-lys-asn-lys-lys (1 kDa, Protein from Spodoptera frugiperda)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Rattus norvegicus)
- Cryo-em structure of the human glucagon like peptide 1 receptor in complex with tirzepatide and g protein (Complex from Homo sapiens)
- Glucagon receptor (46 kDa, Protein from Homo sapiens)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (41 kDa, Protein from Homo sapiens)
Cryo-EM structure of the alpha-MSH-bound human melanocortin receptor 5 (MC5R)-Gs complex
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 8inr
Q-score: 0.49
Feng W, Zhou Q, Chen X, Dai A, Cai X, Liu X, Zhao F, Chen Y, Ye C, Xu Y, Cong Z, Li H, Lin S, Yang D, Wang MW
Cell Discov (2023) 9 pp. 81- [ DOI: doi:10.1107/S0907444909042073 Pubmed: 37524700 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,hibit (40 kDa, Protein from Homo sapiens)
- Alpha-melanocyte-stimulating hormone (1 kDa, Protein from synthetic construct)
- Cryo-em structure of alpha-msh-bound human melanocortin receptor 5 in complex with g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Ha signal peptide,melanocortin receptor 5,lgbit subunit (56 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short (41 kDa, Protein from Homo sapiens)
Cryo-EM structure of the gamma-MSH-bound human melanocortin receptor 3 (MC3R)-Gs complex
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 8ioc
Q-score: 0.459
Feng W, Zhou Q, Chen X, Dai A, Cai X, Liu X, Zhao F, Chen Y, Ye C, Xu Y, Cong Z, Li H, Lin S, Yang D, Wang MW
Cell Discov (2023) 9 pp. 81- [ DOI: doi:10.1107/S0907444909042073 Pubmed: 37524700 ]
- Ha signal peptide,melanocortin receptor 3,lgbit subunit (56 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,hibit (40 kDa, Protein from Homo sapiens)
- Gamma-melanocyte-stimulating hormone (1 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Cryo-em structure of gamma-msh-bound human melanocortin receptor 3 in complex with g protein (Complex from Homo sapiens)
- Nanobody-35 (17 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short (41 kDa, Protein from Homo sapiens)
Cryo-EM structure of the PG-901-bound human melanocortin receptor 5 (MC5R)-Gs complex
Resolution: 2.59 Å
EM Method: Single-particle
Fitted PDBs: 8iod
Q-score: 0.503
Feng W, Zhou Q, Chen X, Dai A, Cai X, Liu X, Zhao F, Chen Y, Ye C, Xu Y, Cong Z, Li H, Lin S, Yang D, Wang MW
Cell Discov (2023) 9 pp. 81- [ DOI: doi:10.1107/S0907444909042073 Pubmed: 37524700 ]
- Cryo-em structure of pg-901-bound human melanocortin receptor 5 in complex with g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,hibit (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Pg-901 (1 kDa, Protein from synthetic construct)
- Nanobody-35 (17 kDa, Protein from Homo sapiens)
- Ha signal peptide,melanocortin receptor 5,lgbit subunit (56 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short (41 kDa, Protein from Homo sapiens)
Human vasoactive intestinal polypeptide receptor 2 (VIP2R) in complex with PACAP27 and Gs
Resolution: 2.74 Å
EM Method: Single-particle
Fitted PDBs: 7vqx
Q-score: 0.543
Xu Y, Feng W, Zhou Q, Liang A, Li J, Dai A, Zhao F, Yan J, Chen CW, Li H, Zhao LH, Xia T, Jiang Y, Xu HE, Yang D, Wang MW
Nat Commun (2022) 13 pp. 2272-2272 [ Pubmed: 35477937 DOI: doi:10.1038/s41467-022-30041-z ]
- Cryo-em structure of the human vasoactive intestinal polypeptide receptor 2 in commplex with pacap27 and g protein (Complex from Bos taurus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Bos taurus)
- Human vasoactive intestinal polypeptide receptor 2 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (Complex)
- Guanine nucleotide-binding protein g(i) /g(s) /g(o) subunit gamma-2 (Complex from Homo sapiens)
- Nanobody-35 (Complex)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
- Vasoactive intestinal polypeptide receptor 2 (64 kDa, Protein from Homo sapiens)
- Pituitary adenylate cyclase activating peptide-27 (Complex from Bos taurus)
- Pituitary adenylate cyclase-activating polypeptide 27 (3 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) /g(s) /g(t) subunit beta-1 (Complex from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (43 kDa, Protein from Rattus norvegicus)
Resolution: 3.42 Å
EM Method: Single-particle
Fitted PDBs: 7wbj
Q-score: 0.425
Xu Y, Feng W, Zhou Q, Liang A, Li J, Dai A, Zhao F, Yan J, Chen CW, Li H, Zhao LH, Xia T, Jiang Y, Xu HE, Yang D, Wang MW
Nat Commun (2022) 13 pp. 2272-2272 [ Pubmed: 35477937 DOI: doi:10.1038/s41467-022-30041-z ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Bos taurus)
- Vasoactive intestinal polypeptide receptor 2 (49 kDa, Protein from Homo sapiens)
- Cryo-em structure of the human vasoactive intestinal polypeptide receptor 2 in commplex with pacap27 and g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Nanobody-35 (Complex)
- Vasoactive intestinal polypeptide receptor 2 (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from synthetic construct)
- Pituitary adenylate cyclase-activating polypeptide 27 (Complex from Bos taurus)
- Nanobody-35 (15 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short/g(i)/g(s)/g(o) subunit gamma-2 (Complex from Rattus norvegicus)
- Pituitary adenylate cyclase-activating polypeptide 27 (3 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (43 kDa, Protein from Rattus norvegicus)
Cryo-EM structure of the GIPR/GLP-1R/GCGR triagonist peptide 20-bound human GLP-1R-Gs complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7vbh
Q-score: 0.397
Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW
Nat Commun (2022) 13 pp. 1057-1057 [ DOI: doi:10.1038/s41467-022-28683-0 Pubmed: 35217653 ]
- Cryo-em structure of the human glucagon-like peptide-1 receptor in complex with peptide 20 and g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Peptide 20 (4 kDa, Protein from Homo sapiens)
- N-hexadecanoyl-l-glutamic acid (385 Da, Ligand)
- Cryo-em structure of the peptide 20-bound human glucagon-like peptide-1 receptor in complex with gs protein (Complex from Homo sapiens)
- Glucagon-like peptide 1 receptor (50 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Escherichia coli)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)