T1AM-bound mTAAR1-Gs protein complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8jlj
Q-score: 0.543
Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z
Nature (2023) 624 pp. 672-681 [ DOI: doi:10.1038/s41586-023-06804-z Pubmed: 37935376 ]
- Gs heterotrimer (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- T1am-bound htaar1 (Complex from Mus musculus)
- Htaar1-bound t1am in complex with gs heterotrimer (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- 4-[4-(2-azanylethyl)-2-iodanyl-phenoxy]phenol (355 Da, Ligand)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Scfv16 (Complex from Mus musculus)
- Mgs (41 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,trace amine-associated receptor 1 (50 kDa, Protein from Mus musculus)
T1AM-bound hTAAR1-Gs protein complex
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 8jln
Q-score: 0.427
Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z
Nature (2023) 624 pp. 672-681 [ DOI: doi:10.1038/s41586-023-06804-z Pubmed: 37935376 ]
- Gs heterotrimer (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,trace amine-associated receptor 1 (54 kDa, Protein from Homo sapiens)
- Htaar1-bound t1am in complex with gs heterotrimer (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- T1am-bound htaar1 (Complex from Homo sapiens)
- 4-[4-(2-azanylethyl)-2-iodanyl-phenoxy]phenol (355 Da, Ligand)
- Scfv16 (Complex from Mus musculus)
- Mgs (43 kDa, Protein from Homo sapiens)
AMPH-bound hTAAR1-Gs protein complex
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8jso
Q-score: 0.439
Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z
Nature (2023) 624 pp. 672-681 [ DOI: doi:10.1038/s41586-023-06804-z Pubmed: 37935376 ]
- Amphetamine-bound htaar1 (Complex from Homo sapiens)
- Gs heterotrimer (Complex from Homo sapiens)
- Soluble cytochrome b562,trace amine-associated receptor 1 (54 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Mus musculus)
- Scfv16 (26 kDa, Protein from Mus musculus)
- (2s)-1-phenylpropan-2-amine (135 Da, Ligand)
- Scfv16 (Complex from Mus musculus)
- Mgs (41 kDa, Protein from Homo sapiens)
- Htaar1-bound amphetamine in complex with gs heterotrimer (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)